A Milestone Moment: FDA Approves Addyi® for Hypoactive Sexual Desire Disorder in Postmenopausal Women
December 17, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Naftomax, Nafodil
Synonyms :
naftopidil
Class :
BPH Agents, Bladder and Prostate Agents
Brand Name :
Naftomax, Nafodil
Synonyms :
naftopidil
Class :
BPH Agents, Bladder and Prostate Agents
Dosage Forms & Strengths
Tablet
25 mg
50 mg
75 mg
Benign Prostatic Hyperplasia (BPH)
Take a dose of 25 to 75 mg orally daily up to 4 weeks
Contraindicated
Refer to adult dosing
it increases the efficacy of hypotensive agents
it increases the efficacy of hypotensive agents
it increases the efficacy of hypotensive agents
it increases the efficacy of hypotensive agents
it increases the efficacy of hypotensive agents
may have an increased hypotensive effect when combined with anti-hypertensive agents
may have an increased hypotensive effect when combined with anti-hypertensive agents
may have an increased hypotensive effect when combined with anti-hypertensive agents
may have an increased hypotensive effect when combined with anti-hypertensive agents
may have an increased hypotensive effect when combined with anti-hypertensive agents
naftopidil: they may increase the hypotensive effect when combined with blood viscosity-reducing agents
naftopidil: they may increase the hypotensive effect when combined with blood viscosity-reducing agents
naftopidil: they may decrease the antihypertensive effect of antihypertensive agents
naftopidil: they may increase the CNS depressant effect of CNS Depressants
naftopidil: they may increase the CNS depressant effect of CNS Depressants
naftopidil: they may increase the CNS depressant effect of CNS Depressants
naftopidil: they may increase the CNS depressant effect of CNS Depressants
naftopidil: they may increase the CNS depressant effect of CNS Depressants
may increase the hypotensive effect of Blood Pressure Lowering Agents
Actions and Spectrum
naftopidil blocks alpha-1 adrenergic receptors, particularly the alpha-1A subtype, which are found in the smooth muscle of the prostate gland, bladder neck, and urethra.
Frequency not defined
Ejaculatory disorders
Buzzing or lightheadedness
Intraoperative floppy iris syndrome
Hypotension
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
naftopidil exerts its pharmacological effects by selectively blocking alpha-1 adrenergic receptors. These receptors are found in the smooth muscle of the prostate gland, bladder neck, and urethra.
Pharmacodynamics
By blocking the alpha-1A adrenergic receptors. naftopidil induces relaxation of the smooth muscle in these areas. This relaxation reduces the resistance to urine flow and helps to alleviate the obstruction caused by an enlarged prostate gland in patients with benign prostatic hyperplasia (BPH).
Pharmacokinetics
Absorption
naftopidil is absorbed from the gastrointestinal tract into the bloodstream.
Distribution
naftopidil is distributed throughout the body.
Metabolism
naftopidil undergoes metabolism primarily in the liver, where it is metabolized into various metabolites.
Elimination and excretion
naftopidil and its metabolites are excreted from the body through the urine.
Administration
naftopidil is typically available in the form of tablets and it is administered orally.
Patient information leaflet
Generic Name: naftopidil
Why do we use naftopidil?
naftopidil is used for the treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) in adult men. naftopidil is indicated for the management of lower urinary tract symptoms caused by BPH.
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
