Microplastics and Misinformation: What Science Really Says
November 12, 2025
Brand Name :
Fal-DP
Synonyms :
piperaquine
Class :
Antiparasitic drug
Dosage Forms & StrengthsÂ
CapsuleÂ
500 mgÂ
750 mgÂ
1000 mgÂ
1500 mgÂ
(off-label)
Take a dose of 500 mg orally for three consecutive days
Not indicatedÂ
Refer to adult dosing
may enhance the risk of adverse effect of dapsone
piperaquine: they may increase the QTc-prolonging effect of QTc-prolonging Agents
piperaquine: they may increase the QTc-prolonging effect of QTc-prolonging Agents
piperaquine: they may increase the QTc-prolonging effect of QTc-prolonging Agents
piperaquine: they may increase the QTc-prolonging effect of QTc-prolonging Agents
piperaquine: they may increase the QTc-prolonging effect of QTc-prolonging Agents
CYP3A strong enhancers of the small intestine may reduce the bioavailability of piperaquine
piperaquine: they may enhance the serum concentration of CYP3A4 Inhibitors
piperaquine: they may enhance the serum concentration of CYP3A4 Inhibitors
piperaquine: they may enhance the serum concentration of CYP3A4 Inhibitors
piperaquine: they may enhance the serum concentration of CYP3A4 Inhibitors
piperaquine: they may enhance the serum concentration of CYP3A4 Inhibitors
Actions and SpectrumÂ
Action:Â
Piperaquine prevents the release of heme polymerization, which is caused when parasites break down haemoglobin. This accumulation of toxins disrupts detoxification and ultimately results in the death of the parasite.Â
Frequency not definedÂ
PalpitationsÂ
NauseaÂ
VomitingÂ
WeaknessÂ
Atrial arrhythmiasÂ
CoughÂ
BreathlessnessÂ
Black Box WarningÂ
NoneÂ
Contraindication/Caution:Â
Contraindication:Â
Hypersenstivity: People allergic to piperaquine or its components should avoid using it.Â
Caution:Â
Cardiac diseaseÂ
Liver dysfunctionÂ
PharmacologyÂ
Piperaquine prevents the release of heme polymerization, which is caused when parasites break down haemoglobin. This accumulation of toxins disrupts detoxification and ultimately results in the death of the parasite.Â
PharmacodynamicsÂ
The body’s level of piperaquine determines how effective it is against malaria; larger levels have a greater effect. The efficacy of piperaquine depends on blood concentrations remaining within therapeutic ranges.Â
PharmacokineticsÂ
Absorption
Piperaquine gets absorbed in the GI tract.Â
Distribution
Piperaquine binds strongly to plasma proteins.Â
MetabolismÂ
The metabolism occurs in the liver.Â
Excretion and Elimination
Piperaquine eliminated the body via feces and urine.Â
AdministrationÂ
The route of administration is oral.Â
Patient information leafletÂ
Generic Name: piperaquineÂ
Why do we use piperaquine?Â
Piperaquine treats and prevents malaria. It’s often combined with other antimalarial drugs like artemisinin in treatment.Â