The Navigation Model of Therapy: Why Awareness Changes Everything
November 16, 2025
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Brand Name :
Videx
Synonyms :
didanosine
Class :
Antiviral agents and Anti-HIV (antiretroviral)
Brand Name :
Videx
Synonyms :
didanosine
Class :
Antiviral agents and Anti-HIV (antiretroviral)
Dosage Forms & Strengths
Capsule delayed release, Oral:
200 mg
125 mg
250 mg
400 mg
Solution reconstituted, Oral:
2g
4g
Note: Didanosine is not recommended as an initial line of therapy for the treatment of HIV anymore.
For <60 kg:
125
mg
Solution
oral
twice a day
or 250 mg oral solution once a day
>60 kg: 200 mg oral solution twice a day or 400 mg oral solution once a day
25 kg to 60 kg: 250 mg oral capsule once daily
Dosage Forms & Strengths
Capsule delayed release, Oral:
200 mg
125 mg
250 mg
400 mg
Solution reconstituted, Oral:
2g
4g
Note: Didanosine is not recommended as an initial line of therapy for the treatment of HIV anymore.
For 20 kg to <25kg:
200
mg/day
Capsule
Oral
For 25 kg to <60 kg: 250mg/day oral capsule
For >60 kg: 400 mg/day oral capsule
Refer to adult dosing
may diminish the serum concentration when combined with didanosine
may diminish the serum concentration when combined with didanosine
may diminish the serum concentration of quinolones
may diminish the serum concentration
ciprofloxacin inhaled (Pending FDA approval)Â
may diminish the serum concentration of Quinolones
when both drugs are combined, there may be an increased risk or severity of adverse effects   
may diminish the excretion rate of amantadine
When bacampicillin is combined with didanosine, bacampicillin absorption and blood levels decrease by stomach acid reduction.
didanosine reduces the therapeutic effects of demeclocycline by inhibiting GI absorption
didanosine reduces the therapeutic effects of doxycycline by inhibiting GI absorption
may enhance the serum concentration when combined with didanosine
may enhance the serum concentration when combined with didanosine
tenofovir disoproxil fumarate or tenofovir DFÂ
CD4+ cell count suppression and adverse reaction associated with didanosine, such as pancreatitis and neuropathy, is observed where levels of didanosine is increased when taken along with tenofovir DF, where it is recommended to stop didanosine
the activity of the anthrax vaccine can be reduced when used in combination with didanosine
rilpivirine decreases the absorption of didanosine
frequency defined
>10%
Skin rash
Increased serum cholesterol
1% to 10%
Angina pectoris
Facial edema
Myocardial infarction
Syncope
Peripheral neuropathy
Abnormal dreams
Anxiety
Confusion
Drowsiness
Disorientation
Disturbance in attention
Nervousness
Hypoesthesia
Prurigo
Night sweats
Xeroderma
Diabetes
lipohypertrophy
pancreatitis
stomatitis
anorexia
flatulence
gastritis
Post-marketing
Angioedema
Erythema multiforme
Hemorrhagic stroke
Rhabdomyolysis
Stevens-Johnson syndrome
Dress syndrome
Pregnancy consideration: Didanosine can transfer in some amounts across the human placenta.
Lactation: Didanosin excretion in breast milk is not known.
Â
Pregnancy category:
Patient information leaflet
Generic Name: didanosine
Why do we use didanosine?
didanosine, also known as ddI, is an antiretroviral medication used in the treatment of human immunodeficiency virus (HIV) infection. Here are the main reasons why didanosine is used:
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