Genomic Study Maps Shared Risk Factors for 14 Psychiatric Disorders
December 14, 2025
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Brand Name :
Gantrisin, Gantrisin Pediatric, Truxazole
Synonyms :
Sulfadimethylisoxazole, Sulfafurazol, Sulfasoxazole, Sulfafurazolum
Class :
Sulfonamide Antibiotics, Folic acid synthesis inhibitors
Brand Name :
Gantrisin, Gantrisin Pediatric, Truxazole
Synonyms :
Sulfadimethylisoxazole, Sulfafurazol, Sulfasoxazole, Sulfafurazolum
Class :
Sulfonamide Antibiotics, Folic acid synthesis inhibitors
Dosage Forms & Strengths
Suspension, Tablets
500 mg
500 mg/5 mL
Sulfisoxazole is a sulfonamide antibiotic prescribed for treating certain bacterial infections
4000 to 8000 mg per day, divided and given in 4 – 6 doses daily
Dose Adjustments
Not Available
The usual adult dose required for treating this infection is 1 to 2 g of oral administration four times a day for 3 to 7 days
Dose Adjustments
Not available
Oral administration of 2 g is needed every 6 hours for 7 to 10 days, which is used as an adjunctive therapy in chloroquine-resistant Plasmodium falciparum
Dose Adjustments
Not Available
Oral administration of 2 g every 4 to 6 hours for at least six months
Immunocompromised patients require up to 1 year of this treatment
Dose Adjustments
Not Available
The usual adult dose required for treating this infection is 2 g of oral administration four times a day for 10 to 14 days
Dose Adjustments
Not Available
Oral administration of 500 mg 4 times a day for 21 days, where it is used in combination with ceftriaxone
Dose Adjustments
Not Available
The usual adult dose required for treating this infection is 2 g of oral administration four times daily for 14 days
Dose Adjustments
Not Available
Oral administration of 2 g 4 times a day, which is continued for 14 days approximately depending on the severity and nature of the infection
The usual adult dose required for treating this infection is 2 g of oral administration four times daily for 14 days
Dose Adjustments
Not Available
Oral administration of 2 g 4 times a day, which is continued for 14 days approximately depending on the severity and nature of the infection
Dose Adjustments
Not Available
The usual dose for the treatment is 75 mg/kg oral administration followed by 120 – 150 mg/kg/day in divided doses 4 or 6 times a day in infants two months or older
Dose Adjustments
Not Available
100 mg/kg/day oral administration in divided doses four times daily in infants two months or older where maximum dose should not cross 2 g per day
Dose Adjustments
Not Available
100 mg/kg/day of oral administration in divided doses four times a day, which is further recommended to be combined with ceftriaxone in infants two months or older
Dose Adjustments
Not Available
100 mg/kg/day of oral administration in divided doses four times a day, which is further recommended to be combined with ceftriaxone in infants two months or older
Dose Adjustments
Not Available
Refer to the adult dosing
sulfisoxazole serum concentration and reduced efficacy are seen in combination with methenamine
aminobenzoate potassium exhibits pharmacodynamic antagonism, resulting in reduced effects of sulfisoxazole
When halometasone is used together with sulfisoxazole, this leads to elevated risk or seriousness of hyperglycemia
the efficacy of acetohexamide can be increased with sulfisoxazole
combinational side effects will increase when methotrexate is used in combination with sulfisoxazole
sulfisoxazole will decrease the metabolism of warfarin
buserelin reduces the efficacy of sulfisoxazole when used in combination
methylprednisolone hemisuccinate
When methylprednisolone hemisuccinate is aided with sulfisoxazole, this leads to elevated hyperglycemia risk
Actions and Spectrum:
Actions:
sulfisoxazole is a sulfonamide antibiotic which is a bacteriostatic agent that inhibit bacterial synthesis of dihydrofolic acid. This inhibition occurs by preventing pteridine condensation with aminobenzoic acid via competitive inhibtion of the dihydropteroate synthetase enzyme.
Spectrum:
Spectrum of sulfisoxazole is similar to all sulfonamide group of antibiotics which cures bacterial infections of certain types like Cystitis, Inclusion Conjunctivitis, Trachoma, Malaria, Nocardiosis, Otitis Media, Pelvic Inflammatory Disease, Pyelobephritis, Toxoplasmosis, Meningitis -Meningococcal and Haemophilus influenzae in adults. In pediatrics, it is used in the treatment of Bacterial infections like Chlamydia infection, Toxoplasmosis, and pelvic inflammatory disease.
Frequency Not Defined
Shock
Serum sickness
Rash
Hives
Itching
Sensitivity to light
Liver inflammation
Jaundice
Nausea
Vomiting
Loss of apetitite
Abdominal pain
Diarrhea
Gastrointestinal bleeding
Mouth ulcer
Blood in urine
BUN and creatinine elevations
Anxiety
Chills
Cold sweats
Depression
Decreased sexual ability in males
Dizziness
Tachycardia
Headache
Changes in menstrual periods
Joint pain
Stroke
Cough
Shortness of breath
Fever
Drowsiness
Weakness
Fatigue
Sleeplessness
Lung inflammation
Black Box Warning:
sulfisoxazole should be stopped when skin rash appears first or any sign or symptom of any side effect is observed. Avoid excess dosage.
Contraindication/Caution:
Contraindications
Cautions
Pregnancy consideration:
No data is available regarding the administration of the drug during pregnancy.
Breastfeeding warnings:
No data is available regarding the excretion of drug in breast milk.
Pregnancy category:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
sulfisoxazole is a sulfonamide antibiotic which is a bacteriostatic agent that inhibit bacterial synthesis of dihydrofolic acid. This inhibition occurs by preventing pteridine condensation with aminobenzoic acid via competitive inhibtion of the dihydropteroate synthetase enzyme.
Pharmacodynamics:
sulfisoxazole is a sulfonamide antibiotic which is a bacteriostatic agent that inhibit bacterial synthesis of dihydrofolic acid. This inhibition occurs by preventing pteridine condensation with aminobenzoic acid via competitive inhibtion of the dihydropteroate synthetase enzyme.
Pharmacokinetics:
Absorption
sulfisoxazole is completely and rapidly absorbed in small intestine. The peak plasma concentration is 1 to 4 hours.
Distribution
Protein-bound is 85%
The volume of distribution of betrixaban is 36 L/kg
Metabolism
N-acetyl sulfisoxazole which is metabolized in the GIT to sulfisoxazole by digestive enzymes and is absorbed as sulfisoxazole.
Elimination and Excretion
The elimination half-life is 4.6 -7.8 hours
The drug is excreted 97% in urine.
Clearance is 20 ml/min.
Administration:
Exception in only congenital toxoplasmosis, sulfisoxazole is contraindicated in infants below 2 months of age in which therapy is adjunctive combined with pyrimethamine with pediatric starting dose of 150 mg/kg/day oral administration which is divided and given 4 times a day. Usual adult oral dose is 4000 to 8000 mg per day which is divided and given in 4 – 6 doses per day.
Patient information leaflet
Generic Name: sulfisoxazole
Pronounced: sul-fi-SOX-a-zole
Why do we use sulfisoxazole?
sulfisoxazole is used in the prevention and treatment of bacterial infections and it belongs to the group of sulfonamide antibiotic that helps in the prevention of bacterial growth and only available with doctors prescription.
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