Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Vedrop
Synonyms :
d-alpha-tocopherol-polyethylene glycol 1000 succinate
Class :
Vitamin preparations, Vitamin E supplement
Data not availableÂ
Dosage Forms & StrengthsÂ
Oral solutionÂ
50mg/mlÂ
0.34
ml/kg
drops
Orally 
once a day
0.34 ml/kg, orally, once daily (17mg/kg- d-alpha-tocopherol)
Data not availableÂ
It may enhance the metabolism when combined with dexamethasone
the serum levels of tocofersolan may be raised when taken with abametapir
the rate of metabolism of tocofersolan may be reduced with amprenavir
the rate of metabolism of tocofersolan may be reduced with berotralstat
the rate of metabolism of tocofersolan may be reduced with boceprevir
the rate of metabolism of tocofersolan can be raised when taken with carbamazepine
the rate of metabolism of tocofersolan may be reduced with clarithromycin
the rate of metabolism of tocofersolan may be reduced with curcumin
the rate of metabolism of tocofersolan may be reduced with ciprofloxacin
the rate of metabolism of tocofersolan may be reduced with desvenlafaxine
the rate of metabolism of tocofersolan may be reduced with diltiazem
the rate of metabolism of tocofersolan may be reduced with elvitegravir
the serum levels of tocofersolan may be reduced with enzalutamide
the rate of metabolism of tocofersolan may be reduced with indinavir
the rate of metabolism of tocofersolan may be reduced with isavuconazole
the rate of metabolism of tocofersolan may be reduced with ketoconazole
the rate of metabolism of tocofersolan may be reduced with voriconazole
the rate of metabolism of tocofersolan may be reduced with zimelidine
the rate of metabolism of tocofersolan may be reduced with ziprasidone
side effects of digitoxin can be increased when calcimax syrup is used in combiantion
the rate of metabolism of tocofersolan may be reduced with amiodarone
Actions and spectrum:Â
The primary lipid-soluble antioxidant in the body is vitamin E. It prevents polyunsaturated fatty acid peroxidation by acting as a free radical, which is a chain-breaking molecule and contributes to the stability and integrity of cell membranes.Â
Frequency not definedÂ
Pain in the abdomenÂ
DiarrheaÂ
RashesÂ
PruritisÂ
HeadacheÂ
AlopeciaÂ
AstheniaÂ
Black Box Warning Â
To be used with caution in patients with hepatic failureÂ
Contraindication/Caution:Â
Contraindication:Â
HypersensitivityÂ
Not advised for use in preterm newborn babiesÂ
Pregnancy consideration:Â Â
USFDA pregnancy category:Â Â
Safety data not availableÂ
Lactation:Â Â
The excretion of tocofersolan into breast milk is not known.Â
Pregnancy category:Â Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus `in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology:Â
Pharmacodynamics:Â
This drug quickly enters cells due to its higher solubility, in contrast to other forms of vitamin E that are only fat-soluble. Because tocofersolan facilitates vitamin E absorption, it specifically normalizes vitamin E levels in cholestasis, alleviating deficiency symptoms.Â
Pharmacokinetics:Â
AbsorptionÂ
Tocofersolan has a unique bioavailability. At lower concentrations, it forms micelles, which assist in increasing the absorption of fat-soluble vitamins.Â
DistributionÂ
Tocofersolan has a wide range of distribution and is primarily bound to lipoproteins.Â
MetabolismÂ
Tocofersolan undergoes hydrolysis mainly in the gut lumenÂ
Elimination and excretionÂ
The drug is mainly excreted through bile and feces. A minimal amount of the drug is eliminated through urine.Â
Half-life:Â
29.7hoursÂ
Administration:Â
Tocofersolan is administered orally in the presence or absence of waterÂ
Patient information leafletÂ
Generic Name: tocofersolan Â
Why do we use tocofersolan?Â
Tocofersolan (vedrop) is recommended for pediatric patients with hereditary chronic cholestasis or congenital prolonged cholestasis from the time of birth (full-term newborns) to the age of 18 if they have a deficiency of vitamin E brought on by digestive malabsorption.Â
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