pentoxyverine

Action and Spectrum

Actions and Spectrum 

pentoxyverine exerts its cough suppressant action by depressing the cough reflex centre in the brainstem. It does this by reducing the sensitivity of the sensory receptors in the airways and lungs that trigger the cough reflex.

Drug Interaction

Adverse Reaction

Frequency not defined  

Slight drowsiness 

Minor gastric disorders  

Skin rash 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• pentoxyverine should not be used in individuals who are known to be hypersensitive or allergic to the medication or any of its components. 
• pentoxyverine should not be used in individuals with severe respiratory depression. 

Caution: 

• Caution should be exercised when using it in combination with alcohol or other CNS depressants. 
• Individuals with impaired kidney or liver function need dose adjustments. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

pentoxyverine has anticholinergic properties, meaning it inhibits the activity of acetylcholine, a neurotransmitter. It can help reduce the activity of the parasympathetic nervous system, which is involved in stimulating bronchoconstriction and increased mucus secretion in the airways. 

Pharmacodynamics 

pentoxyverine has mild local anesthetic effects on the mucous membranes of the respiratory tract. This can help alleviate irritation and sensitivity of the cough receptors in the airways, leading to decreased coughing. 

Pharmacokinetics 

Absorption   

pentoxyverine is absorbed from the gastrointestinal tract into the bloodstream. 

Distribution 

pentoxyverine is distributed throughout the body.  

Metabolism 

pentoxyverine undergoes metabolism in the liver.  

Elimination and excretion 

pentoxyverine is excreted through the kidneys. 

Adminstartion

Administration 

pentoxyverine is administered orally and available in the form of tablet and suspension. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: pentoxyverine 

Why do we use pentoxyverine? 

pentoxyverine is mainly used to alleviate coughing associated with various respiratory conditions.   

pentoxyverine is used as cough suppressant to relieve cough caused by the common cold, flu, bronchitis, and sinusitis.