The Navigation Model of Therapy: Why Awareness Changes Everything
November 16, 2025
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Brand Name :
Spectracef
Synonyms :
Cefditoren
Class :
3rd generation Cephalosporins
Brand Name :
Spectracef
Synonyms :
Cefditoren
Class :
3rd generation Cephalosporins
Dosage forms and strengthÂ
TabletÂ
200mgÂ
400mgÂ
Exacerbation of chronic bronchitis by acute bacteria Take 400 mg orally after every 12 hours up to 10 days
Take 400 mg orally after every 12 hours up to 14 days.
Take 200 mg orally after every 12 hours up to 10 days
Renal Impairment
For creatinine clearance of 30 to 49 ml/minute/1.73 square meter: maximum up to 200 mg orally after every 12 hours
For creatinine clearance of <30 ml/minute/1.73/square meter: every day 200 mg orally
End-stage: dose not determined yet
Dosage Forms & StrengthsÂ
<12 years: Safety and efficacy not establishedÂ
>12 years: Refer adult dosingÂ
Refer to adult dosing
antacids decrease the concentration of cefditoren in serum
antacids decrease the concentration of cefditoren in serum
antacids decrease the concentration of cefditoren in serum
antacids decrease the concentration of cefditoren in serum
antacids decrease the concentration of cefditoren in serum
cefditoren: they may diminish the serum concentration of antacids
cefditoren: they may diminish the serum concentration of antacids
cefditoren: they may diminish the serum concentration of antacids
cefditoren: they may diminish the serum concentration of antacids
cefditoren: they may diminish the serum concentration of antacids
antacids can reduce the amount of cefditoren present in the bloodstream
antacids can reduce the amount of cefditoren present in the bloodstream
may diminish the absorption of Antacids
it may diminish the excretion rate when combined with estradiol valerate resulting in a greater serum level
it may enhance the risk of nephrotoxicity when combined with phenylbutazone
may have an increased nephrotoxic effect when combined with aminoglycosides
neomycin/polymyxin B/bacitracin topical
may have an increased nephrotoxic effect when combined with aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
When cefditoren is used together with piroxicam, this leads to increased risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefditoren, this leads to enhanced risk or seriousness of nephrotoxicity
When cefditoren is used together with proglumetacin, this leads to enhanced risk or seriousness of nephrotoxicity
When cefditoren is used together with benoxaprofen, this leads to enhanced risk or seriousness of nephrotoxicity
cefditoren leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
When cefditoren is used together with aluminium phosphate, this leads to a reduction in the concentration serum of cefditoren
When cefditoren is used together with bismuth subnitrate, this leads to a reduction in the concentration serum of cefditoren
cefditoren leads to a reduction in the rate of excretion of chromous sulfate, which leads to an increased level of serum
cefditoren leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
cefditoren leads to a reduction in the rate of excretion of potassium perchlorate, which leads to an increased level of serum
cefditoren leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
When cefditoren is used together with difenpiramide, this leads to enhanced risk or seriousness of nephrotoxicity
cefditoren's serum concentration may be reduced when it is combined with almasilate
When both drugs are combined, there may be an increased risk or severity of adverse effects  
demeclocycline reduces the effects of bactericidal agents
doxycycline reduces the effects of bactericidal agents
may enhance the adverse/toxic effect of rifampin
It may enhance the risk of adverse effects when combined with Cephalosporins
cefditoren might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
Action and SpectrumÂ
It works by killing the bacteria by attaching to the penicillin-binding proteins (PBPs) and preventing the cell wall formation. It is not affected by beta-lactamase enzyme, making it effective even against bacteria.Â
Frequency defined
1-10%
Vomiting (1%)
Dyspepsia (1-2%)
Abdominal pain (2%)
Nausea (4-6%)
Headache (2-3%)
<1%
difficile colitis
Increased bleeding time
Vaginal moniliasis
Hypersensitivity
Stevens-Johnson syndrome
Bacterial/fungal superinfection
>10%
Diarrhea (11-15%)
Blackbox warningÂ
NoneÂ
Contraindications/Cautions:Â
ContraindicationsÂ
Hypersensitivity reactionsÂ
CautionsÂ
Long term use of the drug might result in Carnitine DeficiencyÂ
Caution is necessary while breastfeedingÂ
Pregnancy warnings:   
Pregnancy category: B
Lactation: Excretion into human milk is unknown
Pregnancy Categories:     
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
PharmacologyÂ
Cephalosporin is a medication that is converted into an active form called cefditoren through a hydrolyzation in the body. Cephalosporin blocks bacteria from growing by binding it to certain proteins. Â
PharmacodynamicsÂ
It is effective against both gram negative and gram positive bacteria.Â
PharmacokineticsÂ
AbsorptionÂ
Bioavailability-14%Â
Absolute Bioavailability-16.1Â
DistributionÂ
Volume of distribution:9.3±6LÂ
MetabolismÂ
Plasma protein binding:0.05 to 10mg/mlÂ
Elimination/ExcretionÂ
More than 99% of the drug is excreted renally.Â
Elimination half life:1.6±0.4 hoursÂ
Administration:Â
It is administered orally along with the food for better absorptionÂ
Patient information leaflet:Â
Generic name: CefditorenÂ
Why do we use Cefditoren?Â
It belongs to the class of cephalosporins antibiotic to treat bacterial respiratory and skin infections.Â
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