From Erosion to Restoration: The ELR-Matrix Regenerates Human Enamel Structure and Function
Dental enamel is the hardest and most mineralized tissue in vertebrates. It is formed through the organized 3D assembly of amelogenin. It guides hierarchical nanocrystal growth, providing strength and resistance to thermal, physical, and chemical insults. This protective layer safeguards the teeth throughout life. However, enamel loss occurs due to trauma, acid erosion, or mechanical […]
Tele-exercise mobile app for patients with facial paralysis: development and usability study
BMC Neurol. 2025 Nov 5;25(1):454. doi: 10.1186/s12883-025-04403-1. ABSTRACT INTRODUCTION: Facial nerve paralysis is a neurological disorder in which the intentional movements of the patient’s facial muscles are completely or partially lost due to involvement of the seventh cranial nerve. Physiotherapy, especially exercise therapy plays an important role in restoring movement to the muscles. Thus, this […]
Impact of blood culture positivity at intensive care unit admission on mortality in infective endocarditis: Machine learning and deep learning-based causal inference models
PLoS One. 2025 Nov 6;20(11):e0333351. doi: 10.1371/journal.pone.0333351. eCollection 2025. ABSTRACT BACKGROUND: Infective endocarditis (IE) carries high in-hospital mortality, particularly among intensive care unit (ICU) patients. The predictive role of blood culture positivity in these patients remains unclear. METHODS: We analyzed 484 adult IE patients from the Medical Information Mart for Intensive Care III (MIMIC-III) database, […]
Parkinson’s disease severity clustering based on gait activity from mobile device
Sci Rep. 2025 Nov 6;15(1):38918. doi: 10.1038/s41598-025-22751-3. ABSTRACT Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor symptoms, including gait impairments, which significantly affect patient mobility and quality of life. An accurate assessment of the severity of PD is crucial for clinical management. This study investigates the utility of smartphone-derived gait data to objectively […]
The Future of Immunotherapy: Pioneering De Novo Antibody Design with RFdiffusion
The 2025 Nature publication “Atomically Accurate de novo Design of Antibodies with RFdiffusion” by Bennett et al. marks a groundbreaking development in computational approaches to antibody design. The researchers successfully demonstrated that antibodies can be designed entirely through computer modeling with atomic-level precision. Conventionally, the discovery of antibodies has been based on immunization, samples of patients, or screening of high-throughput […]
Does Fasting Fog Your Brain or Sharpen It? The Data Might Surprise You
Many people are reluctant to skip meals, especially breakfast, fearing it might leave them feeling foggy, irritable, or less productive. Advertisements and long-held beliefs have reinforced the notion that regular eating helps keep the mind sharp and focused. Nevertheless, intermittent fasting and time-restricted eating have grown in popularity over the last several years due to […]
WHO Acts on Global Health Funding Crisis
The World Health Organization (WHO) has released a new policy titled “Responding to the health financing emergency: immediate measures and longer-term shifts”. It provides strategies for countries to manage the severe consequences of sudden reductions in the external health funding. The guidelines provide both short-term and long-term policy options to stabilize the health systems, maintain […]
Revolutionizing Ultrasound: Multi-Lens Arrays Unveil 3D Microvascular Networks
Understanding microcirculation at the whole-organ level is crucial for diagnosing vascular diseases and improving treatment outcomes. Nevertheless, current imaging techniques have notable limitations. Computed tomography angiography (CTA) and photon-counting CT provide excellent anatomical detail but lack temporal resolution, whereas MRI offers dynamic flow imaging at a high cost and with limited accessibility. Traditional ultrasound, though […]
Evaluating the effectiveness of an mHealth application to promote home-based exercise in adults aged 65 years and older: protocol for a randomised controlled trial
BMJ Open. 2025 Nov 4;15(11):e106629. doi: 10.1136/bmjopen-2025-106629. ABSTRACT INTRODUCTION: With the global population ageing rapidly, older adults face increased risks of physical and cognitive decline. Despite the well-documented benefits of physical activity (PA), many older adults fail to meet PA guidelines. Mobile health (mHealth) apps offer promising tools to promote PA, but user engagement remains […]
Evaluation of post-keratoplasty status with a portable and smartphone-attachable smart eye camera
PLoS One. 2025 Nov 5;20(11):e0335450. doi: 10.1371/journal.pone.0335450. eCollection 2025. ABSTRACT PURPOSE: To evaluate the efficacy of the smart eye camera (SEC), a portable smartphone-attachable camera, in assessing eyes following lamellar corneal transplantation. METHODS: This retrospective study included consecutive patients who underwent lamellar corneal transplantation between December 1st 2023 and August 31st 2024. Postoperative evaluations were […]
