RyR1 Structural Alterations Explain Statin-Associated Muscle Dysfunction
December 16, 2025
Brand Name :
N/A
Synonyms :
ferric sulfate
Class :
Coagulant and hemostatic agent
Dosage Forms & Strengths
Liquid
210mg/ml
Gel
142mg/1g
In restorative dentistry, it is indicated as a hemostatic reagent, an antibacterial agent, and as pulpotomy medication to control pulpal bleeding
Not determined
Refer to adult dosing
phosphate binders: they may diminish the serum concentration of antacids
phosphate binders: they may diminish the serum concentration of antacids
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the serum concentration of magnesium salts
may have a decreased serum concentration when combined with phosphate supplements
may have a decreased serum concentration when combined with phosphate supplements
may have a decreased serum concentration when combined with phosphate supplements
may have a decreased serum concentration when combined with phosphate supplements
may have a decreased serum concentration when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
calcium salts: they may diminish the absorption of phosphate binders
calcium salts: they may diminish the absorption of phosphate binders
calcium salts: they may diminish the absorption of phosphate binders
calcium salts: they may diminish the absorption of phosphate binders
calcium salts: they may diminish the absorption of phosphate binders
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
l-methylfolate-pyridoxal 5′-phosphate-methylcobalamine
may diminish the serum concentration when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the serum concentration of magnesium salts
may decrease the serum concentration when combined
may decrease the effects of the drug by GI absorption inhibition
may decrease the effects of the drug by GI absorption inhibition
may decrease the effects of the drug by GI absorption inhibition
may decrease the effects of the drug by GI absorption inhibition
may decrease the effects of the drug by GI absorption inhibition
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
It may enhance the risk of adverse effects when combined with phosphate binders
It may enhance the risk of adverse effects when combined with phosphate binders
It may enhance the risk of adverse effects when combined with phosphate binders
It may enhance the risk of adverse effects when combined with phosphate binders
It may enhance the risk of adverse effects when combined with phosphate binders
may have an increased nephrotoxic effect when combined with NSAIDs
may have an increased nephrotoxic effect when combined with NSAIDs
may have an increased nephrotoxic effect when combined with NSAIDs
may have an increased nephrotoxic effect when combined with NSAIDs
may have an increased nephrotoxic effect when combined with NSAIDs
may have an increasingly adverse effect when combined with sodium phosphates
may have an increasingly adverse effect when combined with sodium phosphates
may have an increasingly adverse effect when combined with sodium phosphates
may have an increasingly adverse effect when combined with sodium phosphates
may have an increasingly adverse effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
spironolactone and hydrochlorothiazide
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
Actions and Spectrum
Ferric sulfate is primarily used as a hemostatic agent in various medical procedures. Direct application of ferric sulfate to the injured tissue results in the hemostatic effect. The formation of ferric ion-protein complexes by ferric sulfate helps in the mechanical sealing of damaged vessels.
Frequency not defined
None
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
The synthesis of hemoglobin and myoglobin requires elemental iron, which can be found in ferric sulfate. These are the proteins which body uses to carry and store oxygen.
Pharmacodynamics
Iron from ferric sulfate binds to protoporphyrin, forming heme, which is incorporated into hemoglobin and myoglobin.
These proteins are involved in the binding and release of oxygen, facilitating its transport to tissues and storage in muscles.
Pharmacokinetics
Limited information available on ADME.
Administration
Ferric sulfate is available in Gel, liquid, and solution form for topical use.
Patient information leaflet
Generic Name: ferric sulfate
Why do we use ferric sulfate?
Ferric sulfate is indicated as a hemostatic and coagulative agent.
In restorative dentistry, ferric sulfate is used as a hemostatic reagent, an antibacterial agent, and as pulpotomy medication to control pulpal bleeding.