moxifloxacin ophthalmic

Action and Spectrum

Actions and Spectrum 

moxifloxacin ophthalmic works by inhibiting the activity of bacterial DNA gyrase and topoisomerase IV, enzymes that are essential for bacterial DNA replication, transcription, repair, and recombination.  

moxifloxacin ophthalmic has a broad-spectrum of activity against various gram-positive and gram-negative bacteria, including some drug-resistant strains. 

Drug Interaction

Adverse Reaction

Frequency defined  

1-10% 

Rash 

Subconjunctival hemorrhage 

Tearing 

Ocular discomfort 

Fever 

Rhinitis 

Otitis media 

Infection 

Ocular pruritus 

Pharyngitis 

Ocular pain 

Increased cough 

Ocular hyperemia 

Conjunctivitis 

Dry eye 

Black Box Warning

Black Box Warning 

None

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• moxifloxacin ophthalmic should not be used in individuals who have a known hypersensitivity or allergy to moxifloxacin. 

Caution: 

• Use moxifloxacin ophthalmic with caution in individuals with pre-existing eye conditions, such as glaucoma. 
• Patients should avoid excessive sunlight or artificial UV light exposure during treatment. 
• Prolonged or inappropriate use of moxifloxacin may result in overgrowth of non-susceptible bacteria or fungi. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

moxifloxacin ophthalmic disrupts the bacterial cell’s ability to replicate and divide results in leading to cell death or inhibition of bacterial growth. 

Pharmacodynamics 

moxifloxacin ophthalmic exhibits concentration-dependent bactericidal activity, meaning its killing effect on bacteria is directly related to the drug concentration at the site of action.   

Pharmacokinetics 

Absorption   

moxifloxacin ophthalmic is absorbed through the cornea and conjunctiva. 

Distribution 

moxifloxacin ophthalmic may distribute within the anterior chamber of the eye and surrounding tissues.  

Metabolism 

moxifloxacin ophthalmic undergoes hepatic metabolism.  

Elimination and excretion 

moxifloxacin ophthalmic drug is not excreted in the urine.  

Adminstartion

Administration 

moxifloxacin ophthalmic drug is available as eye drops or ointments for topical use.

Patient Information Leaflet

Patient information leaflet 

Generic Name: moxifloxacin ophthalmic  

Why do we use moxifloxacin ophthalmic? 

moxifloxacin ophthalmic is used to treat bacterial conjunctivitis.  

moxifloxacin ophthalmic is also effective in treating corneal ulcers caused by bacterial infections.