Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
N/A
Synonyms :
boceprevir
Class :
Protease inhibitors
Brand Name :
N/A
Synonyms :
boceprevir
Class :
Protease inhibitors
Dosage Forms & Strengths
Capsule
200 mg
Take a dose of 800 mg orally thrice daily (with a gap of 7 to 9 hours between each dose) along with meal
Contraindicated
Refer to adult dosing
when both drugs are combined, there may be a decreased metabolism of vinblastine  
when both drugs are combined, the metabolism of paclitaxel decreases when compared with boceprevir  
when both drugs are combined, there may be an increased risk or severity of adverse effects  
When alprazolam and boceprevir is used together, this leads to reduction in the alprazolam’s metabolism
When boceprevir is used together with fluconazole, this leads to reduction in the boceprevir metabolism
boceprevir: it may increase the risk of CNS depression
boceprevir: it may increase the risk of CNS depression
boceprevir: it may increase the risk of CNS depression
boceprevir: it may increase the risk of CNS depression
boceprevir: it may increase the risk of CNS depression
boceprevir: it may decrease the therapeutic efficacy of etynodiol
boceprevir: it may increase the serum concentration of gestodene
boceprevir: it may decrease the therapeutic efficacy of dextropropoxyphene
the metabolism of digitoxin can be diminished when combined with boceprevir
tenofovir disoproxil fumarate or tenofovir DFÂ
monitoring of patients who develop TDF-associated adverse reactions in which tenofovir levels increase when taken along with Hepatitis C Antiviral Drugs. If TDF-associated adverse reactions emerge, discontinue tenofovir DF in patients who develop them
the rate of metabolism of tocofersolan may be reduced with boceprevir
When boceprevir is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
Actions and Spectrum
boceprevir inhibits the activity of the HCV NS3/4A protease enzyme, which plays a crucial role in viral replication. HCV protease is responsible for cleaving viral polyproteins into individual functional proteins necessary for viral replication.
boceprevir specifically targets hepatitis C virus (HCV). It is effective against specific genotypes of HCV, particularly genotype 1.
Frequency not defined
Nausea
vomiting
Taste disturbances
Blood dyscrasias
Anemia
Fatigue
Cerebral and retinal ischemia
Cholecystitis
Increased incidence of infection
Headache
Dry eyes
Dehydration
Metabolic disturbances
Thyroid disturbances
Reduced appetite and weight loss
Palpitations
Cardiac arrhythmias
Thrombotic disorders
Pleural fibrosis and pleuritic pain
Changes in blood pressure
Thyroid neoplasms
Retinopathy
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category:
X: When used as combination with ribavirin and peginterferon alfa
B: As monotherapy
Lactation: Excretion into human milk is unknown
Pregnancy Categories:     
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
boceprevir specifically targets the NS3/4A protease enzyme of the hepatitis C virus. By inhibiting the NS3/4A protease, boceprevir disrupts the viral replication process, leading to decrease in viral load.
Pharmacodynamics
Prolonged use of boceprevir as monotherapy or in a suboptimal regimen can lead to the development of drug-resistant variants of the hepatitis C virus.
boceprevir is used in combination with other direct-acting antiviral agents.
Pharmacokinetics
Absorption
boceprevir is rapidly absorbed from the gastrointestinal tract.
Distribution
boceprevir is extensively distributed in the body after absorption.
Metabolism
boceprevir undergoes extensive hepatic metabolism by the cytochrome P450 enzyme CYP3A4.
Elimination and excretion
boceprevir is primarily excreted in the feces. The elimination half-life of boceprevir ranges from approximately 3 to 5 hours.
Administration
boceprevir is usually administer orally and it is available in the form of capsules.
Patient information leaflet
Generic Name: boceprevir
Why do we use boceprevir?
boceprevir is used in the treatment of chronic hepatitis C virus (HCV) infection.
boceprevir was specifically indicated for the treatment of HCV genotype 1 infection in combination with pegylated interferon and ribavirin.
It is administered in individuals with compensated liver illness including cirrhosis, who have not undergone prior treatment.
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