piroctone olamine

Action and Spectrum

Actions and Spectrum: 

Action: 

Antifungal Activity: piroctone olamine exhibits antifungal properties, making it effective against various types of fungi, including Malassezia species. It is commonly used to treat dandruff and scalp conditions caused by fungal overgrowth. 

Sebum Regulation: In addition to its antifungal and antibacterial actions, piroctone olamine may help regulate sebum production, making it suitable for products targeting oily or acne-prone skin. 

Spectrum: 

Malassezia Fungi: piroctone olamine is particularly effective against malassezia species, which are known to be responsible for various skin conditions such as dandruff, seborrheic dermatitis, and fungal acne. 

Drug Interaction

Adverse Reaction

Frequency not defined  

wrinkling of skin 

asymmetry 

bruising 

bleeding 

numbness 

pain 

swelling 

Irritation 

Black Box Warning

Black Box Warning:  

None 

Contraindication / Caution

Contraindication/Caution:  

Allergic Reactions: Individuals with a known allergy or hypersensitivity to piroctone olamine or any of its related compounds should avoid products containing this ingredient. 

Open Wounds or Broken Skin: Applying piroctone olamine to open wounds, cuts, or broken skin is not recommended. It is meant for topical use on intact skin. 

Eyes and Mucous Membranes: Avoid contact with eyes, mouth, or other mucous membranes. In the event of unintentional contact, it is essential to thoroughly flush the affected area with water. 

Pregnancy and Breastfeeding: There may not be sufficient data to guarantee the safety of piroctone olamine during pregnancy and breastfeeding. Pregnant or breastfeeding individuals should seek guidance from a healthcare expert prior to utilizing products that include this ingredient. 

Children: Some products containing piroctone olamine may not be suitable for children or infants. Always read product labels and consult with a pediatrician before using on children. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excreted into human milk is unknown 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category  

Pharmacology

Pharmacology:

piroctone olamine is an antifungal and antimicrobial agent commonly used in various topical skincare and haircare products.  

Pharmacodynamics:  

Inhibition of Fungal Growth: piroctone olamine disrupts the fungal cell membrane and inhibits the synthesis of ergosterol, a crucial element found in the membranes of fungal cells. It disrupts the integrity of the fungal cell and hampers its growth and replication. 

Reduction of Inflammation: In addition to its antifungal properties, piroctone olamine may have anti-inflammatory effects, which can be beneficial in conditions where inflammation plays a role in the disease process.  

Pharmacokinetics: 

N/A 

Adminstartion

Administration:  

Before applying a piroctone olamine product, ensure the intended treatment area is clean and dry. This is particularly important for skincare products. When using it in haircare, you can apply it to wet hair. 

Depending on the product, apply a small amount of the piroctone olamine-containing product to the affected area or hair. The amount needed and the frequency of application will be specified on the product label. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: piroctone olamine 

Why do we use piroctone olamine?  

piroctone olamine is often included in anti-dandruff shampoos as it helps to control and prevent dandruff by reducing the growth of Malassezia, a yeast-like fungus associated with dandruff. 

Some facial cleansers, lotions, and creams contain piroctone olamine to combat acne. Its anti-microbial properties can help reduce the growth of acne-causing bacteria on the skin. 

Beyond dandruff control, piroctone olamine can also promote overall scalp health by preventing the overgrowth of microorganisms that may contribute to scalp irritation or odor.