Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Celecoxib
Synonyms :
celecoxib
Class :
Anti-inflammatory drugs and non-Selective COX inhibitors 
Brand Name :
Celecoxib
Synonyms :
celecoxib
Class :
Anti-inflammatory drugs and non-Selective COX inhibitors 
Dosage Forms & Strengths Â
Tablets  Â
10 mg Â
20 mg Â
200
mg
Orally 
once a day
200
mg
Orally 
twice a day
400
mg
Orally 
once a day
120
mg
Orally 
once a day
200
mg
Orally 
once a day
200
mg
Orally 
twice a day
may increase the anticoagulation effect when combined
increases toxicities such as myelosuppression, renal toxicity, and GI toxicity
increases toxicities such as myelosuppression, renal toxicity, and GI toxicity
CYP2C9 enhancers may decrease the the bioavailability of celecoxib 
may enhance the risk of adverse effects when combined with celecoxib
the toxicity of either of the drugs is increased due to pharmacokinetic synergism
it may diminish the metabolism when combined with azelastine
may increase the anticoagulation when combined with ginkgo biloba
Combining celecoxib with pranlukast may cause a reduction in the celecoxib’s metabolism
celecoxib has the potential to reduce the rate of excretion of idebenone, leading to an elevation in levels of serum
When loracarbef is used together with celecoxib, the risk or seriousness of nephrotoxicity is enhanced
When celecoxib is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When domeperidone and celecoxib is used together, this leads to reduction in the domeperidone’s metabolism
When celecoxib is used together with piroxicam, this leads to enhanced risk or seriousness of adverse outcomes
When encainide is used together with celecoxib, this leads to a reduction in the encainide’s metabolism
When melitracen is used together with celecoxib, this leads to increased risk or seriousness of gastrointestinal bleeding
When celecoxib is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When cefmenoxime is used together with celecoxib, this leads to enhanced risk or seriousness of nephrotoxicity
When celecoxib is used together with proglumetacin, this leads to enhanced risk or seriousness of adverse events
When celecoxib is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
celecoxib leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
celecoxib leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
When indisulam is used together with celecoxib, this leads to a reduction in celecoxib metabolism
When celecoxib is used together with nifenazone, this leads to enhanced risk or seriousness of adverse events
celecoxib: it may increase the risk or severity of hypertension with procaterol
celecoxib: it may increase the risk of hyperkalemia with caroverine
celecoxib: it may decrease activities of antihypertensive drugs
celecoxib: it may decrease activities of antihypertensive drugs
celecoxib: it may decrease activities of antihypertensive drugs
celecoxib: it may decrease activities of antihypertensive drugs
celecoxib: it may decrease activities of antihypertensive drugs
celecoxib may decrease the excretion rate of almasilate, leading to higher serum levels
When celecoxib is used together with diazoxide, this leads to reduction in therapeutic effectiveness of diazoxide
it increases the nephrotoxicity of cephalosporins
may enhance the serum concentration of CYP2C9 inhibitors
may increase the risk or severity of hypertension when combined
may enhance the risk or severity of gastrointestinal irritation when combined with celecoxib
the toxicity of either of the drugs is increased due to pharmacokinetic synergism
the serum levels of potassium may be increased
When celecoxib is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
the risk of bleeding may be increased
celecoxib might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
Actions and Spectrum: 
Celecoxib is a selective COX-2 inhibitor which is an NSAID used in the treatment of arthritis by blocking the synthesis of prostaglandins from the arachidonic acid. Prostaglandins are also involved in the inflammatory responses and the sensation of pain. Because it selectively blocks COX-2, celecoxib decreases the synthesis of these inflammatory prostaglandins but does not affect the action of COX-1, which generates the protective gastric prostaglandins. Â
Nausea Â
High Blood pressure Â
Back pain Â
Depression Â
Flatulence Â
Diarrhea Â
Sinus inflammation Â
Abdominal pain Â
anemia Â
Blackbox Warning Â
Celecoxib like all NSAIDs has the FDA boxed warning of increased cardiovascular risk including heart attack and stroke. Unlike celecoxib which is a selective COX-2 inhibitor it can come under much the same controversy as rofecoxib which was withdrawn from the market in 2004. In the reviews, the cardiovascular risk of celecoxib appears to be inconclusive and comparable in some trials to ibuprofen and naproxen trials. Â
Contraindications/Cautions Â
Hypersensitivity Â
Congestive Heart Failure Â
Hypertension Â
Pregnancy/Lactation Â
Pregnancy consideration:  Pregnancy category- C Â
Lactation: Excretion of celecoxib in breast milk is not known. Â
Pregnancy category: Â
Pharmacology Â
Celecoxib selectively blocks the cyclooxygenase-2 enzyme and thus inhibits the prostaglandins synthesis that cause inflammation, pain and fever. Preserving COX-1 activity allows for the formation of prostaglandins which is involved in protection of mucosa and platelet aggregation. Â
Pharmacodynamics Â
It selectively inhibits the COX-2 enzyme which is helpful in lowering the fever, inflammation, and discomfort.  Â
Pharmacokinetics Â
Absorption Â
Bioavailability: Undetermined Â
Peak Plasma Time: ≤ 3 hour (capsule form) and ≤ 1 hour (oral solution form) Â
Peak Plasma Concentration: 705 ng/mL Â
Distribution Â
Protein Binding: 97% which binds mainly to albumin and to a lesser extent to alpha1-acid glycoprotein. Â
Volume of Distribution shows 400L Â
Metabolism Â
Metabolized: In the liver by the help of CYP2C9 Â
Metabolites: Glucuronide of SC-62807 Â
Enzymes Inhibited: COX-2 Â
Elimination Â
Half-life: 11 hours (Moderate), 13. 1 hour (chronic renal insufficiency) or 1 hour with moderate hepatic impairment Â
Dialyzable: Undetermined Â
Clearance: 500 mL/min Â
Excretion: 57% in feces and 27% in urine Â
Administration Â
Celecoxib is an orally taken drug available in capsules, topical solutions and customized for the topical route with/without iontophoresis. The dosing ranges from 50 to 400 mg. Â
Patient information leaflet Â
Generic Name: celecoxib Â
Pronounced: cele-coks-ib Â
Why do we use celecoxib? Â
Celecoxib is a pain reliever and ant-inflammation drug that inhibits COX-2 enzymes (a key component in producing prostaglandins). It is commonly prescribed for conditions like arthritis, ankylosing spondylitis, menstrual pain, juvenile rheumatoid arthritis in children and managing colon hereditary polyps. Â
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
