Genomic Study Maps Shared Risk Factors for 14 Psychiatric Disorders
December 14, 2025
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Brand Name :
Jadenu Sprinkle, Exjade, Jadenu
Synonyms :
deferasirox
Class :
Chelators
Brand Name :
Jadenu Sprinkle, Exjade, Jadenu
Synonyms :
deferasirox
Class :
Chelators
Dosage Forms & Strengths
Tablet oral (Jadenu)
90 mg
180 mg
360 mg
Granules oral (Jaden sprinkle)
90 mg
180 mg
360 mg
Oral suspension tablet (Exjade)
125 mg
250 mg
500 mg
Dosage Forms & Strengths
Tablet oral (Jadenu)
90 mg
180 mg
360 mg
Granules oral (Jaden sprinkle)
90 mg
180 mg
360 mg
Oral suspension tablet (Exjade)
125 mg
250 mg
500 mg
Refer to adult dosing
It may diminish the serum concentration when combined with bile acid sequestrants
rifampin: they may diminish the serum concentration of deferasirox
may increase GI bleeding, ulceration and irritation
may increase GI bleeding, ulceration and irritation
may increase GI bleeding, ulceration and irritation
may increase GI bleeding, ulceration and irritation
may increase GI bleeding, ulceration and irritation
bisphosphonate derivatives increase the toxicity of deferasirox
bisphosphonate derivatives increase the toxicity of deferasirox
bisphosphonate derivatives increase the toxicity of deferasirox
bisphosphonate derivatives increase the toxicity of deferasirox
may decrease the absorption of iron preparations
may decrease the absorption of iron preparations
may decrease the absorption of iron preparations
may decrease the absorption of iron preparations
may decrease the absorption of iron preparations
may have an increasingly adverse effect when combined with deferasirox
may have an increasingly adverse effect when combined with deferasirox
may have an increasingly adverse effect when combined with deferasirox
may have an increasingly adverse effect when combined with deferasirox
may have an increasingly adverse effect when combined with deferasirox
may have an increasingly adverse effect when combined with deferasirox
may have an increasingly adverse effect when combined with deferasirox
may have an increasingly adverse effect when combined with deferasirox
may have an increasingly adverse effect when combined with deferasirox
may have an increasingly adverse effect when combined with deferasirox
It may enhance the effect when combined with beclomethasone, inhaled by immunosuppressive effects
may have an increasingly adverse effect when combined with deferasirox
may have an increasingly adverse effect when combined with deferasirox
may have an increasingly adverse effect when combined with deferasirox
may have an increasingly adverse effect when combined with deferasirox
may have an increasingly adverse effect when combined with deferasirox
It may increase the toxic effect when combined with Bisphosphonate Derivatives
It may increase the toxic effect when combined with Bisphosphonate Derivatives
It may increase the toxic effect when combined with Bisphosphonate Derivatives
It may increase the toxic effect when combined with Bisphosphonate Derivatives
It may increase the toxic effect when combined with Bisphosphonate Derivatives
When deferasirox is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When deferasirox is used together with adenine, this leads to a reduction in the deferasirox's metabolism
deferasirox: it may enhance the toxic effect of Anti-Inflammatory Agents
deferasirox: it may enhance the toxic effect of Anti-Inflammatory Agents
aspirin, chlorpheniramine, and phenylephrine
deferasirox: it may enhance the toxic effect of Anti-Inflammatory Agents
deferasirox: it may enhance the toxic effect of Anti-Inflammatory Agents
deferasirox: it may enhance the toxic effect of Anti-Inflammatory Agents
deferasirox: it may decrease the therapeutic efficacy of etynodiol
deferasirox: it may decrease the metabolism of cerivastatin
it decreases the concentration of CYP3A4 substrates in serum
may diminish the serum concentration of CYP3A4 Substrates
When deferasirox is used together with lomitapide, this leads to an enhancement in lomitapide’s metabolism
When deferasirox is aided by hesperetin, it elevates concentration serum of hesperetin
Actions and Spectrum:
deferasirox works by creating iron-based stable complexes that are then expelled from the body. deferasirox creates a compound with iron in a 2:1 ratio, which the body subsequently excretes through faeces and urine.
deferasirox’s main area of therapeutic action is the treatment of chronic iron excess. For acute iron toxicity or iron deficient anaemia, it is ineffective.
Frequency Defined
>10%
Nausea (11-23%)
Influenza (11%)
Vomiting (10-21%)
Rash (8-11%)
Cough (14%)
Nasopharyngitis (13%)
Pharyngolaryngeal pain (11%)
Pyrexia (19%)
Headache (16%)
<1%
Anaphylaxis
Cytopenias, including neutropenia, agranulocytosis and thrombocytopenia; leukocytoclastic vasculitis
Angioedema
Post marketing reports
Immune system disorders: Hypersensitivity reactions (including anaphylaxis and angioedema)
Gastrointestinal disorders: GI perforation and hemorrhage
Endocrine: Hypokalemia
1-10%
ALT increased (2-8%)
Arthralgia, back pain (6-7%)
Rhinitis (6%)
Transaminitis (4%)
Urticaria (4%)
Fatigue (6%)
Ear infection (5%)
Acute tonsillitis (6%)
Respiratory tract infection (10%)
Bronchitis (9%)
Black Box Warning
Renal and hepatic failure.
Contraindication/Caution:
It is contraindicated for those with a Hx of medication or component hypersensitivity, and liver/kidney impairment.
Pregnancy warnings:
Pregnancy category: N/A
Lactation: Excreted into human milk is unknown
Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology
Pharmacodynamics
It involves interaction with iron ions creating a stable complex that can be eliminated through urine and feces. Its effects can be monitored by measuring serum ferritin levels.
Pharmacokinetics
Absorption
It is more readily absorbed
Distribution
Protein-bound is dispersed throughout the plasma 99%.
Metabolism
It is metabolized deferasirox is glucuronidation.
Elimination and excretion
It is excreted by feces (84%) and urine (8%).
Administration:
It is orally given one daily with/without meals.
Patient information leaflet
Generic Name: deferasirox
Why do we use deferasirox?
Deferasirox helps in treating sickle cell disease, thalassemia, and chronic anemias due to chronic iron excess caused by frequent blood transfusions which can cause organ damage and malfunction.
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