Study Finds Birth Hypoxia May Increase ADHD Likelihood
January 27, 2026
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Brand Name :
Riabni
(United States) [Available] ,Rituxan
(United States) [Available] ,Ruxience
(United States) [Available] ,Truxima
(United States) [Available]Synonyms :
Chimeric antibody, Anti-human CD20 type
Class :
Antineoplastic agents: monoclonal antibodies
Brand Name :
Riabni
(United States) [Available] ,Rituxan
(United States) [Available] ,Ruxience
(United States) [Available] ,Truxima
(United States) [Available]Synonyms :
Chimeric antibody, Anti-human CD20 type
Class :
Antineoplastic agents: monoclonal antibodies
DOSAGE FORMS & STRENGTHS
may have an increased neutropenic effect when combined with deferiprone
may have an increased myelosuppressive effect when combined with ropeginterferon alfa-2b
may increase the Myelosuppressive effect of each other when combined
may diminish therapeutic effects of the vaccine, live virus vaccine with rituximab is not recommended
DMARDs may enhance the immunosuppressive effects of anifrolumab
may enhance the immunosuppressive effect of immunosuppressants
the risk of vaccine-associated infection may be increased
may enhance the immunosuppressive effects of DMARDs
increases the risk of serious infection due to immunosuppression rit
increases the risk of serious infection due to immunosuppression
increases the risk of serious infection due to immunosuppression
may enhance the risk of agranulocytosis and pancytopenia
may enhance the myelosuppressive effects of fexinidazole
increases the risk of serious infection due to immunosuppression
influenza virus vaccine quadrivalent intranasal
vaccine with the live virus is not recommended, may enhance the risk of vaccine-associated infections
increases the risk of serious infection due to immunosuppression
oncologic agents may enhance the immunosuppressive effects of natalizumab
may increase severe oral mucositis, avoid administration with or after 24 hrs of chemotherapy
oncologic agents may enhance the immunosuppressive effects of pimecrolimus
may enhance the risk of excessive bone marrow suppression
live vaccines are not recommended, oncological agents may diminish the therapeutic effects of live vaccines
live vaccines are not recommended, oncological agents may diminish the therapeutic effects of live vaccines
smallpox (vaccinia) vaccine live
live vaccines are not recommended, oncological agents may diminish the therapeutic effects of live vaccines
increases the risk of serious infection due to immunosuppression
live vaccines are not recommended, oncological agents may diminish the therapeutic effects of live vaccines
live vaccines are not recommended, oncological agents may diminish the therapeutic effects of live vaccines
live vaccines are not recommended, oncological agents may diminish the therapeutic effects of live vaccines
it increases the toxicity of varicella or rubella-containing live vaccines
in combination with ofatumumab, rituximab increases the risk of adverse events
myelosuppressive agents may diminish the therapeutic effect of BCG
may have an increased myelosuppressive effect when combined with fexinidazole
abiraterone acetate and niraparib
may increase the neutropenic effect of myelosuppressive agents
dipyridamole: it may decrease the therapeutic effect of myelosuppressive agents
olopatadine: it may decrease the therapeutic effect of myelosuppressive agents
paraldehyde: it may decrease the therapeutic effect of myelosuppressive agents
the interaction may increase the risk of nephrotoxicity and ototoxicity
interaction increases the risk of excessive immunosuppression
oncologic agents may diminish the therapeutic effects of brincidofovir
live vaccines are not recommended, oncological agents may diminish the therapeutic effects of live vaccines
may enhance adverse toxic effects of myelosuppressive agents
interaction may increase the risk of neutropenia
may enhance the risk of renal dysfunction due to nephrotoxicity and ototoxicity
live vaccines are not recommended, oncological agents may diminish the therapeutic effects of live vaccines
interaction increases the risk of excessive immunosuppression
may reduce therapeutic effects of Fc receptor-binding agents
interaction increases the risk of excessive immunosuppression
hepatitis A vaccine inactivated
vaccines are not recommended, oncological agents may diminish the therapeutic effects of the vaccines
vaccines are not recommended, oncological agents may diminish the therapeutic effects of the vaccines
vaccines are not recommended, oncological agents may diminish the therapeutic effects of the vaccines
vaccines are not recommended, oncological agents may diminish the therapeutic effects of the vaccines
oncologic agents may enhance the immunosuppressive effects of inebilizumab
the interaction may increase the risk of nephrotoxicity and ototoxicity
may increase immunosuppression and bone marrow suppression by pharmacodynamic synergism
miscellaneous immunosuppressants may enhance the immunosuppressive effects of ocrelizumab
may enhance the risk of bone marrow suppression
high risk of serious infection due to immunosuppression
oncologic agents may diminish the therapeutic effects of pidotimod
additive immunosuppressive effects may raise the risk of severe infections
