Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
N/A
Synonyms :
Vindesine
Class :
Cytotoxic Chemotherapy
Brand Name :
N/A
Synonyms :
Vindesine
Class :
Cytotoxic Chemotherapy
Dosage Forms & Strengths
Adult
Powder for Solution
5 mg
Acute Lymphoblastic Leukemia(All)Â
Administer a dose of 3 to 4 mg/m2 intravenously weekly
Administer a dose of 3 to 4 mg/m2 intravenously weekly
Administer a dose of 3 to 4 mg/m2 intravenously weekly
Dosage Forms & Strengths
Powder for Solution
5 mg
Acute Lymphoblastic Leukemia(All)Â
Administer a dose of 4 to 5 mg/m2 intravenously weekly
it may increase the levels of serum concentration of OATP1B1/1B3 (SLCO1B1/1B3) Substrates
it may increase the levels of serum concentration of OATP1B1/1B3 (SLCO1B1/1B3) Substrates
it may increase the levels of serum concentration of OATP1B1/1B3 (SLCO1B1/1B3) Substrates
it may increase the levels of serum concentration of OATP1B1/1B3 (SLCO1B1/1B3) Substrates
it may increase the levels of serum concentration of OATP1B1/1B3 (SLCO1B1/1B3) Substrates
it may diminish the excretion rate when combined with vinca alkoloids, resulting in an enhanced serum level
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
when lenograstim is taken with vindesine, the risk or severity of peripheral neuropathy is raised
Action and Spectrum:
Vindesine interferes with microtubules, it is a structural component of the cell cytoskeleton. Microtubules present in cell division to prevent the formation of the mitotic spindle to inhibit cell division.
Adverse reaction
Frequency not defined
Convulsions
Abdominal pain
Jaw pain
Loss of deep tendon reflexes
Severe bronchospasm
Progressive dyspnoea
Foot drop
Nausea
Stomatitis
Black box warning:
None
Contraindications/caution:
Contraindications:
Hypersensitivity
Cautions:
Bone marrow function
Impaired liver or kidney function
Pregnancy Warnings:
Pregnancy category: N/A
Lactation: Excretion of the drug into the human breast milk is unknown
Pregnancy categories:
Pharmacology: Vindesine binds to tubulin and interferes with polymerization to prevent the formation of the mitotic spindle. It acts between the mitotic phase of the cell cycle.
Pharmacodynamics: Vindesine inhibits the normal process of mitosis in actively dividing cells. Their action is important in rapidly dividing cancer cells, that leads into antineoplastic effect.
Pharmacokinetic:
Absorption:
It has poor oral bioavailability.
Distribution
It distributes throughout the body.
Metabolism
It undergoes hepatic metabolism.
Elimination and excretion
It is excreted through the biliary system and feces.
Administration:
Vindesine is administered through intravenous route.
Patient information leaflet:
Generic Name: Vindesine
Why do we use Vindesine?
Vindesine is indicated in the treatment of breast carcinoma and malignant melanoma.
It is used in the treatment of acute lymphoblastic leukemia and acute myeloid leukemia.
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