Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Naftomax, Nafodil
Synonyms :
naftopidil
Class :
BPH Agents, Bladder and Prostate Agents
Brand Name :
Naftomax, Nafodil
Synonyms :
naftopidil
Class :
BPH Agents, Bladder and Prostate Agents
Dosage Forms & StrengthsÂ
Tablet Â
25 mg Â
50 mgÂ
75 mg Â
Benign Prostatic Hyperplasia (BPH)Â
Take a dose of 25 to 75 mg orally daily up to 4 weeks
ContraindicatedÂ
Refer to adult dosingÂ
it increases the efficacy of hypotensive agents
it increases the efficacy of hypotensive agents
it increases the efficacy of hypotensive agents
it increases the efficacy of hypotensive agents
it increases the efficacy of hypotensive agents
may have an increased hypotensive effect when combined with anti-hypertensive agents
may have an increased hypotensive effect when combined with anti-hypertensive agents
may have an increased hypotensive effect when combined with anti-hypertensive agents
may have an increased hypotensive effect when combined with anti-hypertensive agents
may have an increased hypotensive effect when combined with anti-hypertensive agents
naftopidil: they may increase the hypotensive effect when combined with blood viscosity-reducing agents
naftopidil: they may increase the hypotensive effect when combined with blood viscosity-reducing agents
naftopidil: they may decrease the antihypertensive effect of antihypertensive agents
naftopidil: they may increase the CNS depressant effect of CNS Depressants
naftopidil: they may increase the CNS depressant effect of CNS Depressants
naftopidil: they may increase the CNS depressant effect of CNS Depressants
naftopidil: they may increase the CNS depressant effect of CNS Depressants
naftopidil: they may increase the CNS depressant effect of CNS Depressants
may increase the hypotensive effect of Blood Pressure Lowering Agents
Actions and SpectrumÂ
naftopidil blocks alpha-1 adrenergic receptors, particularly the alpha-1A subtype, which are found in the smooth muscle of the prostate gland, bladder neck, and urethra.
Frequency not defined Â
Ejaculatory disordersÂ
Buzzing or lightheadednessÂ
Intraoperative floppy iris syndrome Â
HypotensionÂ
Black Box WarningÂ
None
Contraindication/Caution:Â
Contraindication:Â
Caution:Â
Pregnancy consideration:Â
Pregnancy category: N/AÂ
Lactation: Excretion into human milk is unknown Â
Pregnancy Categories:        Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.Â
Category N: There is no data available for the drug under this category.Â
Pharmacology Â
naftopidil exerts its pharmacological effects by selectively blocking alpha-1 adrenergic receptors. These receptors are found in the smooth muscle of the prostate gland, bladder neck, and urethra. Â
PharmacodynamicsÂ
By blocking the alpha-1A adrenergic receptors. naftopidil induces relaxation of the smooth muscle in these areas. This relaxation reduces the resistance to urine flow and helps to alleviate the obstruction caused by an enlarged prostate gland in patients with benign prostatic hyperplasia (BPH).Â
PharmacokineticsÂ
Absorption  Â
naftopidil is absorbed from the gastrointestinal tract into the bloodstream. Â
DistributionÂ
naftopidil is distributed throughout the body.Â
MetabolismÂ
naftopidil undergoes metabolism primarily in the liver, where it is metabolized into various metabolites. Â
Elimination and excretionÂ
naftopidil and its metabolites are excreted from the body through the urine.
AdministrationÂ
naftopidil is typically available in the form of tablets and it is administered orally. Â
Patient information leafletÂ
Generic Name: naftopidilÂ
Why do we use naftopidil?Â
naftopidil is used for the treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) in adult men. naftopidil is indicated for the management of lower urinary tract symptoms caused by BPH.Â
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