Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
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Brand Name :
Lacivas
Synonyms :
lacidipine
Class :
Calcium channel blocker
Dosage Forms & StrengthsÂ
TabletÂ
2mgÂ
4mgÂ
Initial dose-administer 2mg orally in the morning. may increase the dose to 4mg/day after 3 to 4 weeks.
Do not exceed 6mg/day.
Safety and efficacy not establishedÂ
Refer adult dosingÂ
lacidipine: it may enhance the serum concentration of simvastatin
CYP3A strong enhancers of the small intestine may reduce the bioavailability of lacidipine
may have an increased hyperkalemic effect when combined with calcium channel blockers
may have an increased hypotensive effect when combined with calcium channel blockers
bunazosin (Not available in the United States)
may have an increased hypotensive effect when combined with calcium channel blockers
may have an increased hypotensive effect when combined with calcium channel blockers
may have an increased hypotensive effect when combined with calcium channel blockers
may have an increased hypotensive effect when combined with calcium channel blockers
may enhance the AV-blocking effect of cardiac glycosides
may enhance the AV-blocking effect of cardiac glycosides
may enhance the AV-blocking effect of cardiac glycosides
it may enhance the risk of QTc prolongation when combined with amifampridine
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may increase the hypotensive effect of alpha1-blockers
bunazosin (Not available in the United States)
may increase the hypotensive effect of alpha1-blockers
may increase the hypotensive effect of alpha1-blockers
may increase the hypotensive effect of alpha1-blockers
may increase the hypotensive effect of alpha1-blockers
may increase the hypotensive effect of alpha1-blockers
may increase the hypotensive effect of alpha1-blockers
bunazosin (Not available in the United States)
may increase the hypotensive effect of alpha1-blockers
may increase the hypotensive effect of alpha1-blockers
may increase the hypotensive effect of alpha1-blockers
may decrease the therapeutic effect of calcium salts
may decrease the therapeutic effect of calcium salts
may decrease the therapeutic effect of calcium salts
may decrease the therapeutic effect of calcium salts
may decrease the therapeutic effect of calcium salts
may have an increasingly adverse effect when combined with atosiban
inhalational anesthetics increase the effect of hypotension of calcium channel blockers
inhalational anesthetics increase the effect of hypotension of calcium channel blockers
inhalational anesthetics increase the effect of hypotension of calcium channel blockers
inhalational anesthetics increase the effect of hypotension of calcium channel blockers
inhalational anesthetics increase the effect of hypotension of calcium channel blockers
It may enhance the risk of adverse effects when combined with antianginal drugs
It may enhance the risk of adverse effects when combined with antianginal drugs
It may enhance the risk of adverse effects when combined with antianginal drugs
It may enhance the risk of adverse effects when combined with antianginal drugs
It may enhance the risk of adverse effects when combined with antianginal drugs
Actions and Spectrum:Â
lacidipine blocks calcium channels in vascular smooth muscle cells, specifically the L-type calcium channels. These channels allow calcium ions to enter cells, which triggers muscle contraction. By blocking these channels, lacidipine reduces calcium entry into the smooth muscle cells of blood vessels. This leads to relaxation and dilation of the blood vessels, decreasing peripheral vascular resistance and lower blood pressure.Â
In addition to its effects on blood vessels, lacidipine’s calcium channel-blocking action can also impact the heart by reducing the force and rate of heart contractions, thus contributing to its antihypertensive effects. lacidipine is primarily used to treat hypertension (high blood pressure). Its spectrum of activity is focused on lowering blood pressure by targeting the cardiovascular system:Â
Frequency definedÂ
NoneÂ
Black box warning:Â
NoneÂ
Contraindications/caution:Â
Contraindications:Â
Caution:Â
Pregnancy consideration: Insufficient data availableÂ
Lactation: Excretion of the drug in human breast milk is unknownÂ
Pregnancy category:Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this categoryÂ
Pharmacology:Â
Pharmacokinetics:Â
AbsorptionÂ
lacidipine is administered orally in tablet form. It is well-absorbed from the gastrointestinal tract after oral ingestion. However, the absorption process can be affected by factors such as food intake, which can delay absorption and reduce the peak concentration of the drug in the bloodstream.Â
DistributionÂ
Once absorbed into the bloodstream, lacidipine is distributed throughout the body, with its primary target being the smooth muscle cells in blood vessels. It selectively blocks L-type calcium channels in these cells, leading to vasodilation and reduced blood pressure.Â
MetabolismÂ
lacidipine undergoes extensive metabolism in the liver. It is primarily metabolized via the cytochrome P450 (CYP) enzyme system, particularly CYP3A4. The metabolites formed are pharmacologically inactive and are excreted from the body.Â
Elimination and ExcretionÂ
The metabolites of lacidipine are primarily excreted through the bile and eliminated from the body in the feces. The kidney’s role in the excretion of lacidipine and its metabolites is relatively minor compared to the hepatic excretion.Â
Administration:Â
Oral administrationÂ
lacidipine tablets should be swallowed whole with a glass of water. Do not chew, or break the tablets.Â
Patient information leafletÂ
Generic Name: lacidipineÂ
Why do we use lacidipine?Â
lacidipine is primarily used to treat hypertension, which is high blood pressure. It belongs to the class of medications known as calcium channel blockers, specifically dihydropyridines. Here are the primary uses of lacidipine:Â
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