nedaplatin

Action and Spectrum

Actions and Spectrum 

nedaplatin exerts its anticancer effects by forming covalent crosslinks with DNA. These crosslinks interfere with DNA replication and transcription, ultimately leading to cell death. 

Drug Interaction

Adverse Reaction

Frequency not defined  

None 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Individuals who have a known hypersensitivity or severe allergic reaction to nedaplatin should not use this medication. 

Caution: 

• Patients with pre-existing kidney problems or impaired renal function may require dosage adjustments when using nedaplatin. 
• Patients with pre-existing neuropathy or other neurological conditions may require cautious use of nedaplatin. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

nedaplatin exerts its cytotoxic effects by forming covalent bonds with DNA. The formation of the DNA adducts interferes with DNA replication and transcription processes, leading to DNA strand breaks and triggering apoptosis. 

Pharmacodynamics 

The inability of cancer cells to repair the damage inflicted by nedaplatin leads to DNA strand breaks and triggers cellular signaling pathways that ultimately induce programmed cell death. 

Pharmacokinetics 

Absorption   

nedaplatin is administered intravenously i.e., directly introduced into the bloodstream. 

Distribution 

nedaplatin is distributed throughout the body.  

Metabolism 

nedaplatin undergo limited metabolism in the body.  

Elimination and excretion 

nedaplatin is eliminated from the body through renal excretion.

Adminstartion

Administration 

nedaplatin is administered intravenously, directly into your bloodstream through a vein.  

Patient Information Leaflet

Patient information leaflet 

Generic Name: nedaplatin 

Why do we use nedaplatin? 

nedaplatin is used in the treatment of testicular cancer.  

nedaplatin is also used in the treatment of non-small cell lung cancer.