diatrizoic acid

Action and Spectrum

Actions and Spectrum: 

Actions: 

Diatrizoic acid’s main effects are associated with its ability to enhance contrast in diagnostic imaging. It helps to make anatomical structures and body parts more visible rather than having a therapeutic impact in the traditional sense. The kind of imaging investigation and the medical background of each patient determine the form of diatrizoic acid—ionic or nonionic—to use. Because of this, medical professionals may now base their judgments about therapy and diagnosis on clear, complete diagnostic images. 

Spectrum: 

diatrizoic acid is widely used in diagnostic radiology for a variety of purposes, such as Upper Gastrointestinal series, Barium enemas, Angiography, Urography, and Gastrointestinal imaging, among others.

Drug Interaction

Adverse Reaction

Frequency not defined 

Anaphylaxis 

Contrast induced nephropathy 

Hypothyroidism 

Hyperthyroidism 

GIT discomfort 

Mild changes in heart rate or blood pressure 

Local injection site reactions-pain, redness 

Black Box Warning

Black Box Warning: 

Prior to performing a diatrizoic acid procedure, patients should inform their healthcare professionals of any allergies, ailments, or concerns. 

Contraindication / Caution

Contraindication/Caution: 

Contraindications 

• Hypersensitivity 
• Severe renal impairment 
• Heart failure 
• Uncontrolled diabetes 
• HTN 
• Thyroid disorders 
• Pregnancy 
• Breast feeding 

Cautions 

• Severe renal impairment 
• Heart failure 
• Uncontrolled diabetes 
• HTN 
• Thyroid disorders 
• Pregnancy 
• Breast feeding 

Pregnancy / Lactation

Pregnancy consideration:  

No data is available regarding the administration of the drug during pregnancy. 

Breastfeeding warnings:  

No data is available regarding the excretion of drug in breast milk. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology: 

The main areas of study in the pharmacology of diatrizoic acid’s  are its radiopaque characteristics and how it behaves in the body during imaging procedures. It is essential for improving the view of anatomical features and areas of interest, which helps with the diagnosis and treatment of a number of diseases. The type of imaging study and the medical history of each patient will determine the best form and dosage of diatrizoic acid. In a clinical context, always employ contrast agents according to medical specialists’ instructions. 

Pharmacodynamics: 

diatrizoic acid’s primary pharmacodynamic effect is contrast enhancement. It makes blood arteries, organs, and other structures more visible, making it possible for medical professionals to acquire precise and comprehensive diagnostic pictures. 

Pharmacokinetics: 

Absorption 

The mode of administration for diatrizoic acid can vary based on the imaging process, such as oral or intravenous. It is absorbed by the gastrointestinal tract when administered orally. It is quickly disseminated throughout the bloodstream when given intravenously. 

Distribution 

Following intravenous delivery, diatrizoic acid is dispersed throughout the body through the circulatory system. It gets to the intended organs or tissues that medical imaging needs to see. The distribution is determined by the areas of interest and the particular imaging technique. 

Metabolism 

The body does not metabolize diatrizoic acid very much. Depending on whether an ionic or non-ionic form is utilized, it is mainly eliminated either unaltered or as conjugated metabolites. 

Elimination and Excretion 

Renal excretion is the main method by which diatrizoic acid is removed from the body. It is eliminated in the urine after being filtered by the kidneys’ glomeruli. Depending on the type of diatrizoic acid and the particular imaging technique, the elimination half-life may change. 

The particular type of diatrizoic acid used, renal function, and patient characteristics can all have an impact on how quickly the drug is removed from the body. 

Adminstartion

Administration: 

Following sterile catheterization, the bladder should be filled to capacity using the appropriate sterile administration set; do not use excessive pressure; the bladder is typically full when there is discomfort or reflux in the bladder or when spontaneous urination occurs.

For vascular examinations, diatrizoic acid is injected, and for gastrointestinal imaging, it can be taken orally. The individual diagnostic process and needs determine the route of administration to be used. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: diatrizoic acid 

Pronounced: Dye-a-TRIZ-oh-ik AS-id 

Why do we use diatrizoic acid? 

During medical imaging techniques, diatrizoic acid is utilized as a radiopaque contrast agent. It is used to improve the visibility of particular body parts on diagnostic radiography examinations.