A Game-Changer for Diabetes: Polymer Delivers Insulin Painlessly Through Skin
November 25, 2025
Brand Name :
Differin
Synonyms :
Class :
Acne agents; Retinoids
Dosage forms & Strengths:Â
Adult:Â
Topical cream:Â
0.1%Â
Topical gel:Â
0.1%Â
0.3%Â
Topical lotion:Â
0.1%Â
Indicated as topical administration for acne vulgaris
After washing the face, apply the dosage form as a thin film on the affected area of the skin every evening
A warm sensation may occur on the skin after applying the same
In case of apparent worsening, do not discontinue the treatment
Apply the dosage form as a film on the affected area of the skin every evening
Not for children below 12 years
drospirenone/ethinyl estradiol/levomefolateÂ
may diminish the therapeutic effect of progestins
may increase the adverse effect of Multivitamins/Fluoride
it increases the toxicity of retinoic acid derivatives
It may enhance the risk of adverse effects when combined with oxazolidinones
It may enhance the risk of adverse effects when combined with oxazolidinones
bismuth subcitrate, metronidazole and tetracycline
may enhance the risk of adverse effect of retinoic acid derivatives
may enhance the risk of adverse effect of retinoic acid derivatives
may enhance the risk of adverse effect of retinoic acid derivatives
may enhance the risk of adverse effect of retinoic acid derivatives
may enhance the risk of adverse effect of retinoic acid derivatives
may increase the risk of adverse effects
l-methylfolate-pyridoxal 5′-phosphate-methylcobalamine
may increase the risk of adverse effects
bismuth subcitrate, metronidazole and tetracycline
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may enhance the adverse/toxic effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
retinoic acid derivatives decrease the efficacy of progestins
retinoic acid derivatives decrease the efficacy of progestins
retinoic acid derivatives decrease the efficacy of progestins
retinoic acid derivatives decrease the efficacy of progestins
retinoic acid derivatives decrease the efficacy of progestins
retinoic acid derivatives decrease the efficacy of progestins
>10%:Â
Dryness Â
Scaling Â
Burning/stinging Â
Erythema Â
1-10%:Â
Skin discomfort Â
Pruritus Â
DesquamationÂ
Sunburn Â
<1%:Â
Acne flareÂ
ConjunctivitisÂ
Contact dermatitisÂ
EczemaÂ
ErythemaÂ
Eyelid edemaÂ
RashÂ
Skin discolorationÂ
Adapalene is contraindicated in people hypersensitive to adapalene.Â
Pregnancy consideration:Â Â
Data obtained from clinical trials are insufficient.Â
Breastfeeding warnings:Â Â
Breastfeeding should be performed with caution, utilizing a limited area.Â
Pregnancy category:Â
Patient information leafletÂ
Generic Name: adapaleneÂ
Pronounced: a-DAP-a-leenÂ
Why do we use adapalene?Â
Adapalene treats acne vulgaris.Â