Impact of Maternal Eating Disorders on Pediatric Respiratory Health in Europe
December 10, 2025
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Brand Name :
Marezine, Cyclivert, Bonine for Kids
Synonyms :
cyclizine
Class :
Antiemetics, Antihistamines
Brand Name :
Marezine, Cyclivert, Bonine for Kids
Synonyms :
cyclizine
Class :
Antiemetics, Antihistamines
Dosage Forms & Strengths
Tablet
25 mg
50 mg
Dosage Forms & Strengths
Tablet (chewable)
25 mg
Tablet
25 mg
50 mg
Refer to adult dosing
it increases the effect of ototoxicity of aminoglycosides Immune Checkpoint Inhibitors
it increases the effect of ototoxicity of aminoglycosides Immune Checkpoint Inhibitors
it increases the effect of ototoxicity of aminoglycosides Immune Checkpoint Inhibitors
The potential for increased CNS depression risk or seriousness occurs when cyclizine is used together with pinazepam
when ajmaline is used together with cyclizine, the risk or seriousness of QTc prolongation is enhanced
The potential for increased CNS depression risk or seriousness occurs when cyclizine is used together with pipecuronium
When cyclizine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
The potential for CNS depression may enhanced when cyclizine is used together with fencamfamin
When cyclizine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When cyclizine is used together with levosulpiride, the risk or seriousness of CNS depression is enhanced
When chlordiazepoxide is used together with cyclizine, this leads to enhanced risk or seriousness of CNS depression
When acetohexamide is used together with cyclizine, this lead to reduction in acetohexamide’s metabolism
When ponesimod is used together with cyclizine, this leads to enhanced risk or seriousness of bradycardia
When cyclizine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When cyclizine is used together with givinostat, this leads to enhanced risk or seriousness of Qtc prolongation
When emylcamate is used together with cyclizine, this leads to enhanced risk or seriousness of CNS depression
When acepromazine is used together with cyclizine, this leads to enhanced risk or seriousness of CNS depression
when combined, it may increase sedation
when combined, it may increase sedation
may increase the ototoxic effect
Actions and Spectrum
cyclizine works by inhibiting the effects of histamine, a substance the body releases during allergic reactions. It lowers histamine activity in the body by inhibiting histamine receptors. The spectrum of cyclizine refers to the range of conditions for which it is indicated.
Frequency defined
1-10%
Diplopia
Polyuria
Nausea
Urinary retention
Headache
Dermatitis
>10%
Xerostomia
Drowsiness
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: B
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
The neurotransmitter acetylcholine, which is involved in several body functions, is inhibited by cyclizine, giving it additional anticholinergic characteristics.
Pharmacodynamics
cyclizine having sedative properties and can cause CNS depression. It acts as a depressant on the CNS, leading to drowsiness and a calming effect.
Pharmacokinetics
Absorption
cyclizine is well absorbed orally after administration. It undergoes first-pass metabolism in the liver.
Distribution
cyclizine is widely distributed throughout the body.
Metabolism
cyclizine undergoes extensive metabolism in the liver different metabolic pathways.
Elimination and excretion
cyclizine and its metabolites are excreted in the urine.
Administration
cyclizine is administered orally in the form of tablets or capsules.
Patient information leaflet
Generic Name: cyclizine
Why do we use cyclizine?
cyclizine prevents and alleviates motion sickness symptoms, including nausea, vomiting, and dizziness.
cyclizine is used to treat nausea and vomiting with post-operative recovery, vertigo and migraines.
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