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Brand Name :
rabies vaccine human diploid cell culture, HDCV, Imovax Rabies
Synonyms :
rabies vaccine
Class :
Viral vaccines
Brand Name :
rabies vaccine human diploid cell culture, HDCV, Imovax Rabies
Synonyms :
rabies vaccine
Class :
Viral vaccines
Dosage forms and strengths Â
freeze-dried suspension, injectionÂ
≥2.5 IU/mLÂ
Indicated for Rabies Preexposure Immunization
Primary dose
Administer 1 ml in the deltoid area in three doses
The vaccine administration should be done on zero, seven, twenty-one & twenty eighth day
Booster dose Administer 1 ml intramuscularly in the deltoid area in order to continue serum titer greater than 1:5 RFFIT by serum dilution
Indicated for Rabies Postexposure Immunization
Individuals (unimmunized)
Administer 1 ml intramuscularly in five doses
The vaccine administration should be done on zero, three, seven, fourteen & twenty-eighth day in combination with HRIG on day zero
HRIG: Administer 20 IU/kg; the entire dosage should, if anatomically possible, be infiltrated around and into the wound(s), and any volume that is left over should be given intramuscularly in a location apart from where the vaccine is administered Individuals
(previously immunized)
Administer 1 ml intramuscularly in two doses on days zero & third
Dosage forms and strengths Â
freeze-dried suspension, injectionÂ
≥2.5 IU/mLÂ
Rabies Preexposure Immunization
Primary dose
Administer 1 ml intramuscularly in the deltoid area; in infants & children who are small, administration the three doses of vaccine in the thigh anterolateral region
The vaccine administration should be done on zero, seven, twenty-one & twenty eighth day
Booster dose
Administer1 ml intramuscularly in the deltoid area in order to continue serum titer greater than 1:5 RFFIT by serum dilution
Rabies postexposure Immunization
Individuals (unimmunized)
Administer 1 ml intramuscularly in five doses
The vaccine administration should be done on zero, three, seven, fourteen & twenty-eighth day in combination with HRIG on day zero
HRIG: Administer 20 IU/kg; the entire dosage should, if anatomically possible, be infiltrated around and into the wound(s), and any volume that is left over should be given intramuscularly in a location apart from where the vaccine is administered
Individuals (previously immunized)
Administer 1 ml intramuscularly in two doses on days zero & third
Refer adult dosingÂ
may decrease the therapeutic effect when combined with rabies vaccine
may decrease the therapeutic effect when combined with rabies vaccine
may decrease the therapeutic effect when combined with rabies vaccine
may decrease the therapeutic effect of corticosteroids
may decrease the therapeutic effect of rabies vaccine
may decrease the therapeutic effect of immunosuppressants
may decrease the therapeutic effect of immunosuppressants
may decrease the therapeutic effect
may decrease the therapeutic effect
may decrease the therapeutic effect of immunosuppressants
may decrease the therapeutic effect of immunosuppressants
may decrease the therapeutic effect of immunosuppressants
may increase the hypersensitivity reaction of immunosuppressants
may decrease the therapeutic effect of immunosuppressants
may decrease the therapeutic effect of immunosuppressants
may decrease the therapeutic effect of Immunosuppressants
may decrease the therapeutic effect of Immunosuppressants
antithymocyte globulin equineÂ
may decrease the therapeutic effect of Immunosuppressants
may decrease the therapeutic effect of Immunosuppressants
may decrease the effects of each other
may enhance the immunosuppressive effects of each other
When alefacept is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When anakinra is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When basiliximab is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When budesonide is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When cortisone is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When dexamethasone is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When fludrocortisone is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When golimumab is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When hydrocortisone is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When infliximab is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When leflunomide is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When methylprednisolone is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When mycophenolate is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When ocrelizumab is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When prednisolone is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When prednisone is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When rilonacept is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When sirolimus is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When tacrolimus is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When temsirolimus is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When tocilizumab is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
melphalan decreases the activity of rabies vaccine inactivated by antagonism.
immunosuppressants may decrease the therapeutic effect of live and attenuated vaccines
vaccines are not recommended, oncological agents may diminish the therapeutic effects of the vaccines
mercaptopurine on interacting with this vaccine decreases the vaccine's effect by antagonistic activity risk of infection increases on administering both the drugs simultaneously
may increase the hypersensitivity reactions of immunosuppressants
When azathioprine is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When canakinumab is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When etanercept is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When everolimus is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When glatiramer is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When cyclosporine is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When lomustine is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When melphalan is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When mercaptopurine is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When methotrexate is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When oxaliplatin is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
When ustekinumab is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
immunosuppressants decrease the efficacy of the rabies vaccine
immunosuppressants decrease the efficacy of the rabies vaccine
immunosuppressants decrease the efficacy of the rabies vaccine
immunosuppressants decrease the efficacy of the rabies vaccine
immunosuppressants decrease the efficacy of the rabies vaccine
Actions and Spectrum:Â
Action:Â
The action of the rabies vaccine involves stimulating the immune system to produce antibodies against the rabies virus. When a person is vaccinated against rabies, the vaccine introduces inactivated rabies virus particles or specific components of the virus. This exposure triggers the immune system to recognize these particles as foreign and produce antibodies to fight against them.Â
Frequency defined Â
>10%Â
Dizziness (20%)Â
Muscle aches (20%)Â
Abdominal pain (20%)Â
Nausea (20%)Â
Headache (20%)Â
Injection site reactions (25%)Â
1-10%Â
Serum sickness (7%)Â
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Severe Allergic Reaction (Anaphylaxis): A history of a severe allergic reaction (anaphylaxis) to a previous dose of the rabies vaccine or any of its components (such as neomycin, chlortetracycline, amphotericin B, and others) is a contraindication.Â
Altered Immunocompetence: Immunocompromised individuals, such as those undergoing immunosuppressive therapy or diagnosed with conditions that weaken the immune system, may need special consideration. The vaccine might not be as effective in these cases.Â
Acute Illness or Fever: Administration of the vaccine might be postponed if an individual is acutely ill or has a high fever. It’s better to wait until the illness resolves before getting vaccinated.Â
Previous Neurological Reactions: Individuals who have experienced neurological complications after a previous dose of rabies vaccine might need a careful risk-benefit assessment before receiving further doses.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: Â
The rabies vaccine is a biological preparation used to prevent rabies infection in individuals at risk of exposure to the rabies virus. It functions by inducing the production of antiviral antibodies by the immune system, thereby providing protection.Â
Pharmacodynamics:Â Â
The rabies vaccine stimulates the immune system to recognize and respond to the presence of the inactivated rabies virus by producing antibodies.Â
Upon administration, the immune system recognizes the viral antigens present in the vaccine as foreign invaders, initiating an immune response. Â
Pharmacokinetics:Â
N/AÂ
Administration: Â
The rabies vaccine is given in a series of shots to stimulate the immune system to produce antibodies against the rabies virus. The most used vaccines are the HDCV (human diploid cell vaccine) and PCEC (purified chick embryo cell vaccine). Adults receive the vaccination intramuscularly into the deltoid muscle, while children receive it into the anterolateral thigh muscle.Â
Patient information leafletÂ
Generic Name: rabies vaccineÂ
Why do we use rabies vaccine? Â
The rabies vaccine is primarily used as a preventive measure for people who are at high risk of exposure to rabies. This includes individuals who work in laboratories handling the rabies virus, veterinarians, animal control personnel, and people traveling to regions where rabies is prevalent.Â
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