penfluridol

Action and Spectrum

Actions and Spectrum 

penfluridol exerts its therapeutic effects through its antagonistic action on dopamine receptors. 

It reduces the activity of dopamine, a neurotransmitter that plays a significant role in regulating mood, behaviour, and perception.

Drug Interaction

Adverse Reaction

Frequency not defined  

Retention of urine 

Constipation 

Blurring of vision 

Dry mouth 

Weight gain 

Impaired glucose tolerance 

Orthostatic hypotension 

Allergic skin rashes 

Delirium 

Agitation  

Anxiety 

Cholestatic jaundice 

Extrapyramidal effects  

Depression 

Euphoria 

Anorexia  

Nausea 

Constipation 

Hypersalivation  

Vomiting 

Bronchospasm 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Individuals who have shown hypersensitivity to penfluridol or any of its components should not use the medication. 
• penfluridol is contraindicated in individuals with severe central nervous system depression. 

Caution: 

• Individuals with liver impairment may require dose adjustments. 
• Caution should be taken in individuals with severe renal impairment. 
• penfluridol should be used cautiously in individuals with a history of cardiovascular diseases. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

An antagonist of dopamine receptors, penfluridol helps reduce the overactivity of dopamine in the brain, which is implicated in the development of psychotic symptoms. This helps alleviate symptoms of schizophrenia and related psychotic disorders. 

Pharmacodynamics 

The pharmacodynamic effect of penfluridol is the reduction of positive symptoms of schizophrenia.  

By modulating dopamine signaling, penfluridol helps normalize brain activity and alleviate these symptoms. 

Pharmacokinetics 

Absorption   

penfluridol is absorbed from the gastrointestinal tract after oral administration.   

Distribution 

penfluridol is distributed throughout the body. 

Metabolism 

penfluridol undergoes hepatic metabolism through enzymatic pathways. 

Elimination and excretion 

penfluridol is eliminated from the body through the feces. 

Adminstartion

Administration 

penfluridol is administered orally in the form of tablets. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: penfluridol 

Why do we use penfluridol? 

penfluridol is indicated for the treatment of schizophrenia.  

penfluridol can also be used in the treatment of psychotic disorders.