Effectiveness of Tai Chi vs Cognitive Behavioural Therapy for Insomnia in Middle-Aged and Older Adults
November 27, 2025
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Brand Name :
Permax
(United States) [DSC]Synonyms :
pergolide
Class :
Antiparkinsonian Drugs
Dosage Forms & Strengths
Tablet
0.05 mg
0.25 mg
1 mg
Take an initial dose of 50 mcg orally in the evening on day 1, then raised up to 50 mcg two times a day on days 2 to 4
Raised dose by 100 to 250 mcg every 3 to 4 days in 3 divided doses up to a daily dose of 1.5 mg at day 28
After day 30, dose is raised up to max of 250 mcg two times day weekly
Take a maintenance dose of 2.1 to 2.5 mg orally daily in 3 divided doses
Take an initial dose of 0.05 mg orally one time in a day
Dosage Forms & Strengths
Tablet
0.05 mg
0.25 mg
1 mg
for 8 to 17 years old:
Take a dose of 25 mcg daily then 2 to 3 days later the dose was titrated up to 50 mcg thrice daily
Refer to adult dosing
it increases the effect of hypertension of alpha-1 agonists
may have an increased hypertensive effect when combined with alpha-/beta-agonists
It may increase the hypertensive effect when combined with Alpha-/Beta-Agonists
It may increase the hypertensive effect when combined with Alpha-/Beta-Agonists
It may increase the hypertensive effect when combined with Alpha-/Beta-Agonists
It may increase the hypertensive effect when combined with Alpha-/Beta-Agonists
It may increase the hypertensive effect when combined with Alpha-/Beta-Agonists
may have an increasingly adverse effect when combined with ergot derivatives
may have an increasingly adverse effect when combined with ergot derivatives
may have an increasingly adverse effect when combined with ergot derivatives
may have an increasingly adverse effect when combined with ergot derivatives
may have an increasingly adverse effect when combined with ergot derivatives
pergolide: they may increase the hypertensive effect of sympathomimetics
pergolide: they may increase the hypertensive effect of sympathomimetics
pergolide: they may increase the hypertensive effect of sympathomimetics
pergolide: they may increase the hypertensive effect of sympathomimetics
pergolide: they may increase the hypertensive effect of sympathomimetics
pergolide: they may increase the hypertensive effect of Alpha2-Agonists
pergolide: it may increase the risk of CNS depression
pergolide: it may increase the risk of CNS depression
pergolide: it may increase the risk of CNS depression
pergolide: it may increase the risk of CNS depression
pergolide: it may increase the risk of CNS depression
may increase the hypertension effect of alfa one agonist
Actions and Spectrum
pergolide targets dopamine receptors in the brain. It acts as a direct agonist i.e., it binds to these receptors and activates them in a manner like dopamine. This can help improve motor control and reduce the symptoms of conditions like Parkinson’s disease, which is characterized by a deficiency of dopamine in certain parts of the brain responsible for movement regulation.
Frequency not defined
Exacerbate confusion
Hallucinations
Somnolence
Sudden sleep onset
Dyskinesia
Impulse control disorders
Atrial premature contractions
Sinus tachycardia
Orthostatic and sustained hypotension
Headache
Dizziness
Asthenia
Extra pyramidal syndrome
Akinesia
Dystonia
Hypertonia
Neuralgia
Speech disorder
Tremor
Abnormal gait
Anxiety
Depression
Psychosis
Incoordination flu-syndrome
Chest pain
Palpitations
Syncope
Vasodilation
Peripheral oedema
Nausea
Diarrhea
Dyspepsia
Abdominal pain
Dry mouth
Dysphagia
Rhinitis
Hiccups
Epistaxis
Urinary frequency
Back and neck pain
Arthralgia
Myalgia
Twitching
Dystonia
Abnormal vision
Diplopia
Eye disorder
Sweating
Facial oedema
Pain
Chills
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: B
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
pergolide can stimulate dopamine signaling in brain regions that are affected in Parkinson’s disease, potentially improving motor symptoms. pergolide’s impact on dopamine receptors in the pituitary gland can lower the secretion of prolactin, which is important in conditions involving elevated prolactin levels.
Pharmacodynamics
pergolide affects the pituitary gland’s regulation of prolactin secretion. The elevated prolactin levels can lead to various hormonal imbalances and associated symptoms.
Pharmacokinetics
Absorption
pergolide is absorbed from the gastrointestinal tract into the bloodstream.
Distribution
pergolide is distributed throughout the body.
Metabolism
pergolide is metabolized primarily in the liver.
Elimination and excretion
pergolide is excreted from the body through urine and feces.
Administration
pergolide is administered orally and it is available in the form of tablets.
Patient information leaflet
Generic Name: pergolide
Why do we use pergolide?
pergolide was used to manage the motor symptoms of Parkinson’s disease, which include tremors, bradykinesia, and rigidity.
pergolide was also used to lower elevated levels of prolactin, it is a hormone which produced by the pituitary gland.
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