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Brand Name :
N/A
Synonyms :
picosulfuric acid
Class :
Stimulant laxative
Limited information available
Not determined
lansoprazole, amoxicillin, and clarithromycin
antibiotics: they may decrease the therapeutic effect of sodium picosulfuric acid
antibiotics: they may decrease the therapeutic effect of sodium picosulfuric acid
antibiotics: they may decrease the therapeutic effect of sodium picosulfuric acid
antibiotics: they may decrease the therapeutic effect of sodium picosulfuric acid
antibiotics: they may decrease the therapeutic effect of sodium picosulfuric acid
Actions and Spectrum
As a laxative, picosulfuric acid works by irritating the intestines and inducing contractions in the muscles that push stool through the digestive tract.
Adverse reaction
None
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Hypersenstivity:
People allergic to picosulfuric acid or its components shouldn’t use it.
Caution:
Dehydration.
Gastrointestinal obstruction.
Appendicitis.
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
Bacterial enzymes convert picosulfuric acid to BHPM. BHPM targets the colon’s mucosa locally.
Pharmacodynamics
BHPM stimulates intestinal mucosa, boosting water and electrolyte secretion into the gut. This softens stool, easing passage.
Pharmacokinetics
Limited information available on ADME.
Administration
The route of administration is oral.
Patient information leaflet
Generic Name: picosulfuric acid
Why do we use picosulfuric acid?
Picosulfuric acid eases constipation by stimulating bowel movements. It’s also used to prep the colon for procedures like colonoscopy.