Evaluating Blue Zones Demography in Response to Recent Critiques
January 6, 2026
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Brand Name :
GoEvac, CoLyte, GaviLyte-G, Glycolax, CoLav, GaviLyte-C, TriLyte, polyethylene glycol powder, polyethylene glycol electrolyte soln
Synonyms :
polyethylene glycol and electrolytes
Class :
Bowel preps, Osmotic Laxative
Brand Name :
GoEvac, CoLyte, GaviLyte-G, Glycolax, CoLav, GaviLyte-C, TriLyte, polyethylene glycol powder, polyethylene glycol electrolyte soln
Synonyms :
polyethylene glycol and electrolytes
Class :
Bowel preps, Osmotic Laxative
Adult:
Dosage Forms & Strengths
Oral powder
850g
527g
510g
255g
238g
119g
Oral packet
17g/packet
sodium chloride/ potassium chloride/ sodium sulfate/sodium bicarbonate
Powder for solution
5.84g/2.98g/22.72g/6.72g (240g)
5.86g/2.97g/22.74g/6.74g (236g)
5.53g/2.82g/21.5g/6.36g (227.1g)
sodium chloride/potassium chloride/ sodium bicarbonate
powder for solution
11.2g/1.48g/5.72g (240g)
11.2g/1.48g/5.72g (420g)
Administer 240ml of powder for solution orally every 10 minutes until four liters are taken or until the rectal effluent is clear; rapid consumption of each measure is preferred over ingesting small quantities continuously.
NG: Administer 20 to 30ml/min until four liters are consumed or until the rectal effluent is clear
Oral powder: Administer 17g of the powder in 240 mL of liquid every 10 minutes until 2,000 mL is taken (start within 6 hours of providing magnesium citrate or bisacodyl delayed-release tablets).
Mix 17g of each packet in 120 to 240 mL (4 to 8 oz) daily.
Unless otherwise ordered by a doctor, discontinue usage if symptoms persist for more than two to four weeks.
Pediatirc:
Dosage Forms & Strengths
Oral powder
850g
527g
510g
238g
255g
119g
Oral packet
17g/packet
Powder for solution
5.72g/11.2g/1.48g (420g)
<6 months: Safety and efficacy not established
>6 months: 25 mL/kg/hr O/NGT administered over 4 to 10 hours until the rectal effluent is clean; the maximum dosage is 4 L.
Neonates: Safety and efficacy not established
Adults, children, and infants: Administer 0.2 to 0.8g/kg/day orally
Do not exceed 17g/day
Do not administer for more than two weeks
<6 months: Safety and efficacy not established
>6 months: 25 mL/kg/hr O/NGT administered over 4 to 10 hours until the rectal effluent is clean; the maximum dosage is 4 L.
Neonates: Safety and efficacy not established
Adults, children, and infants: Administer 0.2 to 0.8g/kg/day orally
Do not exceed 17g/day
Do not administer for more than two weeks
Geriatric:
Refer adult dosing
May enhance the adverse/toxic effect of polyethylene Glycol-electrolyte Solution.
May enhance the adverse/toxic effect of polyethylene Glycol-electrolyte Solution.
May enhance the adverse/toxic effect of polyethylene Glycol-electrolyte Solution.
May enhance the adverse/toxic effect of polyethylene Glycol-electrolyte Solution.
sodium picosulfate, citric acid, and magnesium oxide
May enhance the adverse/toxic effect of polyethylene Glycol-electrolyte Solution.
may diminish the absorption when combined with iron preparation
may diminish the absorption when combined with iron preparation
may diminish the absorption when combined with iron preparation
may diminish the absorption when combined with iron preparation
It may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
It may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
It may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
It may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
It may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
spironolactone and hydrochlorothiazide
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
They may increase the nephrotoxic effect when combined with polyethylene Glycol-electrolyte Solution
Actions and Spectrum:
The PEG electrolyte solution acts as osmotic laxative. When it is ingested, it creates an osmotic gradient in the GI tract and draw the water in the bowel and elevate the levels of fluid. This can make the stool soft and bulk up and facilitate the movement by the intestine and promote the bowel movement. It cleans the colon by flush out the stool and clear the GI tract.
The activity of PEG electrolyte solution covers the entire GI tract from stomach to colon. It removes the fecel material, debris or residue from the intestine and provide clear view for the diagnostic or surgical processes.
Adverse Reaction:
Frequency not defined
Abdominal cramping
Colonic mucosal aphthous ulcerations
Flatulence
Nausea
Abdominal bloating
Abdominal distention
Diarrhea
Ischemic colitis
Post-marketing reports
Atrial fibrillation
Arrhythmia
Pruritus
Urticaria/rash
Dermatitis
Black box warning:
None
Contraindications/caution:
Contraindications:
Caution:
Pregnancy / Lactation:
Pregnancy consideration: C
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Pharmacology:
Pharmacodynamics:
The pharmacodynamics of PEG-electrolyte solutions are primarily localized to the gastrointestinal tract. Their osmotic action and electrolyte balance properties help facilitate bowel cleansing and promote proper fluid balance.
Pharmacokinetics:
Absorption
PEG-electrolyte solutions are not significantly absorbed from the gastrointestinal tract. Only a tiny fraction of the administered dose enters systemic circulation. The onset of action for PEG-electrolyte solutions typically occurs within 24-96 hours after ingestion.
Distribution
It is mainly remain in the GI tract and help to clean the bowel and activate the bowel movement. The electrolytes are distributed in the body and maintain the electrolyte balance.
Metabolism
PEG-electrolyte solutions go for minimal metabolism. It is not metabolized completely. It remains in unchanged form. The electrolytes like Na, K and CL go for normal metabolic process.
Elimination and Excretion
The main path of elimination is by feces. About 93% of the administrated dosage is excreted in feces. A small amount about 0.2 % is eliminated in urine.
Administration:
PEG-electrolyte solutions are mainly administered by orally. Before it is administrated, patient must be on fast for at least 3 to 4 hours. Encourage the patient to drink the water as soon as possible.
MiraLax: It is a measurement cup on the top of bottle label as 17 g.
Patient information leaflet:
Generic Name: polyethylene glycol and electrolytes
Why do we use polyethylene glycol and electrolytes?
Bowel Preparation for Colonoscopy and other procedures: PEG-electrolyte solutions are mainly prescribed to clean the bowel before the procedures like colonoscopy or sigmoidoscopy and some surgery which include the GI tract.
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