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Brand Name :
Sulestrex, Improver, Harmogen
Synonyms :
estrone sulfate
Class :
Steroid hormone
Brand Name :
Sulestrex, Improver, Harmogen
Synonyms :
estrone sulfate
Class :
Steroid hormone
Dosage forms and strengths Â
Injectable solutionÂ
10 mg/mlÂ
Not indicatedÂ
Refer adult dosingÂ
it increases the effect of thrombogenesis of eptinezumab
in combination with ofatumumab, they increase the activity of thrombogenesis.
may increase the serum concentration of elagolix
it may diminish the metabolism when combined with diosmin
it may enhance the metabolism when combined with oxcarbazepine
when bromazepam and estrone sulfate are used together, there is a potential reduction in the bromazepam's metabolism
It may enhance the risk of adverse reactions when combined with Endogenous metabolites
When estrone sulfate is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
It may enhance the thrombogenic activities when combined with sotrovimab
It may diminish the metabolism when combined with Ergot alkaloids
It may diminish the metabolism when combined with Ergot alkaloids
It may diminish the metabolism when combined with Ergot alkaloids
It may diminish the metabolism when combined with Ergot alkaloids
It may diminish the metabolism when combined with Ergot alkaloids
It may diminish the metabolism when combined with Endothelin receptor antagonists
It may diminish the metabolism when combined with Endothelin receptor antagonists
It may diminish the metabolism when combined with Endothelin receptor antagonists
It may enhance the risk of adverse effects when combined with Monoclonal antibodies
It may enhance the risk of adverse effects when combined with Monoclonal antibodies
It may enhance the risk of adverse effects when combined with Monoclonal antibodies
It may enhance the risk of adverse effects when combined with Monoclonal antibodies
It may enhance the risk of adverse effects when combined with Monoclonal antibodies
abacavir leads to a reduction in the rate of excretion of estrone sulfate, which leads to an increased level of serum
acemetacin leads to a reduction in the rate of excretion of estrone sulfate, which leads to an increased level of serum
adefovir dipivoxil leads to a reduction in the rate of excretion of estrone sulfate, which leads to an increased level of serum
alclofenac leads to a reduction in the rate of excretion of estrone sulfate, which leads to an increased level of serum
aldesleukin leads to a reduction in the rate of excretion of estrone sulfate, which leads to an increased level of serum
When estrone sulfate is aided by hesperetin, it reduces hesperetin’s metabolism
Actions and Spectrum:Â
Action:Â
Estrone sulfate is a naturally occurring hormone and an estrogen derivative in the human body. Â
Estrone sulfate’s primary action is its conversion into estrone, which then serves various functions in the body by binding to estrogen receptors.
Frequency not defined Â
Breast tendernessÂ
Headache Â
Vaginal itchingÂ
Loss of scalp hairÂ
Darkening of facial skinÂ
Weight changesÂ
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
History of estrogen-sensitive cancers: Individuals with a history of certain estrogen-sensitive cancers, such as breast cancer or endometrial cancer, may be advised against using estrone sulfate due to its estrogenic effects that could potentially stimulate cancer growth.Â
Unexplained vaginal bleeding: Women experiencing unexplained vaginal bleeding should not use estrone sulfate until the cause is thoroughly assessed by a medical practitioner.Â
Known or suspected hormone-related conditions: This might include conditions such as endometriosis, uterine fibroids, or certain blood clotting disorders, where estrogen use could exacerbate the condition or increase the risk of complications.Â
Liver disease: patients with impaired liver function may have difficulty metabolizing estrone sulfate, leading to an increased risk of side effects.Â
History of blood clots or clotting disorders: Blood clot risk may be elevated by estrogen hormones, so individuals with a history of blood clots or clotting disorders may be advised against using estrone sulfate due to the increased risk of thromboembolic events.Â
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Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: Â
Estrone sulfate, a natural estrogenic hormone, has considerable importance in the functioning of the female reproductive system.Â
Pharmacodynamics:Â Â
Estrone sulfate, like other estrogens, exerts its effects by binding to estrogen receptors (ERs) present in various tissues, including the uterus, breast, bone, and brain. Upon binding to ERs, it initiates a cascade of cellular events leading to gene transcription, protein synthesis, and modulation of various physiological processes. Â
Pharmacokinetics:Â
AbsorptionÂ
Estrone sulfate can be absorbed through various routes. In oral administration, it’s absorbed from the gastrointestinal tract. However, the absorption may be limited due to its large size and polarity, leading to lower bioavailability.Â
DistributionÂ
Once absorbed, estrone sulfate circulates in the bloodstream, primarily bound to plasma proteins like albumin. Â
MetabolismÂ
Estrone sulfate can be metabolized in the body through various pathways. It can be converted back into estrone through the action of steroid sulfatase enzymes present in various tissues. Subsequently, estrone can be further metabolized into other estrogenic compounds. Metabolism can also involve sulfatase enzymes that can hydrolyze estrone sulfate, releasing estrone, and sulfate.Â
Excretion and EliminationÂ
Metabolites of estrone sulfate, including estrone and other estrogenic compounds, can be excreted from the body through urine and feces. These metabolites are conjugated with glucuronide or sulfate before being eliminated.Â
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Administration: Â
Oral Administration: Estrone sulfate is commonly available in oral tablet form. It is taken by mouth with a full glass of water. Usually, it’s advised to take it with food to reduce the likelihood of stomach upset.Â
Injection: In some cases, estrone sulfate may also be administered via intramuscular injection. This method is typically used when oral administration is not suitable for the patient or when a more immediate effect is needed.Â
Patient information leafletÂ
Generic Name: estrone sulfateÂ
Why do we use estrone sulfate? Â
In hormone replacement treatment, oestrogen sulphate and other oestrogen hormones are used to treat menopausal symptoms like mood swings, hot flashes, and dry vagina.Â
It helps to restore hormonal balance in women experiencing menopausal symptoms. Estrogens, including estrone sulfate, play a role in maintaining bone density. In postmenopausal women, hormone therapy containing estrone sulfate can help prevent or slow down osteoporosis, reducing the risk of bone fractures.Â
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