Cystathionine γ-Lyase Identified as a Key Regulator of Memory and Learning
January 1, 2026
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Brand Name :
Mesantoin
Synonyms :
mephenytoin
Class :
Hydantoin derivatives, Imiazolidinedione
Brand Name :
Mesantoin
Synonyms :
mephenytoin
Class :
Hydantoin derivatives, Imiazolidinedione
Dosage Forms & Strengths
Tablet
100 mg
Not determined
Refer to adult dosing
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
Combining mephenytoin with pranlukast may cause a reduction in the mephenytoin’s metabolism
The potential for increased CNS depression risk or seriousness occurs when mephenytoin is used together with pinazepam
When dexrabeprazole and mephenytoin is used together, this leads to reduction in the dexrabeprazole’s metabolism
When mephenytoin is used together with somatotropin, this leads to a rise in mephenytoin metabolism
When encainide is used together with mephenytoin, this leads to a reduction in the encainide’s metabolism
may have an increasingly adverse effect when combined with sodium phosphates
may have an increasingly adverse effect when combined with sodium phosphates
may have an increasingly adverse effect when combined with sodium phosphates
may have an increasingly adverse effect when combined with sodium phosphates
may have an increasingly adverse effect when combined with sodium phosphates
may increase the toxic effect of antipsychotics
may increase the toxic effect of Seizure Threshold, Lowering Potential agents
seizure lowering agents increase the toxic or adverse effects of iomeprol
When mephenytoin is aided by hesperetin, it reduces hesperetin’s metabolism
Actions and Spectrum
mephenytoin acts by stabilizing neuronal membranes, which reduces their excitability and prevents the rapid and excessive firing of neurons that can lead to seizures.
mephenytoin has a narrow therapeutic window which states that the difference between a safe and effective dose and a toxic dose is relatively small.
Frequency not defined
None
Black Box Warning
None
Contraindication/Caution:
None
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
mephenytoin might enhance the activity of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the brain.
GABA reduces neuronal excitability by hyperpolarizing the cell membrane, making it less likely for an action potential to occur.
Pharmacodynamics
mephenytoin exert its anticonvulsant effects by inhibiting voltage-gated sodium channels in neurons. Voltage-gated sodium channels play an important role in generating and propagating action potentials in neurons.
Pharmacokinetics
Absorption
mephenytoin is well-absorbed from the gastrointestinal tract.
Distribution
mephenytoin is distributed throughout the body.
Metabolism
mephenytoin undergoes metabolism primarily in the liver.
Elimination and excretion
mephenytoin are primarily excreted in the urine.
Administration
mephenytoin is administered orally in the form of tablets or capsules.
Patient information leaflet
Generic Name: mephenytoin
Why do we use mephenytoin?
mephenytoin is mainly used to treat epilepsy.
mephenytoin is used to manage various types of epileptic seizures, including partial seizures and generalized tonic-clonic seizures.
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