Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Syprine, Cuvrior
Synonyms :
triethylenetetramine
Class :
selective copper (II)-chelator
Brand Name :
Syprine, Cuvrior
Synonyms :
triethylenetetramine
Class :
selective copper (II)-chelator
Dosage forms and strengths Â
Oral CapsuleÂ
200 mgÂ
250 mgÂ
Tablet, film coated Â
150 MGÂ
300 mgÂ
Dosage forms and strengthsÂ
Oral CapsuleÂ
200 mgÂ
250 mgÂ
Tablet, film coated Â
150 MGÂ
300 mg/1Â
Tablet Â
150 mgÂ
Refer adult dosing
may decrease triethylenetetramine elimination, raising serum levels
aceclofenac Might lead to a reduction in the rate of excretion of triethylenetetramine, potentially leading to elevated levels of serum
abacavir Might lead to a reduction in the rate of excretion of triethylenetetramine, potentially leading to elevated levels of serum
acemetacin Might lead to a reduction in the rate of excretion of triethylenetetramine, potentially leading to elevated levels of serum
acetaminophen Might lead to a reduction in the rate of excretion of triethylenetetramine, potentially leading to elevated levels of serum
acetylsalicylic acid Might lead to a reduction in the rate of excretion of triethylenetetramine, potentially leading to elevated levels of serum
acyclovir Might lead to a reduction in the rate of excretion of triethylenetetramine, potentially leading to elevated levels of serum
adefovir dipivoxil Might lead to a reduction in the rate of excretion of triethylenetetramine, potentially leading to elevated levels of serum
the rate of excretion of inositol may be reduced
Action and SpectrumÂ
It is a chemical that have antioxidant property. It binds to iron and copper ions, forming stable complexes that the body can easily remove. By doing this, Trien helps to neutralize harmful free radicals, which are known to damage cells and tissues.Â
Frequency not defined
N/A
Black Box Warning:
None
Contraindication/CautionÂ
Allergic reactionÂ
Kidney impairmentÂ
Liver impairmentÂ
Neurological disordersÂ
Pregnancy warnings:Â Â Â
Pregnancy category: N/A
Lactation:Â Excreted into human milk is unknown
Pregnancy Categories:
Category A:Â Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C:Â there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D:Â adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X:Â Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N:Â There is no data available for the drug under this category
PharmacologyÂ
Triethylenetetramine has a specific characteristic. It binds to copper(II) in a way that allows the copper to be eliminated through the kidneys.Â
PharmacodynamicsÂ
It binds and chelates to copper ions forming stable complexes that are then excreted from the body. This decreases the amount of copper in tissues, particularly the liver and brain, which accumulate copper in a condition called Wilson’s disease.Â
PharmacokineticsÂ
AbsorptionÂ
Bioavailability-6% to 18%Â
DistributionÂ
Volume of distribution-654 litresÂ
MetabolismÂ
It is metabolised into acetyl form.Â
Elimination/ExcretionÂ
Elimination half-life:13.8 to 16.5 hours.Â
Clearance rate:69.5l/hÂ
AdministrationÂ
It sis administered orally in the form of tablets or capsules.Â
Patient information leafletÂ
Generic Name: triethylenetetramineÂ
Why do we use triethylenetetramine?Â
It is used in the treatment of Wilson’s disease, Alzheimer’s, and Parkinson’s. Preclinical research indicates that its antiproliferative and neuroprotective properties urge for more investigation.Â
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