Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
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Brand Name :
Tacef, Bestcall
Synonyms :
cefmenoxime
Class :
cephalosporins
Brand Name :
Tacef, Bestcall
Synonyms :
cefmenoxime
Class :
cephalosporins
Dosage forms and strengths Â
Susceptible infectionsÂ
Administer 1 to 4 grams a day by intramuscular or intravenous route by infusion/injection in 2 to 4 divided dosesÂ
The recommended maximum dose is 9 grams a day based on infection severityÂ
Dosage forms and strengths Â
Susceptible infectionsÂ
For child: Administer 40 to 80 mg/kg daily in 2 to 4 divided doses; based on the severity of infections, doses can be elevated Â
For neonates: Administer 40 to 80 mg/kg daily in 2 to 3 divided doses Â
Refer adult dosingÂ
it may diminish the excretion rate when combined with estradiol valerate resulting in a greater serum level
When cefmenoxime is used together with piroxicam, this leads to increased risk or seriousness of nephrotoxicity
When cefmenoxime is used together with proglumetacin, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with benoxaprofen, this leads to enhanced risk or seriousness of nephrotoxicity
cefmenoxime leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
cefmenoxime leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
cefmenoxime leads to a reduction in the rate of excretion of potassium perchlorate, which leads to an increased level of serum
cefmenoxime leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
When cefmenoxime is used together with difenpiramide, this leads to enhanced risk or seriousness of nephrotoxicity
cefmenoxime may decrease the excretion rate of almasilate, leading to higher serum levels
may increase the nephrotoxic effect
it may enhance the risk of nephrotoxicity when combined with phenylbutazone
When cefmenoxime is used together with antrafenine, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with atazanavir, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with bacitracin, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with balsalazide, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with benorilate, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with benoxaprofen, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with benzydamine, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with bumadizone, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with bumetanide, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with carprofen, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefaclor, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefadroxil, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefalotin, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefamandole, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefapirin, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefazolin, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefditoren, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefepime, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefmetazole, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefonicid, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefoperazone, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with ceforanide, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefotaxime, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefotetan, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefotiam, this leads to enhaced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefoxitin, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefpiramide, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefpirome, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefpodoxime, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefprozil, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefradine, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with ceftazidime, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with ceftibuten, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with ceftizoxime, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with ceftobiprole, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with ceftriaxone, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefuroxime, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with celecoxib, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cephalexin, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cephaloglycin, this leads to enhanced risk or seriousness of nephrotoxicity
choline magnesium trisalicylateÂ
When cefmenoxime is used together with choline magnesium trisalicylate, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cidofovir, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with colistimethate, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cyclosporine, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with dexibuprofen, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with dexketoprofen, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with diclofenac, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with diflunisal, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with etoricoxib, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with fenbufen, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmenoxime is used together with fenoprofen, this leads to enhanced risk or seriousness of nephrotoxicity
etoricoxib When etoricoxib is used together with proglumetacin, this leads to enhanced risk or seriousness of adverse events
cefmenoxime might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
Actions and Spectrum:Â
Action:Â
Bactericidal: cefmenoxime exerts its action by inhibiting the synthesis of the bacterial cell wall. It does this by binding to specific penicillin-binding proteins (PBPs) on the bacterial cell membrane, which are essential for cell wall formation. This disruption in cell wall synthesis ultimately leads to the lysis and death of susceptible bacteria. Â
Spectrum:Â
cefmenoxime demonstrates a broad spectrum of antibacterial effectiveness, making it productive against a diverse range of pathogens, including both gram-positive and gram-negative bacterial strains.Â
Frequency not defined Â
Hepatic dysfunctionÂ
CNS toxicityÂ
ConvulsionsÂ
NephrotoxicityÂ
Hypersensitivity reactionsÂ
DiarrhoeaÂ
VomitingÂ
NauseaÂ
Black Box Warning:Â Â Â
None
Contraindication/Caution:Â Â
Allergy: cefmenoxime should not be used in patients with a known hypersensitivity or allergy to cephalosporin antibiotics or any of the components of the drug. Â
Renal impairment: cefmenoxime’s main route of excretion is via the kidneys, which necessitates careful consideration when prescribing it to individuals with substantial renal dysfunction. It may be imperative to make dosage modifications to avert the accumulation of the medication and the associated risk of toxicity.Â
Gastrointestinal disease: Patients with a history of gastrointestinal diseases, particularly colitis, should be closely monitored while using cefmenoxime, as it can exacerbate these conditions.Â
Pregnancy and breast-feeding: cefmenoxime’s safety during pregnancy and breast-feeding is not well-established. It should only be used in these situations if the potential benefits outweigh the risks and under the supervision of a healthcare provider.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: cefmenoxime, a third-generation cephalosporin antibiotic, is a semi-synthetic drug employed to treat a range of bacterial infections.Â
Pharmacodynamics:Â Â
cefmenoxime, like other cephalosporin antibiotics, works by interfering with the bacterial cell wall building process, leading to its antibacterial effects. It does this by binding to and inhibiting the activity of penicillin-binding proteins (PBPs) located on the bacterial cell membrane. This interference weakens the cell wall, leading to cell lysis and bacterial death. cefmenoxime is bactericidal, meaning it kills bacteria rather than just inhibiting their growth. Â
Pharmacokinetics:Â
AbsorptionÂ
cefmenoxime is administered intravenously and intramuscularly. After injection, it is rapidly absorbed into the bloodstream.Â
DistributionÂ
It has good distribution throughout the body, including the lungs, skin, and soft tissues. cefmenoxime can penetrate the cerebrospinal fluid when the meninges are inflamed, making it useful for some central nervous system infections.Â
MetabolismÂ
cefmenoxime is not significantly metabolized in the body.Â
Excretion and EliminationÂ
The primary route of excretion for cefmenoxime is through the kidneys. Its primary route of elimination is through the urine without undergoing significant alteration. The elimination half-life can vary, but it is typically around 1 to 2 hours.Â
Administration: Â
A healthcare professional should administer it, as they will ensure the proper dosage and administration technique.Â
Patient information leafletÂ
Generic Name: cefmenoximeÂ
Why do we use cefmenoxime? Â
cefmenoxime can be prescribed to treat respiratory infections, including pneumonia, bronchitis, and lung abscesses caused by susceptible bacteria.Â
It is effective in treating skin and soft tissue infections like cellulitis, abscesses, and infected wounds.Â
cefmenoxime can be used to manage uncomplicated UTIs, including cystitis and pyelonephritis.Â
This antibiotic can be employed to treat intra-abdominal infections like peritonitis, appendicitis, and cholecystitis when caused by susceptible bacteria.Â
It can be employed to treat serious bloodstream infections caused by susceptible bacteria.Â
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