ritodrine

medtigo

ritodrine

Brand Name :

Yutopar

Synonyms :

ritodrine

Class :

Adrenergic Beta Agonists

Action and Spectrum

Mechanism of action

Its mechanism of action stimulates beta-2 adrenergic receptors in the uterus, which leads to smooth muscle relaxation, including the smooth muscle of the uterus

The relaxation of the uterine smooth muscle can help prevent contractions and delay the onset of labor. ritodrine also has a bronchodilator effect, which can help relieve respiratory distress in premature infants

Spectrum

The spectrum of activity of ritodrine is limited to its use in preventing premature labor. It is ineffective in treating labor that has already started or inducing labor in women at term. Ritodrine may be used alone or with other medications to help delay labor in high-risk pregnancies

Dosing & Uses

Drug Interaction

Adverse Reaction

Adverse Reaction:

Tachycardia (rapid heart rate)

Tremors

Headache

Nausea

Hypotension (low blood pressure)

Hyperglycemia (high blood sugar)

Pulmonary edema (fluid accumulation in the lungs)

Hypokalemia (low potassium levels)

Black Box Warning

Contraindication / Caution

Contraindications

Hypersensitivity: Hypersensitivity to the medication or any of its components. This can cause an allergic reaction and can be life-threatening
Cardiac disease: It can cause cardiovascular side effects, such as tachycardia, arrhythmias, and hypotension, which can be dangerous for patients with pre-existing cardiac disease
Pulmonary disease: It can cause respiratory distress, bronchospasm, and other pulmonary side effects, which can be dangerous for patients with underlying respiratory disease
Hypertension: It can cause an increase in blood pressure, which can be dangerous for patients with hypertension
Diabetes: It can cause hypoglycemia, which can be dangerous for patients with diabetes
Hyperthyroidism: It can exacerbate hyperthyroidism, which can cause cardiovascular and other adverse effects
Multiple gestations: It may be less effective in preventing preterm labor in patients with multiple gestations (e.g., twins, triplets).

Caution

Cardiovascular side effects: It can cause cardiovascular side effects, such as increased heart rate, palpitations, and chest pain. This is because ritodrine acts as a beta-agonist, which can stimulate the sympathetic nervous system and cause an increase in heart rate and blood pressure.
Pulmonary edema: It can cause pulmonary edema, which is a buildup of fluid in the lungs. This can cause shortness of breath, coughing, and difficulty breathing. Patients with a history of pulmonary disease or asthma should be closely monitored when taking ritodrine
Hypoglycemia: ritodrine can cause hypoglycemia, a low blood sugar level. This can cause sweating, dizziness, and confusion
Hyperglycemia: ritodrine can also cause hyperglycemia, which is a high blood sugar level. This can cause symptoms such as thirst, frequent urination, and blurred vision

Pregnancy / Lactation

Pregnancy consideration: Insufficient data available

Lactation: Excretion of the drug in human breast milk is unknown

Pregnancy category:

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology

ritodrine is a medication classified as a beta-agonist, specifically a beta-2 selective agonist. It works by binding to beta-2 receptors in the smooth muscle of the uterus, causing relaxation of the uterus and delaying premature labor

Pharmacodynamics

In sympathetic neuroeffector junctions of several organs, including the uterus, beta-2 adrenergic receptors can be found. It is an agonist of beta-2 receptors. It activates the beta-2 adrenergic receptor, boosts cAMP, and lowers the amount of intracellular calcium. Premature uterine contractions are reduced as a result of the relaxing of the uterine smooth muscle caused by the drop in calcium concentration

Pharmacokinetics

Absorption

It can be administered via intravenous injection or oral tablet. When administered orally, ritodrine is rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations reached within 30-60 minutes.

Distribution

It is distributed throughout the body, including crossing the placenta and entering breast milk. The volume of distribution is relatively small, indicating that it remains primarily in the plasma

Metabolism

It is metabolized by the liver, primarily by the enzyme cytochrome P450 3A4, to form inactive metabolites that are excreted in the urine

Elimination/Excretion

The elimination half-life of ritodrine is about 3-4 hours. It is excreted mainly in the urine, with a small portion also eliminated in the feces

Adminstartion

Administration

ritodrine is a medication used to delay premature labor. It can be administered by intravenous injection or oral tablet. Here are some details about the administration of ritodrine:

Intravenous injection: When ritodrine is administered by intravenous injection, it is typically given as a continuous infusion. The initial dose of ritodrine is usually 50-100 mcg/min, gradually increasing until contractions are effectively suppressed, or the maximum recommended dose of 400 mcg/min is reached. The infusion rate is usually titrated based on the patient’s response and any potential side effects. Intravenous ritodrine is typically administered in a hospital setting under close monitoring

Oral tablet: ritodrine is available as an oral tablet in some countries but not in others. The recommended oral dose of ritodrine is usually 10-20 mg every 3-4 hours. The dose may be adjusted based on the patient’s response and any potential side effects

Patient Information Leaflet

Patient information leaflet

Generic Name: ritodrine

Why do we use ritodrine?

ritodrine is a medication primarily used to delay premature labor. It works by relaxing the uterus muscles, which can help stop or slow down contractions.

Here are some of the specific uses of ritodrine:

Delaying premature labor: ritodrine is used to delay premature labor in women at risk of delivering their babies too early. It is often used as a short-term treatment to give time for corticosteroids, which can help improve the baby’s lung function if it is born prematurely
Tocolytic therapy: ritodrine is also used as part of tocolytic therapy, a treatment to stop preterm labor contractions. Other medications may be combined with ritodrine to provide more effective tocolytic therapy

ritodrine

No data available for drug.

DRUG INTERACTION

ritodrine

&

ritodrine +

Contraindicated

Serious Use Alternative

Monitor Closely

Minor

ritodrine

No data available for drug.

DRUG INTERACTION

ritodrine

&

ritodrine +

Contraindicated

Serious Use Alternative

Monitor Closely

Minor

medtigo

ritodrine

Brand Name :

Synonyms :

Class :

Action and Spectrum

Dosing & Uses

Drug Interaction

Adverse Reaction

Black Box Warning

Contraindication / Caution

Pregnancy / Lactation

Pharmacology

Adminstartion

Patient Information Leaflet

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