Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Opana
Synonyms :
oxymorphone
Class :
Opioid Analgesics
Brand Name :
Opana
Synonyms :
oxymorphone
Class :
Opioid Analgesics
Dosage Forms & Strengths  Â
Immediate release (tablet): Schedule IIÂ
5 mgÂ
10 mgÂ
Extended release (tablet): Schedule IIÂ
Moderate to severe painÂ
5 mg, 15 mg, 20 mg, 30 mg;Â Â
7.5 mg, 10 mg, 40 mgÂ
Patients who have not previously taken opioids (immediate release): 10 to 20 mg taken orally every 4 to 6 hours as required at first, and then adjusted as necessary.
Extended-release tablet initial dosing Patients who have not previously taken opioids or do not have a tolerance: should begin with a dose of 5 mg administered orally every 12 hours. The dosage should then be adjusted gradually in increments of 5 to 10 mg after every 3 to 7 days until a level is reached that effectively relieves pain while minimizing any potential adverse effects Patients who have developed tolerance to opioids: Patients who have been taking a minimum dosage of 60 mg/day orally for morphine, 25 mcg/hr transdermal fentanyl, 30 mg/day orally for oxycodone, 8 mg/day orally for hydromorphone, 25 mg/day orally for oxymorphone, or an equivalent amount of another opioid for a period of one week or more.
Dosage Forms & Strengths  Â
Safety and efficacy not determinedÂ
Refer to adult dosing
may have an increased Effect of CNS depressant when combined with serotonergic opioids
it increases the effect of CNS depressants
CNS depressants increase the effect of paraldehyde
CNS depressants increase the CNS depressing effect of thalidomide
CNS depressants increase the effect of flunarizine
it increases the effect of CNS depressants
may reduce the analgesic effect of Opioid agonists
may reduce the analgesic effect of Opioid agonists
may reduce the analgesic effect of Opioid agonists
may reduce the analgesic effect of Opioid agonists
It may enhance sedation when combined with a shepherd's purse
may reduce the therapeutic effect
may reduce the therapeutic effect
may reduce the therapeutic effect
When encainide is used together with oxymorphone, this leads to a reduction in the encainide’s metabolism
lofexidine may enhance the CNS depressant effect of CNS depressants
may increase the CNS depressant effect
may enhance the activity
may increase the CNS depressant effect
may increase the CNS depressant effect
may increase the CNS depressant effect
may increase the sedative effect of CNS depressants
may increase the CNS depressant effect
it increases the effect of CNS depressants
Actions and Spectrum:Â
It is an opioid analgesic used to treat moderate to severe pain by attaching to central nervous system receptors. Its main action is analgesic but it can cause negative side effects like respiratory depression and drowsiness.Â
Frequency defined Â
1-10%Â
Somnolence (9%)Â
Constipation (4%)Â
Pruritus (8%)Â
Confusion (3%)Â
Headache (7%)Â
Dizziness (7%Â
Vomiting (9%)Â
1 to <10%Â
cardiac disorders: tachycardiaÂ
Gastrointestinal disorders: abdominal distention, dry mouth and flatulenceÂ
Respiratory, thoracic and mediastinal disorders: hypoxiaÂ
Vascular disorders: hypotensionÂ
General disorders and administration site conditions: sweating increasedÂ
Nervous system disorders: sedation and anxiety Â
<1%Â
AgitationÂ
CNS depressionÂ
Hot flashesÂ
UrticariaÂ
WeaknessÂ
DehydrationÂ
DermatitisÂ
Mental impairmentÂ
Visual disturbancesÂ
Mental status changesÂ
InsomniaÂ
Weight decreasedÂ
MiosisÂ
DyspepsiaÂ
Respiratory rate decreasedÂ
Oxygen saturation decreasedÂ
Difficult micturitionÂ
Urinary retentionÂ
Vision blurredÂ
Depressed level of consciousnessÂ
DisorientationÂ
RestlessnessÂ
Allergic reactionsÂ
Respiratory depressionÂ
Respiratory distressÂ
Euphoric moodÂ
HallucinationÂ
Appetite decreasedÂ
BradycardiaÂ
LethargyÂ
FatigueÂ
DepressionÂ
PalpitationÂ
Postural hypotensionÂ
HypersensitivityÂ
ClamminessÂ
FlushingÂ
NervousnessÂ
SyncopeÂ
DyspneaÂ
DysphoriaÂ
EdemaÂ
Feeling jitteryÂ
Abdominal painÂ
IleusÂ
DiarrheaÂ
Post marketing reportsÂ
Nervous system disorder: convulsion, memory impairment, AmnesiaÂ
AnaphylaxisÂ
Adrenal insufficiency: Cases of adrenal insufficiency have been reported with opioid use, more often following greater than one month of useÂ
Immune system disorders: other hypersensitivity reactions and angioedemaÂ
Androgen deficiency: Cases of androgen deficiency have occurred with chronic use of opioidsÂ
Serotonin syndrome: Cases of serotonin syndrome, have been reported during concomitant use of opioids with serotonergic drugs, a potentially life-threatening conditionÂ
>10%Â
Pyrexia (14%)Â
Nausea (19%)Â
Black Box WarningÂ
Overdose leads to death and likely respiratory depressionÂ
Contraindication/Caution:Â
Oxymorphone is contraindicated for individuals with intolerance to its ingredients, respiratory depression, gastrointestinal blockage, or severe bronchial asthma.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excretion into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
PharmacologyÂ
Oxymorphone reduces pain perception and promotes well-being by attaching to mu, delta, and kappa receptors.Â
Pharmacodynamics Â
Oxymorphone actions are on the central nervous system specifically mu, delta, and kappa opioid receptors. Its potency is high due to its strong affinity for these receptors.Â
PharmacokineticsÂ
Absorption Â
Efficiently absorbed Â
DistributionÂ
oxymorphone has a strong affinity for albumin and other proteins.Â
MetabolismÂ
Cytochrome P450 enzymes also break down oxymorphone.Â
Elimination and excretionÂ
Elimination half-life is around 7 to 9 hours.Â
Administration: Â
Oxymorphone comes in various forms including immediate-release and extended-release pills which are typically taken every 4 to 6 hours to manage pain.Â
Patient information leafletÂ
Generic Name: oxymorphoneÂ
Why do we use oxymorphone?Â
Oxymorphone is a strong opioid analgesic used to manage moderate to severe pain in adults including those who suffering from chronic illnesses like cancer, surgery, and trauma.Â
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
