1 g IM or IV given every 12hrs for mild conditions
1-2 g IM or IV every 8hrs moderate to severe infections
2 g IV every 6-8hrs high dosing for infections
2 g IV every 4hrs for life-threatening infections
12 g is the maximum dose required per day
1-2 g IV or IM every 12hrs for moderate infections
2 g IV every 12hrs for Severe infections
3 g IV every 12hrs for Life-threatening infections
The maximum duration of therapy is 7-14 days
Renal Dose Adjustments:
No adjustment required
Liver Dose Adjustments:
No adjustment is recommended for Mild to moderate liver dysfunction
Severe liver dysfunction (Child-Pugh C):
1 mg/kg IV every 12 hours on 1st day
1 mg/kg IV every 24 hours on the 2nd day
maximum duration of treatment is 4-14 days
CrCl <15 ml/min: Do not use until haemodialysis is initiated
CrCl 15-29 ml/min:0.5g IV every 6 hours
CrCl 30-59 ml/min:0.75g IV every 6 hours
CrCl 60-89 ml/min:1g IV every 6 hours
The usual dose for the treatment of intraabdominal infection is 1 to 4 g via Intravenous or Intramuscular administration twice or thrice a day for up to 7 or 14 days. The duration of the treatment depends on the severity and the nature of the infections
If the infection is severe, the dose can be increased up to 12 g per day
Dose Adjustments
Renal Dose Adjustment In case of renal insufficiency, the usual dose of ceftizoxime depends on the CrCl. If the CrCl is below 5 mL/min, then 0.25-0.5 g a day or 0.5-1 g via IV or IM in 2 days after undergoing dialysis. Loading dose is standard in renal insufficiency, which is 0.5-1 g. 0.25 -1g twice a day if CrCl falls between 5 and 49 mL/min and 0.5 – 1.5 g thrice a day if CrCl is between 50 and 79 mL/min
Liver dose adjustments
In case of mild-to-moderate liver cirrhosis, use 200mg IV every day in contrast to 300mg IV for patients with normal hepatic clearance.
≥3 months: 20 mg/kg intravenous thrice a day; Do not exceed 1 g every 8 hours
<3 months:
Infants <32 weeks GA and PNA <2 weeks: 20mg/kg intravenous twice a day
Infants <32 weeks GA and PNA ≥2 weeks: 20 mg/kg intravenous thrice a day
Infants ≥32 weeks GA and PNA <2 weeks: 20 mg/kg intravenous thrice a day
Infants ≥32 weeks GA and PNA ≥2 weeks: 30 mg/kg intravenous thrice a day
Infuse intravenously for 30 minutes
<3 months: Safety and efficacy not established
3 to <6 months: Administer 50 mg/kg ( 40 mg/kg of ceftazidime and 10 mg/kg of avibactam) intravenously thrice daily for 5 to 14 days.
6 months to <2 years: Administer 62.5 mg/kg (50 mg/kg of ceftazidime and 12.5 mg/kg of avibactam) intravenously thrice a day for 5-14 days
2 years to <18 years: Administer 62.5 mg/kg(50 mg/kg of ceftazidime and 12.5 mg/kg of avibactam) intravenously thrice a day for 5-14 days; Do not exceed 2.5 g/dose
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