Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
rezlidhia
Synonyms :
olutasidenib
Class :
Anti-neoplastic, Isocitrate dehydrogenase 1
Brand Name :
rezlidhia
Synonyms :
olutasidenib
Class :
Anti-neoplastic, Isocitrate dehydrogenase 1
Dosage Forms & StrengthsÂ
CapsuleÂ
150mgÂ
150
mg
Capsules
Orally 
twice a day
until the disease progresses
Dose Adjustments
Differentiation syndrome
Withhold REZLIDHIA if differentiation syndrome is suspected until signs and symptoms become improved
Systemic corticosteroids should be given; hemodynamic monitoring should start and continue for at least three days after symptom remission
Restart REZLIDHIA at 150 mg twice daily once the differentiation syndrome has subsided.
may diminish the serum concentration of CYP3A4 Inducers
may diminish the serum concentration of CYP3A4 substrates
it may decrease by affecting the hepatic enzyme CYP3A4 metabolism
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
olutasidenib: they may diminish the serum concentration of CYP3A4 Inducers
olutasidenib: they may diminish the serum concentration of CYP3A4 Inducers
olutasidenib: they may diminish the serum concentration of CYP3A4 Inducers
olutasidenib: they may diminish the serum concentration of CYP3A4 Inducers
olutasidenib: they may diminish the serum concentration of CYP3A4 Inducers
it may enhance the metabolism when combined with aripiprazole lauroxil
Frequency defined:Â Â
>10%Â
All gradesÂ
ALT decreasedÂ
Sodium decreasedÂ
Creatinine decreasedÂ
ArthralgiaÂ
Bilirubin increasedÂ
PyrexiaÂ
RashÂ
DiarrheaÂ
EdemaÂ
VomitingÂ
Decreased appetiteÂ
LeukocytosisÂ
Abdominal painÂ
MucositisÂ
Increased uric acidÂ
CoughÂ
Grades 3 and 4Â
ALT increasedÂ
1-10%Â
All gradesÂ
Grades 3 and 4Â
Potassium decreasedÂ
Lipase increasedÂ
HypertensionÂ
EdemaÂ
ArthralgiaÂ
Creatinine decreasedÂ
Differentiation syndromeÂ
DiarrheaÂ
Sodium decreasedÂ
Abdominal pain Â
CoughÂ
Uric acid increasedÂ
PyrexiaÂ
rashÂ
Pregnancy consideration: Not recommended as it may cause fetal harmÂ
Lactation: Excretion of the drug in human breast milk is unknownÂ
Pregnancy category:Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.  Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this categoryÂ
Patient information leafletÂ
Generic Name: olutasidenibÂ
Pronounced: olu-ta-si-dee-neebÂ
Why do we use olutasidenib?Â
It is an isocitrate dehydrogenase-1 (IDH1) inhibitor prescribed for the treatment of patients with relapsed or resistant acute myeloid leukemia (AML)Â
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