may enhance the risk of myelosuppression
vaccines are not recommended, oncological agents may diminish the therapeutic effects of the vaccines
additive immunosuppressive effects may raise the risk of severe infections
diminish therapeutic effects of sipuleucel-T
may enhance the risk of infection due to neutropenia
vaccines are not recommended, oncological agents may diminish the therapeutic effects of the vaccines
it may enhance the adverse effects when combined with aducanumab
when both drugs are combined, there may be an increased risk or severity of adverse effects
It may increase the toxic effects of live vaccine
myelosuppressive Agents may enhance the adverse/toxic effect of clozapine
myelosuppressive Agents may enhance the myelosuppressive effect of Olaparib
myelosuppressive Agents may enhance the neutropenic effect of deferiprone
measles, mumps, rubella and varicella vaccine, live
may decrease the effects of rubella and varicella vaccine
may enhance the effect of myelosuppressive agents
may enhance the effect of myelosuppressive agents
may have an increased myelosuppressive effect when combined with myelosuppressive agents
may have an increased myelosuppressive effect when combined with olaparib
may have an increased adverse effect when combined with clozapine
may have an increased adverse effect when comb
may decrease the therapeutic effect when combined with BCG vaccine
may have an increased myelosuppressive effect when combined with myelosuppressive agents
may increase the toxic effect of myelosuppressive agents
It may enhance the risk of adverse effects when combined with Hormone Antagonists
ozanimod: it may decrease the therapeutic effect of myelosuppressive agents
tofacitinib: it may decrease the therapeutic effect of myelosuppressive agents
The immunosuppressive effect of immunosuppressants (cytotoxic chemotherapy) may be increased by denosumab
Actions and spectrum:
Rituximab’s mechanism and range are simple. It is an antibody with parts from human and mouse sources. One part targets CD20, a protein on B cells from the start. CD20 may help B cells work properly.
Frequency defined:
>10%:
Hypertension (12%)
Peripheral edema (16%)
Nightsweats (15%)
Pruritus (17%)
Skin rash
Weight gain
Abdominal pain
Diarrhea
Nausea
Anemia
Leukopenia
Neutropenia
Thrombocytopenia
Angioedema
Bacterial infection (19%)
Chills (33%)
Fatigue
Headache
Insomnia (14%)
Muscle spasm
Cough
Pulmonary toxicity
Upper respiratory infection
1% to 10%
Chest tightness
Urticaria
Hyperglycemia
Hyperuricemia
Vomiting
Urinary tract infection
Fungal infection
Viral infection
Anxiety
Dizziness
Migraine
Back pain
Sinusitis
Throat irritation
<1%
Hemolytic anemia
Black Box Warning
However, a caution note is vital. Using Rituximab may cause severe, life-threatening brain infections.
Contraindication/Caution:
Contraindication:
Breathing disorder
Heart rhythm disorder
Renal failure
Angina
Shingles
Chickenpox
Pregnancy/Lactation
Pregnancy: When a woman gets pregnant, a medicine called rituximab can be dangerous. It belongs to pregnancy category D. This drug might go through the mother’s placenta and harm the baby. Therefore, it shouldn’t be taken when expecting.
Lactation: Rituximab can also get into a mother’s breast milk. So, if a woman is breastfeeding, she must not use this medication. It may hurt the baby if taken while nursing.
Pregnancy category:
Pharmacology:
Rituximab works by pinpointing and destroying certain cells in the body. It treats particular kinds of cancer and autoimmune diseases. The medicine targets cells. It causes those specific cells to die. Rituximab is used for treating certain cancers. It also treats autoimmune diseases.
Pharmacodynamics:
Rituximab makes cells die in a few different ways. One is ADCC (antibody-dependent cell-mediated cytotoxicity). Another way is ADP (antibody-dependent phagocytosis). The last way is CDC (complement-mediated cytotoxicity). It works by messing up B cells in the immune system. This stops plasma cells from being made.
Pharmacokinetics:
Absorption
Rituximab achieves a peak of 157 mcg/ml after the first infusion. Then 183 mcg/ml following the second.
Distribution
It has a volume distribution of 3.1 liters.
Metabolism
As rituximab is a monoclonal antibody, it gets metabolized all over the body by proteases.
Elimination and excretion
Elimination primarily happens through the reticuloendothelial system. Antidrug antibodies form immune complexes, then endocytosed via Fcγ-mediated mechanisms to facilitate this. Rituximab’s half-life varies: 22 days for NHL, 32 for CLL, 18 for RA, and 22 for GPA and MPA.
Administration:
Rituximab is only given through IV infusion. Don’t give as bolus or push. For first infusion, start at 50 mg/hr. Raise 50 mg/hr every thirty minutes if no reactions, up to 400 mg/hr max. Later infusions start 100 mg/hr. Increase same way up to 400 mg/hr if tolerated. Young NHL/B-AL patients can increase faster — 0.5 mg/kg/hr more every thirty minutes from 0.5 mg/kg/hr start (max 50 mg/hr), up to 400 mg/hr max with no reactions.
Patient Information Leaflet:
Pronunciation: Rih-TUK-si-mab
Use: Rituximab treats certain cancers. For example, Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia. But it also helps autoimmune diseases, like Rheumatoid Arthritis. And Pemphigus Vulgaris too.
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