patent blue

Action and Spectrum

Actions and Spectrum: 

patent blue, also known as patent blue V or E131, is a synthetic dye commonly used in medical and industrial applications. It has several uses, including being used as a dye in medical diagnostics and surgery.  

• Surgical Use: In surgical procedures, patent Blue is often used as a lymphatic dye. It is injected near the site of the tumor or lymph node, and it selectively stains lymphatic vessels and nodes. patent blue aids surgeons in identifying lymphatic vessels and nodes during procedures like sentinel lymph node mapping in cancer surgery. It helps surgeons visualize the lymphatic drainage pathways and identify the first (sentinel) lymph node that receives drainage from a tumor. 
• Diagnostic Use: In diagnostic procedures, Patent Blue is used as a contrast agent. It is employed in various medical imaging studies, such as lymphography, to enhance visualization of lymphatic vessels. It absorbs light in the blue-green spectrum, making it suitable for visualization under certain lighting conditions. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Respiratory reactions 

Skin reactions 

Anaphylactic shock 

cardiovascular reactions 

Hypersensitivity 

Angio-edema 

Urticaria 

Bronchospasm 

Black Box Warning

Black box warning: 

None 

Contraindication / Caution

Contraindications/caution: 

Hypersensitivity 

Renal impairment 

Pregnancy / Lactation

Pregnancy consideration: Insufficient data available 

Lactation: It has not been studied in breast milk 

Pregnancy category: 

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category 

Pharmacology

Pharmacology: 

Binding and Visualization: 

• patent blue is used in medical applications as a dye for visualization purposes. When injected into the body, it binds selectively to tissues or structures, aiding in their visualization during various procedures. 
• In medical imaging, patent blue may be used to enhance the visualization of lymphatic vessels and nodes. For example, sentinel lymph node mapping during cancer surgery helps surgeons identify and navigate lymphatic pathways. 

Pharmacokinetics: 

Absorption 

patent blue is typically administered through intravenous injection or, in some cases, subcutaneous injection. Following injection, Patent Blue is absorbed into the bloodstream. 

Distribution 

patent blue tends to bind selectively to specific tissues or structures, allowing for enhanced visualization during medical procedures. The dye’s distribution in the body is influenced by factors such as blood flow and tissue affinity. 

Metabolism 

patent blue is not metabolized in the body in the same way that traditional drugs are. Its structure remains relatively stable, and it is mainly excreted unchanged. 

Elimination and Excretion 

patent blue is primarily eliminated from the body through excretion. The specific route of excretion may involve both renal and biliary pathways, depending on factors such as the dye’s molecular size and charge. 

Adminstartion

Administration: 

Intravenous administration 

patent blue is typically administered through intravenous (IV) injection. The injection may be performed directly into a vein, often in the arm or hand. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: patent blue 

Why do we use patent blue? 

patent blue, also known as patent blue V or E131, is a synthetic dye with various uses in medical, industrial, and other applications.  

Surgical Procedures: 

• Lymphatic Mapping: patent blue is commonly used in surgical procedures, particularly in cancer surgery. It is injected near the tumor site to visualize and map the lymphatic drainage pathways. This helps surgeons identify sentinel lymph nodes, aiding in cancer staging and treatment decisions. 

Sentinel Lymph Node Biopsy: 

• Cancer Staging: In cancer surgery, particularly in breast cancer and melanoma, patent blue is used for sentinel lymph node biopsy.  

Diagnostic Imaging: 

• Lymphography: patent blue may be used in medical imaging studies, such as lymphography, to enhance the visualization of lymphatic vessels and nodes. This can aid in the diagnosis and evaluation of conditions affecting the lymphatic system. 

Food Industry: 

• Food Coloring: patent blue is used as a food colorant in some countries. It is added to certain food products to impart a blue or green color. 

Industrial Applications: 

• Dyeing: In industrial applications, patent blue may be used as a dye in textiles, paper, and other materials.