oxybuprocaine

Action and Spectrum

Actions and Spectrum 

oxybuprocaine works by blocking nerve impulses in the targeted area specifically the nerve endings responsible for transmitting pain signals. By inhibiting the flow of sodium ions into the nerve cells, preventing the generation and propagation of action potentials along the nerves.

Drug Interaction

Adverse Reaction

Frequency not defined  

Corneal damage 

Oedema 

Epithelial corneal damage   

Allergic reactions  

Peripheral corneal formation 

Burning sensation  

Transient stinging 

Keratitis   

Occasional nausea 

Blurred vision 

Vomiting 

Dysphagia 

Stromal infiltration  

Candida keratitis

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Individuals with a known hypersensitivity or allergy to oxybuprocaine or any of its components should not use this medication. 

Caution: 

• oxybuprocaine should be used cautiously in individuals with corneal abrasions or ulcers. 
• oxybuprocaine should be used with caution in cases of eye infections.  
• Contact lens users should remove their lenses before using oxybuprocaine.

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: C 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

The mechanism of action involves blocking voltage-gated sodium channels in nerve cell membranes.  

This leads to a reversible loss of sensation and pain in the area where the drug is applied. 

Pharmacodynamics 

When applied to the eye’s surface, oxybuprocaine temporarily numbs the area, making it ideal for various ophthalmic procedures and examinations.  

The loss of sensation occurs because nerve impulses cannot propagate along with the nerves. 

Pharmacokinetics 

Absorption   

oxybuprocaine absorbed through the conjunctival and corneal epithelium after topical administration into the eye.  

Distribution 

oxybuprocaine’s distribution is localized to the ocular tissues. 

Metabolism 

oxybuprocaine undergoes metabolism through hydrolysis by esterases.  

Elimination and excretion 

oxybuprocaine is eliminated from the body through the urine.

Adminstartion

Administration 

oxybuprocaine is administered into the eyes as an ophthalmic solution i.e., in form of eye drops. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: oxybuprocaine 

Why do we use oxybuprocaine? 

oxybuprocaine can provide relief to individuals with corneal abrasions as it reduces the pain associated with blinking and eye movement. oxybuprocaine can be used to numb the eye and make the removal process more comfortable.