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Brand Name :
GoEvac, CoLyte, GaviLyte-G, Glycolax, CoLav, GaviLyte-C, TriLyte, polyethylene glycol powder, polyethylene glycol electrolyte soln
Synonyms :
polyethylene glycol and electrolytes
Class :
Bowel preps, Osmotic Laxative
Brand Name :
GoEvac, CoLyte, GaviLyte-G, Glycolax, CoLav, GaviLyte-C, TriLyte, polyethylene glycol powder, polyethylene glycol electrolyte soln
Synonyms :
polyethylene glycol and electrolytes
Class :
Bowel preps, Osmotic Laxative
Adult:
Dosage Forms & StrengthsÂ
Oral powderÂ
850gÂ
527gÂ
510gÂ
255gÂ
238gÂ
119gÂ
Oral packetÂ
17g/packetÂ
sodium chloride/ potassium chloride/ sodium sulfate/sodium bicarbonateÂ
Powder for solutionÂ
5.84g/2.98g/22.72g/6.72g (240g)Â
5.86g/2.97g/22.74g/6.74g (236g)Â
5.53g/2.82g/21.5g/6.36g (227.1g)Â
sodium chloride/potassium chloride/ sodium bicarbonateÂ
powder for solutionÂ
11.2g/1.48g/5.72g (240g)Â
11.2g/1.48g/5.72g (420g)Â
Administer 240ml of powder for solution orally every 10 minutes until four liters are taken or until the rectal effluent is clear; rapid consumption of each measure is preferred over ingesting small quantities continuously.
NG: Administer 20 to 30ml/min until four liters are consumed or until the rectal effluent is clear
Oral powder: Administer 17g of the powder in 240 mL of liquid every 10 minutes until 2,000 mL is taken (start within 6 hours of providing magnesium citrate or bisacodyl delayed-release tablets).
Mix 17g of each packet in 120 to 240 mL (4 to 8 oz) daily.
Unless otherwise ordered by a doctor, discontinue usage if symptoms persist for more than two to four weeks.
Pediatirc:
Dosage Forms & StrengthsÂ
Oral powderÂ
850gÂ
527gÂ
510gÂ
238gÂ
255gÂ
119gÂ
Oral packetÂ
17g/packetÂ
Powder for solutionÂ
5.72g/11.2g/1.48g (420g)Â
<6 months: Safety and efficacy not established
>6 months: 25 mL/kg/hr O/NGT administered over 4 to 10 hours until the rectal effluent is clean; the maximum dosage is 4 L.
Neonates: Safety and efficacy not established
Adults, children, and infants: Administer 0.2 to 0.8g/kg/day orally
Do not exceed 17g/day
Do not administer for more than two weeks
<6 months: Safety and efficacy not established
>6 months: 25 mL/kg/hr O/NGT administered over 4 to 10 hours until the rectal effluent is clean; the maximum dosage is 4 L.
Neonates: Safety and efficacy not established
Adults, children, and infants: Administer 0.2 to 0.8g/kg/day orally
Do not exceed 17g/day
Do not administer for more than two weeks
 Geriatric:
Refer adult dosingÂ
May enhance the adverse/toxic effect of polyethylene Glycol-electrolyte Solution.
May enhance the adverse/toxic effect of polyethylene Glycol-electrolyte Solution.
May enhance the adverse/toxic effect of polyethylene Glycol-electrolyte Solution.
May enhance the adverse/toxic effect of polyethylene Glycol-electrolyte Solution.
sodium picosulfate, citric acid, and magnesium oxide
May enhance the adverse/toxic effect of polyethylene Glycol-electrolyte Solution.
may diminish the absorption when combined with iron preparation
may diminish the absorption when combined with iron preparation
may diminish the absorption when combined with iron preparation
may diminish the absorption when combined with iron preparation
It may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
It may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
It may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
It may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
It may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
spironolactone and hydrochlorothiazide
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
Actions and Spectrum:Â
The PEG electrolyte solution acts as osmotic laxative. When it is ingested, it creates an osmotic gradient in the GI tract and draw the water in the bowel and elevate the levels of fluid. This can make the stool soft and bulk up and facilitate the movement by the intestine and promote the bowel movement. It cleans the colon by flush out the stool and clear the GI tract. Â
The activity of PEG electrolyte solution covers the entire GI tract from stomach to colon. It removes the fecel material, debris or residue from the intestine and provide clear view for the diagnostic or surgical processes.Â
Adverse Reaction:
Frequency not definedÂ
Abdominal crampingÂ
Colonic mucosal aphthous ulcerationsÂ
FlatulenceÂ
NauseaÂ
Abdominal bloatingÂ
Abdominal distentionÂ
DiarrheaÂ
Ischemic colitisÂ
Post-marketing reportsÂ
Atrial fibrillationÂ
ArrhythmiaÂ
PruritusÂ
Urticaria/rashÂ
DermatitisÂ
Black box warning:Â
NoneÂ
Contraindications/caution:Â
Contraindications:Â
Caution:Â
Pregnancy / Lactation:
Pregnancy consideration: CÂ
Lactation: Excretion of the drug in human breast milk is unknownÂ
Pregnancy category:Â
Pharmacology:Â
Pharmacodynamics:Â
The pharmacodynamics of PEG-electrolyte solutions are primarily localized to the gastrointestinal tract. Their osmotic action and electrolyte balance properties help facilitate bowel cleansing and promote proper fluid balance.Â
Pharmacokinetics:Â
AbsorptionÂ
PEG-electrolyte solutions are not significantly absorbed from the gastrointestinal tract. Only a tiny fraction of the administered dose enters systemic circulation. The onset of action for PEG-electrolyte solutions typically occurs within 24-96 hours after ingestion. Â
DistributionÂ
It is mainly remain in the GI tract and help to clean the bowel and activate the bowel movement. The electrolytes are distributed in the body and maintain the electrolyte balance. Â
MetabolismÂ
PEG-electrolyte solutions go for minimal metabolism. It is not metabolized completely. It remains in unchanged form. The electrolytes like Na, K and CL go for normal metabolic process. Â
Elimination and ExcretionÂ
The main path of elimination is by feces. About 93% of the administrated dosage is excreted in feces. A small amount about 0.2 % is eliminated in urine. Â
Administration:Â
PEG-electrolyte solutions are mainly administered by orally. Before it is administrated, patient must be on fast for at least 3 to 4 hours. Encourage the patient to drink the water as soon as possible. Â
MiraLax: It is a measurement cup on the top of bottle label as 17 g.Â
Patient information leaflet:
Generic Name: polyethylene glycol and electrolytesÂ
Why do we use polyethylene glycol and electrolytes?Â
Bowel Preparation for Colonoscopy and other procedures: PEG-electrolyte solutions are mainly prescribed to clean the bowel before the procedures like colonoscopy or sigmoidoscopy and some surgery which include the GI tract.
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