A Framework for Fitness-for-Purpose and Reuse in Computational Phenotyping
November 17, 2025
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Brand Name :
Marezine, Cyclivert, Bonine for Kids
Synonyms :
cyclizine
Class :
Antiemetics, Antihistamines
Brand Name :
Marezine, Cyclivert, Bonine for Kids
Synonyms :
cyclizine
Class :
Antiemetics, Antihistamines
Dosage Forms & StrengthsÂ
TabletÂ
25 mgÂ
50 mgÂ
Dosage Forms & StrengthsÂ
Tablet (chewable)Â
25 mgÂ
TabletÂ
25 mgÂ
50 mgÂ
Refer to adult dosingÂ
it increases the effect of ototoxicity of aminoglycosides Immune Checkpoint Inhibitors
it increases the effect of ototoxicity of aminoglycosides Immune Checkpoint Inhibitors
it increases the effect of ototoxicity of aminoglycosides Immune Checkpoint Inhibitors
The potential for increased CNS depression risk or seriousness occurs when cyclizine is used together with pinazepam
when ajmaline is used together with cyclizine, the risk or seriousness of QTc prolongation is enhanced
The potential for increased CNS depression risk or seriousness occurs when cyclizine is used together with pipecuronium
When cyclizine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
The potential for CNS depression may enhanced when cyclizine is used together with fencamfamin
When cyclizine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When cyclizine is used together with levosulpiride, the risk or seriousness of CNS depression is enhanced
When chlordiazepoxide is used together with cyclizine, this leads to enhanced risk or seriousness of CNS depression
When acetohexamide is used together with cyclizine, this lead to reduction in acetohexamide’s metabolism
When ponesimod is used together with cyclizine, this leads to enhanced risk or seriousness of bradycardia
When cyclizine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When cyclizine is used together with givinostat, this leads to enhanced risk or seriousness of Qtc prolongation
When emylcamate is used together with cyclizine, this leads to enhanced risk or seriousness of CNS depression
When acepromazine is used together with cyclizine, this leads to enhanced risk or seriousness of CNS depression
when combined, it may increase sedation
when combined, it may increase sedation
may increase the ototoxic effect
Actions and SpectrumÂ
cyclizine works by inhibiting the effects of histamine, a substance the body releases during allergic reactions. It lowers histamine activity in the body by inhibiting histamine receptors. The spectrum of cyclizine refers to the range of conditions for which it is indicated.
Frequency defined Â
1-10%Â
DiplopiaÂ
PolyuriaÂ
NauseaÂ
Urinary retentionÂ
HeadacheÂ
DermatitisÂ
>10%Â
XerostomiaÂ
DrowsinessÂ
Black Box WarningÂ
None
Contraindication/Caution:Â
Contraindication:Â
Caution:Â
Pregnancy consideration:    Â
Pregnancy category: BÂ
Lactation: Excretion into human milk is unknown Â
Pregnancy Categories:        Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.Â
Category N: There is no data available for the drug under this category.Â
Pharmacology Â
The neurotransmitter acetylcholine, which is involved in several body functions, is inhibited by cyclizine, giving it additional anticholinergic characteristics. Â
PharmacodynamicsÂ
cyclizine having sedative properties and can cause CNS depression. It acts as a depressant on the CNS, leading to drowsiness and a calming effect. Â
PharmacokineticsÂ
Absorption  Â
cyclizine is well absorbed orally after administration. It undergoes first-pass metabolism in the liver. Â
DistributionÂ
cyclizine is widely distributed throughout the body. Â
MetabolismÂ
cyclizine undergoes extensive metabolism in the liver different metabolic pathways. Â
Elimination and excretionÂ
cyclizine and its metabolites are excreted in the urine.
AdministrationÂ
cyclizine is administered orally in the form of tablets or capsules.Â
Patient information leafletÂ
Generic Name: cyclizine Â
Why do we use cyclizine?Â
cyclizine prevents and alleviates motion sickness symptoms, including nausea, vomiting, and dizziness.   Â
cyclizine is used to treat nausea and vomiting with post-operative recovery, vertigo and migraines. Â
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