pipenzolate methylbromide/phenobarbitone

Action and Spectrum

Actions and Spectrum 

pipenzolate methylbromide is an antispasmodic drug. It belongs to a class of drugs known as anticholinergics. It works by blocking the action of acetylcholine, a neurotransmitter, at cholinergic receptors in various smooth muscles, including those in the gastrointestinal tract.  

phenobarbitone acts as a central nervous system depressant by enhancing the inhibitory effects of the neurotransmitter GABA (gamma-aminobutyric acid) in the brain. This results in a calming and sedative effect on the central nervous system.

Drug Interaction

Adverse Reaction

Frequency not defined  

Low blood pressure 

Lack of energy 

Depression 

Sores on skin or mouth ulcers 

Inflammation of tendons 

Memory problems 

Sensitivity to light 

Anemia 

Respiratory depression 

Hypotension 

Bruising or bleeding 

Aggression 

Lack of coordination or jerky movements 

Shedding of skin 

Swelling in the glands 

Fibromas 

Problems with concentrating 

Softening of bones 

Joint pain 

Mental confusion 

Impaired performance 

Rashes 

Swelling of eyelids 

Dizziness 

Fever or jaundice 

Phosphate or calcium in blood 

Hangover 

Loss of full control of bodily movements 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Do not use pipenzolate methylbromide/ phenobarbitone with a known hypersensitivity or allergy to this medication or any of its components. 

Caution: 

• Use pipenzolate methylbromide with caution in individuals with open-angle glaucoma. 
• Use phenobarbitone with caution in individuals with liver disease, as it can affect liver function. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

pipenzolate methylbromide blocks muscarinic receptors in smooth muscles in the gastrointestinal tract. It works by antagonizing the effects of the neurotransmitter acetylcholine on cholinergic receptors.  

phenobarbitone’s mechanism of action involves potentiating the inhibitory effects of gamma-aminobutyric acid (GABA) in the central nervous system. This leads to an overall reduction in neuronal excitability and a calming effect on the brain.  

Pharmacodynamics 

pharmacodynamic effect of pipenzolate methylbromide is to reduce spasms and hypermotility in the gastrointestinal tract. This results in decreased contractions and relief from abdominal pain and discomfort associated with conditions like irritable bowel syndrome (IBS). 

pharmacodynamic effect of phenobarbitone is its anticonvulsant action. By depressing brain activity, it reduces the severity of epileptic seizures. This makes it an essential medication in the treatment of epilepsy. 

Pharmacokinetics 

Absorption   

pipenzolate methylbromide/phenobarbitone is administered orally, and it is well-absorbed from the gastrointestinal tract. 

Distribution 

pipenzolate methylbromide/phenobarbitone is distributed throughout the body. 

Metabolism 

pipenzolate methylbromide/phenobarbitone undergoes metabolism in the liver. 

Elimination and excretion 

pipenzolate methylbromide/phenobarbitone are primarily excreted in the urine. 

Adminstartion

Administration 

pipenzolate methylbromide/phenobarbitone is a combination medicine available in form of drops for oral use.

Patient Information Leaflet

Patient information leaflet 

Generic Name: pipenzolate methylbromide/ phenobarbitone 

Why do we use pipenzolate methylbromide/ phenobarbitone? 

Piplar (pipenzolate methylbromide/ phenobarbitone) is a combination drug used in the treatment of epileptic seizures, gastrointestinal cramps, and spasms.It is also used in sedative, anticonvulsant, and flatulent dyspepsia conditions.