Microplastics and Misinformation: What Science Really Says
November 12, 2025
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Brand Name :
Manerix; ALTI-Moclobemide
Synonyms :
moclobemide
Class :
Reversible Monoamine Oxidase Inhibitor, Antidepressant,
Brand Name :
Manerix; ALTI-Moclobemide
Synonyms :
moclobemide
Class :
Reversible Monoamine Oxidase Inhibitor, Antidepressant,
Dosage Forms & StrengthsÂ
TabletÂ
150mgÂ
300mgÂ
Initial dose: Administer 300mg in two divided doses every day. May gradually increase the dose beginning a week after the therapy.
Do not exceed 600mg/day.
Safety and efficacy not establishedÂ
Refer adult dosingÂ
benzhydrocodone/acetaminophenÂ
may increase the serotonergic effect of Monoamine Oxidase Inhibitors
may enhance serum concentrations of CYP2C19 Inhibitors
may increase the toxic effect when combined
may increase the hypertensive effect of Monoamine Oxidase Inhibitors
may increase the anticholinergic effect of Anticholinergic Agents
may increase the toxic effect of Monoamine Oxidase Inhibitors
may increase the toxic effect of Monoamine Oxidase Inhibitors
may increase the serotonergic effect of Monoamine Oxidase Inhibitors
may increase the serotonergic effect of Monoamine Oxidase Inhibitors
may increase the serotonergic effect of Monoamine Oxidase Inhibitors
may increase the serotonergic effect of Monoamine Oxidase Inhibitors
may increase the serotonergic effect of Monoamine Oxidase Inhibitors
may increase the serotonergic effect of Monoamine Oxidase Inhibitors
may increase the serotonergic effect of Monoamine Oxidase Inhibitors
may increase the serotonergic effect of Monoamine Oxidase Inhibitors
may increase the serotonergic effect of Monoamine Oxidase Inhibitors
may increase the serotonergic effect of Monoamine Oxidase Inhibitors
may increase the serotonergic effect of Monoamine Oxidase Inhibitors
may increase the serotonergic effect of Monoamine Oxidase Inhibitors
may increase the serotonergic effect of Monoamine Oxidase Inhibitors
may increase the serotonergic effect of Monoamine Oxidase Inhibitors
may increase the hypertensive effect of Monoamine Oxidase Inhibitors
may increase the hypertensive effect of Monoamine Oxidase Inhibitors
may increase the hypertensive effect of Monoamine Oxidase Inhibitors
may increase the hypertensive effect of Monoamine Oxidase Inhibitors
may increase the hypertensive effect of Monoamine Oxidase Inhibitors
may decrease the therapeutic effect of Anticholinergic Agents
may decrease the therapeutic effect of Anticholinergic Agents
may increase the toxic effect of Seizure Threshold, Lowering Potential agents
may increase the toxic effect of Seizure Threshold, Lowering Potential agents
may increase the toxic effect of Seizure Threshold, Lowering Potential agents
may increase the toxic effect of Seizure Threshold, Lowering Potential agents
may increase the toxic effect of Seizure Threshold, Lowering Potential agents
may enhance the serum concentration of Anticholinergic Agents
may enhance the serum concentration of Anticholinergic Agents
may enhance the serum concentration of Anticholinergic Agents
may enhance the serum concentration of Anticholinergic Agents
When dexrabeprazole and moclobemide is used together, this leads to reduction in the dexrabeprazole’s metabolism
When encainide is used together with moclobemide, this leads to a reduction in the encainide’s metabolism
Actions and Spectrum:Â
Mechanism of ActionÂ
moclobemide works by inhibiting the activity of monoamine oxidase type A (MAO-A) enzymes in the brain. MAO-A breaks down neurotransmitters such as serotonin, norepinephrine, and dopamine. By inhibiting MAO-A, moclobemide increases the levels of these neurotransmitters in the brain.Â
The increased serotonin, norepinephrine, and dopamine levels enhance neurotransmission and improve mood regulation. This mechanism is thought to alleviate depressive symptoms and improve emotional well-being.Â
Spectrum of ActivityÂ
moclobemide is primarily used to treat major depressive disorder (MDD) or clinical depression. It is effective in managing mild to moderate depression and can be particularly useful in cases where anxiety is a significant symptom. By increasing serotonin levels, moclobemide can help reduce anxiety and improve social functioning in individuals with this disorder.Â
Frequency definedÂ
1-10%Â
Palpitations Â
Acute anxietyÂ
Agitation Â
TremorÂ
Diarrhea Â
Hypotension Â
TachycardiaÂ
InsomniaÂ
Constipation Â
Gastrointestinal diseaseÂ
Frequency not definedÂ
Heavy menstrual bleedingÂ
Hot flashÂ
Musculoskeletal painÂ
DyspneaÂ
Black box warning:Â
NoneÂ
Contraindications/caution:Â
Contraindications:Â
Caution:Â
Pregnancy consideration: Animal reproduction studies have revealed adverse effects.Â
Lactation: Excretion of the drug in human breast milk is known in small quantitiesÂ
Pregnancy category:Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this categoryÂ
Pharmacology:Â
Pharmacodynamics:Â Â
The pharmacodynamics of moclobemide involves the selective inhibition of MAO-A, resulting in increased serotonin, norepinephrine, and dopamine levels, collectively contributing to its antidepressant effects.Â
Pharmacokinetics:Â
AbsorptionÂ
Approximately 98% of the medication is absorbed from the gastrointestinal (GI) tract.Â
Onset of Action: Initial effects may be observed within 1 to 2 weeks of treatment, with continued improvements through 4 to 6 weeks.Â
The bioavailability of the drug is approximately 55% after a single dose. With repeated dosing, the bioavailability increases to approximately 90%, indicating that the drug accumulates in the body with continued use.Â
DistributionÂ
The volume of distribution is approximately 1.2 L/kg. This value indicates that the drug is distributed throughout the body tissues. Approximately 50% of the drug is bound to plasma proteins, primarily to albumin. Protein binding affects the drug’s distribution and elimination from the body.Â
MetabolismÂ
The drug is extensively metabolized in the liver through hepatic oxidative reactions. Partial metabolism of the drug occurs via the cytochrome P450 enzymes CYP2C19 and CYP2D6. These enzymes are involved in the metabolism of various drugs.Â
Elimination and ExcretionÂ
The terminal half-life of the drug is 1.5 hours. Approximately 95% of the drug and its metabolites are excreted in the urine. Less than 1% of the drug is excreted unchanged (in its original form) in the urine.Â
Administration:Â
Oral administrationÂ
Take along with the meals as it helps to reduce the risk of gastrointestinal side effects, such as nausea and stomach upset.Â
Patient information leafletÂ
Generic Name: moclobemideÂ
Why do we use moclobemide?Â
moclobemide is an antidepressant medication used primarily for treating major depressive disorder (MDD) and social anxiety disorder (social phobia). Here are the primary uses of moclobemide:Â
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