Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Optimine
Synonyms :
azatadine
Class :
Antihistamine
Brand Name :
Optimine
Synonyms :
azatadine
Class :
Antihistamine
Dosage forms and strengths Â
Oral tablet Â
1 mgÂ
Take 1-2 mg by oral route two times daily
Take 1-2 mg by oral route two times daily
Take 1-2 mg by oral route two times daily
Dosage forms and strengths Â
Oral tablet Â
1 mgÂ
Age more than or equal to 12 years
Take 1-2 mg by oral route two times daily
Age more than or equal to 12 years
Take 1-2 mg by oral route two times daily
Age more than or equal to 12 years
Take 1-2 mg by oral route two times daily
Refer adult dosingÂ
CNS stimulants: they may increase the CNS depressant effect of antihistamines
CNS stimulants: they may increase the CNS depressant effect of antihistamines
CNS stimulants: they may increase the CNS depressant effect of antihistamines
pitolisant: they may decrease the therapeutic effect of antihistamines
tiotropium: they may decrease the therapeutic effect of antihistamines
When ponesimod is used together with azatadine, this leads to enhanced risk or seriousness of bradycardia
When azatadine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When azatadine is used together with givinostat, this leads to enhanced risk or seriousness of Qtc prolongation
When azatadine is used together with profenamine, this leads to enhanced risk or seriousness of adverse events
azatadine: it may increase the risk or severity of QTc prolongation
azatadine: it may increase the risk or severity of QTc prolongation
azatadine: it may increase the risk or severity of QTc prolongation
azatadine: it may increase the risk or severity of QTc prolongation
azatadine: it may increase the risk or severity of QTc prolongation
the risk or extent of adverse effects can be raised when azatadine is combined with benzquinamide
may decrease the therapeutic effect of carbinoxamine
hyaluronidase: they may decrease the therapeutic effect of antihistamines
betahistine's therapeutic efficacy may be reduced by antihistamines
Itopride therapeutic efficacy may be reduced by antihistamines
atomoxetine: they may increase the stimulatory effect of antihistamines
sodium hyaluronate: they may diminish the therapeutic effect of antihistamines
glucagon: they may decrease the therapeutic effect of antihistamines
It may enhance the risk of adverse effects when combined with platelet Inhibitors
It may enhance the risk of adverse effects when combined with platelet Inhibitors
It may enhance the risk of adverse effects when combined with platelet Inhibitors
It may enhance the risk of adverse effects when combined with platelet Inhibitors
It may enhance the risk of adverse effects when combined with platelet Inhibitors
When azatadine is used together with aclidinium, this leads to enhanced risk or seriousness of adverse events
When azatadine is used together with alfentanil, this leads to enhanced risk or seriousness of adverse events
When azatadine is used together with amitriptyline, this leads to enhanced risk or seriousness of adverse events
When azatadine is used together with aripiprazole, this leads to enhanced risk or seriousness of adverse events
When azatadine is used together with atracurium, this leads to enhanced risk or seriousness of adverse events
the therapeutic activity of azacitidine may be reduced
the risk of adverse effects may be increased
Actions and Spectrum:Â
Action:Â
Antihistamine: azatadine primarily works as an H1 receptor antagonist. It blocks the action of histamine, a chemical released in the body during an allergic reaction. By binding to the histamine receptors (H1 receptors) in various tissues, including the nose, throat, and eyes, azatadine prevents histamine from exerting its effects. This action helps to alleviate allergy symptoms.Â
Spectrum:Â
Allergic Rhinitis: azatadine has been found to be a successful treatment for alleviating allergic rhinitis symptoms, which can include sneezing, a runny or itchy nose, and nasal congestion.Â
Frequency not defined Â
Disrupted coordinationÂ
DrowsinessÂ
Difficulty urinatingÂ
Dry mouthÂ
HeadacheÂ
DizzinessÂ
SleepinessÂ
FatigueÂ
Black Box Warning:Â Â Â
None
Contraindication/Caution:Â Â
Hypersensitivity: azatadine should not be used in individuals who have a known hypersensitivity or allergy to azatadine or any of its components. Â
Children Under 6 Years: azatadine is not generally recommended for use in children under the age of 6. The safety and effectiveness of azatadine in this age group may not be well established.Â
Pregnancy and Breastfeeding: The safety of azatadine during pregnancy and breastfeeding has not been well studied, Â
 seeking guidance from a healthcare professional is essential prior to the utilization of azatadine, particularly when pregnant or breastfeeding, to carefully assess the advantages and disadvantages.Â
Pregnancy warnings:    Â
Pregnancy category: BÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: azatadine is a first-generation antihistamine that is primarily used to relieve allergy symptoms.Â
Pharmacodynamics:Â Â
azatadine exerts its pharmacological effects by antagonizing the effects of histamine at H1 receptors. It is a selective H1 receptor antagonist, meaning it competes with histamine for binding to H1 receptors, thereby blocking the histamine-induced inflammatory response. By inhibiting H1 receptor activation, azatadine reduces the symptoms of allergic reactions. Â
Pharmacokinetics:Â
AbsorptionÂ
azatadine is well-absorbed from the gastrointestinal tract after oral administration.Â
DistributionÂ
It is widely distributed throughout the body, including the central nervous system.
It can traverse the blood-brain barrier, potentially resulting in central nervous system impacts like sedation.Â
MetabolismÂ
azatadine undergoes extensive first-pass metabolism in the liver. It is primarily metabolized into its active metabolite, desmethylazatadine.Â
Excretion and EliminationÂ
Both azatadine and its active metabolite are primarily excreted in the urine.Â
Administration: Â
azatadine is usually taken orally, with or without food. Follow the label instructions carefully before using.Â
Patient information leafletÂ
Generic Name: azatadineÂ
Why do we use azatadine? Â
azatadine is commonly employed to relieve the manifestations of allergic rhinitis such as congested nose, itchiness, and teary eyes resulting from sensitivities to substances like pollen, dust mites, animal dander, or various environmental allergens.Â
azatadine may be prescribed to relieve the itching and hives associated with chronic idiopathic urticaria.Â
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