indobufen

Action and Spectrum

Actions and Spectrum 

indobufen is used to prevent the formation of blood clots by inhibiting platelet aggregation. Platelets are blood cells that play a crucial role in blood clot formation. When platelets aggregate, they can form clots in blood vessels, which can lead to various cardiovascular problems, including heart attacks and strokes.

Drug Interaction

Adverse Reaction

Frequency not defined  

Haemostatic disorders  

Diarrhea  

Ulcer 

Bleeding

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• indobufen should not be used in individuals who have a known hypersensitivity or allergy to indobufen. 

Caution: 

• indobufen should be used cautiously in individuals with a history of gastrointestinal issues. 
• indobufen should be used with caution in patients with a history of heart failure and high blood pressure. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

indobufen achieves this by interfering with the function of platelet receptors. Inhibition of this receptor reduces platelet adhesion and aggregation, preventing the formation of pathological blood clots. 

Pharmacodynamics 

indobufen possesses anti-inflammatory properties. Its pharmacodynamic action involves inhibiting the activity of enzymes known as cyclooxygenases (COX).  

These enzymes are responsible for the production of prostaglandins, which are inflammatory mediators. 

Pharmacokinetics 

Absorption   

indobufen is absorbed from the gastrointestinal tract after oral administration.  

Distribution 

indobufen is distributed throughout the body. 

Metabolism 

indobufen undergoes hepatic metabolism.  

Elimination and excretion 

indobufen is excreted through the urine. 

Adminstartion

Administration 

indobufen is administered orally and available in tablet form.

Patient Information Leaflet

Patient information leaflet 

Generic Name: indobufen 

Why do we use indobufen? 

indobufen is used in the prevention of platelet aggregation which leads to thrombus formation.  

indobufen is used to prevent coronary and peripheral artery occlusion.