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Brand Name :
N/A
Synonyms :
cefpiramide
Class :
Third generation cephalosporins
Brand Name :
N/A
Synonyms :
cefpiramide
Class :
Third generation cephalosporins
Dosage Forms & Strengths
Injectable solution
10g
2g
1g
1 to 2 g is given as cefpiramide sodium through Intravenous infusion in two divided doses
Safety and efficacy were not established
Refer to the adult dosing regimen
may increase the nephrotoxic effect of cephalosporins
neomycin/polymyxin B/bacitracin topical
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
it may diminish the excretion rate when combined with estradiol valerate resulting in a greater serum level
It may enhance the risk of adverse effects when combined with Barbiturates
It may enhance the risk of adverse effects when combined with Barbiturates
It may enhance the risk of adverse effects when combined with Barbiturates
It may enhance the risk of adverse effects when combined with Barbiturates
It may enhance the risk of adverse effects when combined with Barbiturates
When cefpiramide is used together with piroxicam, this leads to increased risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefpiramide, this leads to enhanced risk or seriousness of nephrotoxicity
When cefpiramide is used together with proglumetacin, this leads to enhanced risk or seriousness of nephrotoxicity
When cefpiramide is used together with benoxaprofen, this leads to enhanced risk or seriousness of nephrotoxicity
cefpiramide leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
cefpiramide leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
cefpiramide leads to a reduction in the rate of excretion of potassium acetate, which leads to an increased level of serum
cefpiramide leads to a reduction in the rate of excretion of potassium perchlorate, which leads to an increased level of serum
cefpiramide leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
When cefpiramide is used together with difenpiramide, this leads to enhanced risk or seriousness of nephrotoxicity
cefpiramide: it may decrease the excretion rate of isepamicin
may increase the anticoagulant effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
cefpiramide might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
Actions and spectrum:
It belongs to the class of cephalosporin antibiotic, which targets the proteins that are involved in cell wall construction in bacteria. Penicillin-binding proteins (PBPs) are useful for synthesizing bacterial cell wall which specifically stops the activity. It achieves this by disrupting the linkage between peptidoglycan chains, which are the structural units of bacterial cell walls. It is effective both gram positive and gram negative bacteria.
Frequency not defined
urticaria
joint pain
Angioedema
haemolytic anaemia
neutropaenia
convulsions
Nausea
fever
rashes
interstitial nephritis
thrombocytopaenia
diarrhoea
Vomiting
Pseudomembranous colitis
Black Box Warning:
None
Contraindication/Caution:
Contraindication:
Human Immunodeficiency virus
Hypersensitivity
Infectious Mononucleosis
Caution:
Caution is needed with poor renal function.
Pregnancy consideration: pregnancy category: not assigned
Lactation: excreted into human milk: unknown
Pregnancy category:
Pharmacology
It is a cephalosporin antibiotic, targets proteins that bind penicillin, weakening bacterial cell walls. It is administered intravenously as a solution. It’s effectiveness can be affected by bacterial resistance and patient factors like kidney function and potential allergies.
Pharmacodynamics
Due to interference with cell wall production by cefpiramide, bacteria develop cell walls with reduced structural integrity. This leads to increase in the permeability, disruption of osmotic balance, cell lysis, and ultimately the bacterial death.
Pharmacokinetics
Limited data available
Administration
It is administered intravenously by infusion or injection.
Patient information leaflet:
Generic Name: cefpiramide
Why do we use cefpiramide?
It is a medication used to treat bacterial infections affecting the respiratory system and urinary system.
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