Brand Name :
humatin
Synonyms :
Cetenulin, monomycin A, paromomycin I
Class :
Anti-parasitic, Aminoglycoside
Dosage Forms & Strengths
capsule
250mg
25 - 35
mg/kg/day
Orally
every 6 hours
5 - 10
days
Capsule
4
g
Orally
every day
5 - 6
days
Capsule
20 - 30
mg/kg
Orally
every 8 hrs
Capsule
Dosage Forms & Strengths
capsule
250mg
25-35mg/kg/day every 8 hours orally for seven days
Or
750mg/m2/day every 6 hours orally for five days
25 - 35
mg/kg
Orally
every 8 hrs
5 - 10
days
25 - 35
mg/kg
Orally
every 8 hrs
5 - 10
days
25 - 35
mg/kg
Orally
every 8 hrs
5 - 10
days
20 - 30
mg/kg
Orally
every 8 hours
Capsule
may decrease the therapeutic effect of antibiotics
may increase the nephrotoxic effect of aminoglycosides
may decrease the therapeutic effect of antibiotics
may increase the toxic effect of aminoglycosides
may decrease the therapeutic effect of antibiotics
may increase the nephrotoxic effect
may increase the nephrotoxic effect
may increase the neuromuscular-blocking effect
may increase the nephrotoxic effect
may diminish the serum concentration of pencillins
may diminish the serum concentration of pencillins
may diminish the serum concentration of pencillins
may diminish the serum concentration of pencillins
may diminish the serum concentration of pencillins
may increase the nephrotoxic effect
may increase the hypo calcaemic effect
may increase the hypo calcaemic effect
may increase the hypo calcaemic effect
may increase the hypo calcaemic effect
may increase the hypo calcaemic effect
may increase the neuromuscular-blocking effect
may increase the nephrotoxic effect
may increase the nephrotoxic effect
may increase the nephrotoxic effect
may increase the nephrotoxic effect
may increase the nephrotoxic effect
may increase the ototoxic effect
may increase the therapeutic effect of antibiotics
may increase the therapeutic effect of antibiotics
may increase the therapeutic effect of antibiotics
may increase the therapeutic effect of antibiotics
may increase the therapeutic effect of antibiotics
It may enhance the serum concentration when combined with CYP3A4 Substrates
It may enhance the serum concentration when combined with CYP3A4 Substrates
It may enhance the serum concentration when combined with CYP3A4 Substrates
It may enhance the serum concentration when combined with CYP3A4 Substrates
It may enhance the serum concentration when combined with CYP3A4 Substrates
it interacts with meclizine through an unspecified mechanism of interaction
Frequency defined:
1-10%
Abdominal cramps
Vomiting
Diarrhea
Nausea
Heartburn
<1%
Vertigo
Rash
Steatorrhea
Eosinophilia
Headache
Exanthema
Pruritis
Secondary enterocolitis
Ototoxicity
Pregnancy consideration:
US FDA pregnancy category: C
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Patient information leaflet
Generic Name: paromomycin
Pronounced: [ PAR-oh-moe-MYE-sin]
Why do we use paromomycin?
It is used in the treatment of acute and chronic intestinal amebiasis and acts as a supplement in hepatic coma