thiamine

Action and Spectrum

Actions and Spectrum: 

Thiamine is crucial for energy production, neurotransmitter production, cell building, and cardiovascular health. It produces ATP, acetylcholine, DNA, RNA, supports nerve function, muscle contraction, and blood flow. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Anaphylaxis 

Warmth 

Diaphoresis 

Cyanosis 

Angioneurotic edema 

Restlessness 

Urticaria 

Pruritis 

Weakness 

Pulmonary edema 

Nausea 

Throat tightness 

Black Box Warning

Black Box Warning: 

None 

Contraindication / Caution

Contraindication/Caution: 

Allergy & Hypersensitivity 

Pregnancy / Lactation

Pregnancy consideration:  

Category A 

Breastfeeding warnings:  

The drug is safe during lactation. 

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   

• Category N: There is no data available for the drug under this category 

Pharmacology

Pharmacology: 

Thiamine is for energy metabolism and nerve function absorbed in the small intestine, metabolized in the liver, distributed, and excreted in urine with supplements available for treatment. 

Pharmacodynamics: 

Thiamine for energy metabolism, nerve function, DNA & RNA production, cardiovascular health, and alcoholism. Its cofactor enzymes like pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase converts food into ATP. It also aids in nerve function synthesizes neurotransmitters and maintains the myelin sheath. Thiamine deficiency can lead to Wernicke-Korsakoff syndrome. 

Pharmacokinetics: 

Absorption 

well absorbed through active transport mechanisms. 

Distribution 

Distributed throughout the body. 

Metabolism 

Metabolized in liver to its active form. 

Elimination and Excretion 

Excreted in urine. 

Adminstartion

Administration: 

Thiamine is available in oral tablets/capsules, injectable formulations, and IV infusions. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: thiamine 

Pronounced: thai-uh-meen 

Why do we use thiamine? 

Thiamine is utilized to treat thiamine deficiency, alcoholism, energy metabolism, cardiovascular and neurological health.