ADHD Treatments Under the Spotlight: Weighing Benefits and Harms
November 28, 2025
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Brand Name :
Eohilia
(United States) [Available] ,Tarpeyo
(United States) [Available] ,Uceris
(United States) [Available]Synonyms :
budesonide
Class :
Anti-asthmatic, Anti-inflammatory, Glucocorticoids, Inhaled corticosteroids
Dosage forms and strength:
Capsule (extended release)
6 mg
9 mg
Capsule (delayed release)
3 mg
4 mg
Tablet
9 mg
Administer a dose of 360 mcg through inhalation twice daily
Administer a dose of 9 mg orally once daily in the morning for up to 8 weeks
Dosage forms and strength:
Capsule (extended release)
6 mg
9 mg
Capsule (delayed release)
3 mg
4 mg
Tablet
9 mg
For >8 years old:
Take a dose of 9 mg orally once daily in the morning for up to 8 weeks then take dose of 6 mg once daily for 2 weeks
budesonide: they may enhance the serum concentration of CYP3A Inhibitors
budesonide: they may enhance the serum concentration of CYP3A Inhibitors
budesonide: they may enhance the serum concentration of CYP3A Inhibitors
budesonide: they may enhance the serum concentration of CYP3A Inhibitors
budesonide: they may enhance the serum concentration of CYP3A Inhibitors
may enhance the risk of hyperglycemia when combined with Budesonide
the excretion rate of oxybenzone may be decreased by budesonide, leading to increased serum levels of oxybenzone
The presence of budesonide can impact the hepatic/intestinal enzyme CYP3A4 metabolism, leading to a reduction in the level or effectiveness of intranasal dihydroergotamine
may enhance the concentration of serum when combined with budesonide
may enhance the concentration of serum when combined with budesonide
may enhance the concentration of serum when combined with budesonide
may enhance the concentration of serum when combined with budesonide
may enhance the concentration of serum when combined with budesonide
may have a decrease in excretion rate when combined with tetradecyl sulfuric acid
When budesonide is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
when budesonide is used in combination with diphtheria & tetanus toxoids, this leads to a reduction in the effects of diphtheria & tetanus toxoids through pharmacodynamic antagonism
the effect of nivolumab decreases on interacting with budesonide.
may enhance the serum concentration of CYP3A4 inhibitors
pneumococcal vaccine polyvalent
the activity of pneumococcal vaccine polyvalent is reduced due to pharmacodynamic antagonism
may enhance the serum concentration of nirmatrelvir and ritonavir
It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4
it may enhance the metabolism when combined with zuclopenthixol
It may enhance the effect when combined with miconazole vaginal by affecting CYP3A4 metabolism
budesonide has the potential to reduce the rate of excretion of idebenone, leading to an elevation in levels of serum
When budesonide is used together with fluconazole, this leads to reduction in the budesonide metabolism
tinidazole has the potential to reduce the rate of excretion of budesonide, potentially leading to an elevation in level of serum
When mometasone furoate is used together with budesonide, this leads to enhanced risk or seriousness of adverse outcomes
budesonide leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of budesonide which leads to increased level of serum
budesonide leads to a reduction in the rate of excretion of chromous sulfate, which leads to an increased level of serum
budesonide leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
budesonide leads to a reduction in the rate of excretion of potassium acetate, which leads to an increased level of serum
budesonide leads to a reduction in the rate of excretion of potassium perchlorate, which leads to an increased level of serum
budesonide: it may decrease the excretion rate of iothalamic acid
When budesonide is used together with oleandomycin, this leads to enhanced concentration serum of budesonide
When budesonide is used together with ridaforolimus, this leads to enhanced concentration serum of budesonide
the chances of cholecalciferol's effectiveness in therapy may diminish when used concurrently with budesonide
When budesonide is used in combination with profenamine, this leads to reduction in therapeutic effectiveness of profenamine
budesonide: it may increase the therapeutic efficacy of etynodiol
budesonide's bioavailability may be reduced when combined with almasilate
when both drugs are combined, there may be an increased risk of adverse effects
metronidazole enhances the effect of budesonide by altering the intestinal or hepatic CYP3A4 enzyme metabolism
may diminish the amount of P-glycoprotein (MDR1) efflux transporter
the rate of metabolism of dihydroergocornine may be increased
the risk of adverse effects can be increased
When budesonide is used together with lomitapide, this leads to an enhancement in lomitapide’s metabolism
the toxicity of either of the drugs is increased when administered together due to pharmacodynamic synergism
budesonide might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
When budesonide is aided by androstenediol, that promotes an increased risk of edema
the risk of hyperglycemia may be enhanced
it decreases the effect or level of finasteride by altering the intestinal/hepatic enzyme CYP3A4 metabolism
it decreases the effect or level of dutasteride by altering the intestinal/hepatic enzyme CYP3A4 metabolism
Actions and spectrum:
Budesonide is a potent topical anti-inflammatory agent which works by binding and activating glucocorticoid receptors within effector cells like bronchial cells.
This complex hinders the production of inflammatory genes which prevents bronchoconstriction by inhibiting gene transcription.
Frequency defined:
>10%
Otitis media
Respiratory infection
Rhinitis
1%-10%
Syncope
Chest pain
Headache
Pain
Skin rash
Fatigue
Pruritus
Weight gain
Dyspepsia
Conjunctivitis
Post marketing report
Adrenocortical insufficiency
Bruise
Depression
Glaucoma
Growth suppression
Anxiety
Black Box Warning:
None
Contraindications and caution:
Contraindications
Hypersensitivity
Acute bronchospasm
Status asthmaticus
Cautions:
Fungal infections
Viral infections
Bacterial infections
Herpes simplex virus
Pregnancy Warnings:
Pregnancy category: N/A
Lactation: Excretion of the drug into the human breast milk is unknown
Pregnancy categories:
Pharmacology:
Budesonide is a synthetic corticosteroid which exhibits potent glucocorticoid and mild mineralocorticoid activities. It has an active anti-inflammatory component in certain nasal inhalers.
Pharmacodynamics:
Budesonide enhances apoptosis in eosinophils and inhibits the activation of inflammatory cells which results in decreased airway inflammation. The overall suppression of TNF and ILs reduces airway hyperreactivity and wheezing thus effectively inhibiting bronchospasm and coughing.
Pharmacokinetics:
Limited information is available on ADME.
Administration:
Budesonide is taken as a powder form for inhalation and as a suspension for inhalation through a special jet nebulizer.
Patient information leaflet
Generic Name: budesonide
Why do we use budesonide?
It is used to treat mild to moderate Crohn’s disease in adults and children.
It is used to treat mild to moderate ulcerative colitis in adults.
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