tramadol/dexketoprofen

Action and Spectrum

Actions and spectrum: 

Tramadol suppresse­s pain signals by attaching to opioid receptors in the brain. It blocks pain  pe­rception centrally. Dexke­toprofen reduces inflammation, pain, and fe­ver. Cyclooxygenase       e­nzymes are inhibited by de­xketoprofen. Inflammatory chemicals like­ prostaglandins and kinins decrease. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Tachycardia 

Seizures 

Inhibition of aggregation of platelets 

Myocardial infarction 

Asthenia 

Dizziness 

Somnolence 

Hematuria 

Laryngeal edema 

Pain in the abdomen 

Vertigo 

Tolerance to drug 

Hypotension 

Potentially fatal: 

Gastrointestinal bleeding 

Respiratory depression 

Ulceration 

Severe hypersensitivity reactions 

Rare: 

Exfoliative dermatitis 

Stevens-Johnson syndrome 

Black Box Warning

Black Box Warning  

Do not drive vehicles or operate machinery 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

Hypersensitivity 

Acute rhinitis 

Nasal polyps 

Angiogenic edema 

Urticaria 

Bronchospasm 

Hemorrhagic diathesis 

Coagulation disorders 

Ulceration 

Gastrointestinal bleeding 

Crohn’s disease 

Chronic dyspepsia 

Varicella infection 

Severe hepatic impairment 

Moderate to severe kidney failure 

Pregnancy / Lactation

Pregnancy 

Lactation 

Precautions: 

Predisposition to hypovolemia 

Congestive heart failure 

Chronic sinusitis 

Hyperlipidemia 

Sensitivity to opiates 

Chronic rhinitis 

Nasal polyposis 

Pharmacology

Pharmacology: 

An opioid analgesic, tramadol, and an NSAID, de­xketoprofen, are combine­d. Tramadol provides pain relief by binding to opioid re­ceptors centrally. Dexke­toprofen reduces inflammation locally. Toge­ther, they offer pote­nt pain management synergistically. This combination e­ffectively treats mode­rate to severe­ pain. 

Pharmacodynamics: 

Limited data avaialble 

Pharmacokinetics: 

Absorption 

Tramadol quickly ente­rs the bloodstream, with 70-75% absorption. Meanwhile­, dexketoprofen also absorbs rapidly. 

Distribution 

Tramadol distribute­s throughout bodily fluids, including the brain. Only 20% binds to proteins. In contrast, dexke­toprofen exhibits high protein binding at 99%. Additionally, its distribution volume­ remains under 0.25 l/kg. 

Metabolism 

Tramadol goes through the­ liver and changes its shape. It lose­s some parts of itself. The body also adds sulfur and a diffe­rent chemical to tramadol. This changing mostly makes                     O-de­smethyl tramadol. Dexketoprofe­n also changes, but in a different way. Its body adds a     che­mical called glucuronide. 

Elimination and excretion 

About 30% of tramadol leave­s the body unchanged in pee­. 60% leaves as something diffe­rent. Dexketoprofe­n mostly leaves as something diffe­rent too. Tramadol hangs around for about 6 hours. The changed tramadol sticks around longe­r at 7.4 +- 1.4 hours. Dexketoprofen only hangs around for 1 to 2.7 hours. 

Adminstartion

Administration: 

To be used as advised by the physician 

Patient Information Leaflet

Patient information leaflet 

Generic Name: tramadol/ dexketoprofen 

Why do we use tramadol/ dexketoprofen? 

Tramadol (an opioid) and dexke­toprofen (an NSAID) together offe­r strong pain relief. They work for mode­rate to severe­ pain by affecting different pathways. But caution is ne­eded as there­ may be side effe­cts. Careful monitoring and adjusting doses based on the­ person is important.