Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
N/A
Synonyms :
isometheptene, Isometheptene Mucate
Class :
Vasoconstrictor, Anti-spasmodics
Brand Name :
N/A
Synonyms :
isometheptene, Isometheptene Mucate
Class :
Vasoconstrictor, Anti-spasmodics
Dosage Forms & StrengthsÂ
TabletÂ
130 mgÂ
65 mgÂ
Acute migraine attacks
It is indicated in the management of acute migraine attacks
The usual recommended dose is 130 mg via oral administration SOS and then dose is reduced to half i.e., 65 mg per hour as required and the maximum dose limit is 325 mg per half day i.e., 12 hours
Dose Adjustments
Limited data is available
Dosage Forms & StrengthsÂ
TabletÂ
130 mgÂ
65 mg
Acute migraine attacks
There are limited studies where this medication is used and guided in the therapy of acute migraine attacks in children
It is indicated in the management of acute migraine attacks
The usual recommended dose is 130 mg via oral administration SOS and then dose is reduced to half i.e., 65 mg per hour as required and the maximum dose limit is 325 mg per half day i.e., 12 hours
Refer to the adult dosingÂ
may have an increasingly adverse effect when combined with isometheptene
may have an increasingly adverse effect when combined with isometheptene
may have an increasingly adverse effect when combined with isometheptene
may have an increasingly adverse effect when combined with isometheptene
may have an increasingly adverse effect when combined with isometheptene
the risk or extent of methemoglobinemia can be raised when amyl nitrite is combined with isometheptene
the risk or extent of tachycardia can be raised when anagrelide is combined with isometheptene
the risk or extent of methemoglobinemia can be raised when antipyrine is combined with isometheptene
the risk or extent of hypertension can be raised when antrafenine is combined with isometheptene
using isometheptene in conjunction with acebutolol can reduce the effectiveness of its treatment
when isometheptene is taken with aceclofenac, the risk or degree of BP may increase
when isometheptene is coupled with acemetacin, the risk or degree of BP may increase
when taken with isometheptene, acetaminophen can raise the risk or degree of methemoglobinemia
acetylsalicylic acid coupled with isometheptene can raise the risk or degree of bp
Actions and Spectrum:Â
Action:Â
Isometheptene narrows blood vessels, relieving headaches by reducing vessel dilation and associated pain.
Isomethheptene might relieve pain but mainly works by narrowing blood vessels.Â
Frequency not definedÂ
RashÂ
Blood disordersÂ
DizzinessÂ
Black Box Warning:Â Â
Using MAOIs and moclobemide simultaneously elevates the risk of hypertensive crisis. Â
Contraindication/Caution:Â
ContraindicationsÂ
HypersensitivityÂ
Cardiovascular disordersÂ
Severe Hepatic and renal impairmentÂ
CautionsÂ
Kidney diseaseÂ
Liver diseaseÂ
Cardiovascular diseasesÂ
Angle-closure glaucomaÂ
Pregnancy& breastfeedingÂ
Pregnancy/Lactation:Â
Pregnancy consideration:Â
Pregnancy category: CÂ
Breastfeeding warnings: No data is available regarding the excretion of drug in breast milk.Â
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.Â
Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.Â
Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.Â
Category N: No data is available for the drug under this category.Â
Pharmacology:Â
Isometheptene belongs to the group of sympathomimetic amine.Â
Pharmacodynamics:Â Â
Isomethheptene majorly causes vasoconstriction in the blood vessels with activation of alpha-adrenergic receptors which reduces blood flow in the cranial arteries hence relieving in symptoms associated with migraine & headaches.Â
Pharmacokinetics:Â
AbsorptionÂ
After taking orally, it quickly enters the bloodstream, within 1 to 2 hours peak plasma concentration is achieved.Â
Distribution Â
The drug distribution occurs through out the body.Â
Metabolism Â
Hepatic metabolism Â
Excretion and EliminationÂ
The excretion of the drug is through renal route.Â
Administration:Â Â
The route of administration is oral.Â
Patient information leafletÂ
Generic Name: IsomethepteneÂ
Pronounced: eye-soh-meth-EP-teenÂ
Why do we use isometheptene?Â
Isomethheptene is beneficial in treatment of headaches associated with tension and migraines.Â
The drug is also used as analgesics with other medications in OTC products.Â
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