Gepotidacin Gains FDA Priority Review for Breakthrough Oral Gonorrhea Therapy
December 13, 2025
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Brand Name :
Pivicil, Relexid, Selexid, Xsysto, Alexid, Vacilex, Emcil, Lexipen, Melysin, Panomax, Pivmecillinam
Synonyms :
pivmecillinam
Class :
Antibiotics & penicillin (beta-lactams)
Brand Name :
Pivicil, Relexid, Selexid, Xsysto, Alexid, Vacilex, Emcil, Lexipen, Melysin, Panomax, Pivmecillinam
Synonyms :
pivmecillinam
Class :
Antibiotics & penicillin (beta-lactams)
Dosage forms & Strengths
Tablet (film coated), Oral:
200 mg
20 - 40
mg/kg
Tablet
daily in 3 to 4 divided doses
Chronic Or Recurrent Bacteriuria
200
mg
Orally
twice a day
7
days
Or
200 mg orally thrice a day for 5 days
200
mg
Orally
twice a day
day for 7 days
Or
200 mg orally thrice a day for 5 days
Dosage forms & Strengths
Tablet (film coated), Oral:
200 mg
Chronic Or Recurrent Bacteriuria
For children > 40kg only: :
400
mg
3 to 4 times a day
Chronic Or Recurrent Bacteriuria
For children > 40kg only: :
400
mg
3 to 4 times a day
Chronic Or Recurrent Bacteriuria
For children > 40kg only: :
400
mg
3 to 4 times a day
For children > 40kg only::
20 - 40
mg/kg
Tablet
Orally
daily in 3 to 4 divided doses
Refer to adult dosing
tetracycline may decrease the therapeutic effects of penicillins by interfering with its bactericidal effects
tetracycline may decrease the therapeutic effects of penicillins by interfering with its bactericidal effects
Interaction with pivmecillinam may enhance the serum concentration of methotrexate
Interaction with pivmecillinam may enhance the serum concentration of methotrexate
Concomitant use of pivmecillinam and willow bark may result in increased levels of both drugs due to decreased renal clearance
acemetacin may increase the serum concentration of penicillins
penicillins may iincrease the anticoagulant effect of Vitamin K Antagonists
penicillins may decrease serum concentrations of the active metabolite(s) of mycophenolate
bismuth subcitrate, metronidazole and tetracycline
may decrease the therapeutic effect when combined with penicillins
may decrease the therapeutic effect when combined with penicillins
may decrease the therapeutic effect when combined with penicillins
may decrease the therapeutic effect when combined with penicillins
may decrease the therapeutic effect when combined with penicillins
Frequency defined:
>10% (significant):
Carnitine deficiency
>10% (Prolong use):
Acute porphyria
1% to 10% (Prolong use):
Thrombocytopenia
Vertigo
Nausea
Diarrhea
Vomiting
Abdominal pain
Oesophageal ulcer
Mouth ulceration
Fatigue
Rash
Dizziness
Headache
Pregnancy considerations: pivmecillinam can be assigned under pregnancy category D. Avoid during pregnancy.
Lactation: Pivmecillinam can be excreted in breast milk and may cause tooth discoloration in infants. Avoid use during breastfeeding.
Pregnancy category:
Patient information leaflet
Generic Name: Pivmecillinam
Pronunciation: Piv-mecill-inam
Why do we use pivmecillinam?
Pivmecillinam is a beta-lactam derivative antibiotic drug. It is used to treat bacterial infections.
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