Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Regitine, OraVerse
Synonyms :
phentolamine
Class :
Alpha Blockers, Antihypertensives, Extravasation Antidotes
Brand Name :
Regitine, OraVerse
Synonyms :
phentolamine
Class :
Alpha Blockers, Antihypertensives, Extravasation Antidotes
Dosage Forms & Strengths
Powder (for injection)
5 mg
Solution
0.4mg/1.7ml
Administer dose of 5 mg for diagnosis via intravenously or intramuscularly
Dosage Forms & Strengths
Powder (for injection)
5 mg
Solution
0.4mg/1.7ml
Administer dose of 0.1 to 0.2 mg/kg intravenously/intramuscularly
Refer to adult dosingÂ
phentolamine: it may decrease the antihypertensive activities of bosentan
phentolamine: it may decrease the antihypertensive activities of bretylium
acebutolol: it may enhance the orthostatic hypotensive activities of phentolamine
aceclofenac: it may the therapeutic efficacy of phentolamine
acemetacin: it may decrease the therapeutic efficacy of phentolamine
acetylsalicylic acid: it may decrease the antihypertensive activities of phentolamine
alclofenac: it may decrease the therapeutic efficacy of phentolamine
aldesleukin: it may increase the risk of adverse with phentolamine
alfentanil: it may diminish the antihypertensive activities of phentolamine
bisoprolol: it may enhance the orthostatic hypotensive activities of phentolamine
brimonidine: it may increase the antihypertensive activities of phentolamine
bumetanide: it may increase the risk of adverse effects with phentolamine
dexibuprofen: it may decrease the therapeutic efficacy of phentolamine
dexketoprofen: it may decrease the therapeutic efficacy of phentolamine
dexmethylphenidate: it may decrease the antihypertensive activities of phentolamine
diazoxide: it may increase the hypotensive activities of phentolamine
dibenzepin: it may decrease the antihypertensive activities of phentolamine
Actions and SpectrumÂ
phentolamine blocks the action of alpha-adrenergic receptors. Alpha receptors are responsible for the constriction of blood vessels, and blocking these receptors leads to vasodilation, which is the relaxation and widening of blood vessels.
Frequency defined
1-10%
Injection site pain
Nasal congestion
Post-treatment pain
Diarrhea
Frequency not defined
Hypotension
Cardiac dysrhythmia
Chest pain
Myocardial infarction
None
Contraindication/Caution:
Contraindication:
Phentolamine must not be used in patients who have hypersensitivity or allergy to this drug.
Caution:
Phentolamine must be used with caution in patients who have low blood pressure or hypotension.
Phentolamine must be used with caution in patients who have peptic ulcers.
Phentolamine must be used with caution in patients who have cardiovascular diseases.
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:     
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
Phentolamine promotes vasodilation. This can relax and enlarge the blood vessels and reduces the resistance of peripheral vascular and reduces the blood pressure.
Pharmacodynamics
Phentolamine can reverse the effects of medication which can promote the α receptors. The vasodilation effects of this drug can lead to reduced blood pressure.
Pharmacokinetics
Absorption
Phentolamine is absorbed into the blood stream after the IV administration. It absorbs rapidly.
Distribution
Phentolamine is distributed to different tissues in the body.
Metabolism
Phentolamine goes to hepatic metabolism.
Elimination and excretion
Phentolamine is eliminated by renal pathway.
Phentolamine is administrated by IV bolus injection and IM injection.
Patient information leaflet
Generic Name: phentolamine
Why do we use phentolamine?
Phentolamine is used to diagnose and manage pheochromocytoma. It is a rare adrenal gland tumor. It can lead to excessive secretion of catecholamines. It is used to neutralize he effects of vasoconstrictive drugs which activate α receptors like α adrenergic agonists like epinephrine when these are given in excess.
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