Microplastics and Misinformation: What Science Really Says
November 12, 2025
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Brand Name :
Lomaira, Adipex P
Synonyms :
Fentermina, Phentermine resin, Phentermine, Phenterminum
Class :
Anorexiants, CNS stimulants
Brand Name :
Lomaira, Adipex P
Synonyms :
Fentermina, Phentermine resin, Phentermine, Phenterminum
Class :
Anorexiants, CNS stimulants
Dosage Forms & Strengths
Capsule
15mg
30mg
37.5mg-Adipex P
Tablet
8mg-Lomaira
37.5mg-Adipex P
8 mg orally thrice daily or 15 or 30 mg capsules orally daily or 37.5 mg tablets orally daily
Dosage Forms & Strengths
Capsule
15mg
30mg
37.5mg-Adipex P
Tablet
8mg-Lomaira
37.5mg-Adipex P
Age: >16 years
Lomira: 8 mg orally thrice daily 30 minutes before meals
Capsules: 15 or 30 mg orally daily 2 hours after breakfast
Adipex-P: 37.5 mg orally daily before breakfast or 1-2 hours after breakfast
Refer adult dosing
Amphetamines may reduce the antihypertensive effect of antihypertensive Agents.
Amphetamines may reduce the antihypertensive effect of antihypertensive Agents.
Amphetamines may reduce the antihypertensive effect of antihypertensive Agents.
Amphetamines may reduce the antihypertensive effect of antihypertensive Agents.
Amphetamines may reduce the antihypertensive effect of antihypertensive Agents.
amphetamines may enhance the cardiotoxic effect of quinolones
amphetamines may enhance the cardiotoxic effect of quinolones
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
it decreases the efficacy of antihypertensive agents
it may increase the effect of serotonergic agents
carbonic Anhydrase Inhibitors may reduce the rate of excretion of amphetamines
carbonic Anhydrase Inhibitors may reduce the rate of excretion of amphetamines
carbonic Anhydrase Inhibitors may reduce the rate of excretion of amphetamines
carbonic Anhydrase Inhibitors may reduce the rate of excretion of amphetamines
carbonic Anhydrase Inhibitors may reduce the rate of excretion of amphetamines
antipsychotic Agents may enhance the adverse/toxic effect of amphetamines
antipsychotic Agents may enhance the adverse/toxic effect of amphetamines
antipsychotic Agents may enhance the adverse/toxic effect of amphetamines
antipsychotic Agents may enhance the adverse/toxic effect of amphetamines
antipsychotic Agents may enhance the adverse/toxic effect of amphetamines
antipsychotic Agents may enhance the adverse/toxic effect of amphetamines
antipsychotic Agents may enhance the adverse/toxic effect of amphetamines
antipsychotic Agents may enhance the adverse/toxic effect of amphetamines
antipsychotic Agents may enhance the adverse/toxic effect of amphetamines
antipsychotic Agents may enhance the adverse/toxic effect of amphetamines
may enhance the serotonergic effect of serotonergic Agents
When phentermine is used together in combination with profenamine, this leads to reduction in therapeutic effectiveness of profenamine
chloroprocaine: it may increase the risk of methemoglobinemia with pheneticillin
The phentermine drug action involves norepinephrine release by activating CNS and suppress appetite. The studies of randomized controlled trials showed that obese women receiving continuous treatment has lost a substantial 13% of their body weight. Phentermine reduces the likelihood of this happening when weight loss is the goal.
Frequency Not Defined
Changes in libido
Chills
Hair loss
Blurred vision
Headache
Palpitations
Constipation
Diarrhea
Drug-induced GI disturbance
Dry mouth
Dysphoric mood
Dysuria
Excitement
Restlessness
Tachycardia
Tremor
Urticaria
Hypertension
Impotence
Insomnia
Myalgia
Nausea
Nervousness
Black Box Warning:
The potential side effects of this drug has cardiac problems and pulmonary hypertension. Once tolerance develops the drug needs to be discontinued.
Contraindication/Caution:
Contraindications:
Hypersensitive to few allergic drugs and contraindicated in pregnancy/breastfeeding.
Caution:
A caution needs to be taken when patients with renal/hepatic impairment, diabetes, and drug interactions.
A new study focuses on pregnancy weight guidelines for obese women.
Pregnancy Warnings:
Pregnancy category:
AU TGA pregnancy category: B2
US FDA pregnancy category: X
Lactation:
Excretion of the drug in human breast milk is unknown
Pregnancy Categories:
Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.
Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.
Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology:
Phentermine acts as indirect sympathomimetic drug which stimulates the release of noradrenaline and increase beta-2 receptor activity altering the levels of serotonin.
Pharmacodynamics:
Phentermine is an amphetamine analog that reduces hunger by increasing the levels of leptin and increasing resting energy consumption resulting in weight loss.
Research studies indicates that 3.6 kg weight reduction showed in 2–24 weeks by continuing maintenance.
Pharmacokinetics:
Absorption:
The plasma concentration is 200 ng/ml and its peak concentration is 6 hours where high fat meals have small effect on bioavailability.
Distributed:
The volume of distribution shows 5 L/kg
Metabolism:
Approximately 6% from the given dose undergoes metabolism followed phentermine for having 5% of the total being N-oxidized and N-hydroxylated metabolites.
Excretion:
Between 70 and 80 percent of the recommended dose is eliminated unchanged in urine.
Administration:
The route of administration is oral, given in the morning to avoid sleeplessness because of its stimulating properties.
The duration of the drug is for short term period
Patient Information Leaflet
Generic Name: phentermine
Why do we use phentermine?
Phentermine functions similar to amphetamine, stimulating central nervous system by suppresses cravings. This helps the individuals who are overweight prevent risk factors like high blood pressure, high cholesterol and diabetes.
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