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Brand Name :
Domar
Synonyms :
pinazepam
Class :
Benzodiazepine
Brand Name :
Domar
Synonyms :
pinazepam
Class :
Benzodiazepine
Dosage forms and strengths Â
Oral capsuleÂ
10 mgÂ
5 mgÂ
2.5 mgÂ
Indicated for Anxiety disorders
The recommended dose is 5-20 mg/day orally
The recommended dose is 2.5-5 mg at sleep time
Not indicatedÂ
Refer adult dosingÂ
The potential for increased CNS depression risk or seriousness occurs when amisulpride is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when amitriptyline is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when amobarbital is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when amoxapine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when apomorphine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when aripiprazole is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when benperidol is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when benzocaine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when bromocriptine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when brompheniramine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when bupivacaine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when buspirone is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when butabarbital is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when carbamazepine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when cetirizine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when chlorpheniramine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when cisapride is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when clonazepam is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when cyclizine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when dantrolene is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when desflurane is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when desipramine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when dexbrompheniramine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when dextromethorphan is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when diazepam is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when dihydroergotamine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when donepezil is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when doxepin is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when ergometrine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when ergotamine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when estazolam is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when fenfluramine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when flibanserin is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when flunarizine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when gabapentin is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when haloperidol is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when halothane is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when imipramine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when ketamine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when ketazolam is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when lamotrigine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when levobupivacaine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when levocetirizine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when lidocaine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when lisuride is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when lorazepam is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when loxapine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when melatonin is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when mephenytoin is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when mepivacaine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when methysergide is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when acetazolamide is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when acetophenazine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when agomelatine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when alimemazine is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when almotriptan is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when alosetron is used together with pinazepam
The potential for increased CNS depression risk or seriousness occurs when alprazolam is used together with pinazepam
Actions and Spectrum:Â
Action:Â
Anxiolytic (Anti-Anxiety) Effects: pinazepam acts on the brain’s gamma-aminobutyric acid (GABA) neurotransmitter system. It enhances the inhibitory effects of GABA, leading to a reduction in neuronal excitability. This results in a calming effect on the central nervous system and a decrease in feelings of anxiety and stress.Â
Sedative and Hypnotic Effects: Due to its ability to increase GABAergic activity, pinazepam has sedative and hypnotic effects. It can help induce relaxation and sleepiness, making it useful for individuals with insomnia or those who have trouble falling asleep.Â
Spectrum:Â
The spectrum of effects of pinazepam can vary depending on the dosage, individual sensitivity, and specific medical condition being treated It is crucial to emphasize that, like other benzodiazepines, the use of pinazepam for prolonged periods or in excessive amounts can result in the development of dependence and the emergence of withdrawal symptoms. Therefore, it’s typically prescribed for short-term use to manage acute anxiety symptoms or other related conditions.Â
Frequency not defined  Â
Psychiatric disorders: ConfusionÂ
Nervous system disorders: drowsiness, dizziness, AtaxiaÂ
Hepatobiliary disorders: liver damage, RarelyÂ
Cardiac disorders: tachycardia, PalpitationsÂ
Black Box Warning:Â Â
None Â
Contraindication/Caution:Â Â
Hypersensitivity: Individuals who have a known hypersensitivity or allergy to pinazepam or other benzodiazepines should avoid using the medication.Â
Respiratory Issues: pinazepam can cause respiratory depression, especially when taken in larger doses or combined with other central nervous system depressants like alcohol. It should be used with caution in individuals with respiratory disorders.Â
Severe Liver Impairment: Benzodiazepines are metabolized in the liver, and individuals with severe liver impairment might have difficulty metabolizing these drugs properly, leading to an increased risk of side effects.Â
Pregnancy and Breastfeeding: Benzodiazepines like pinazepam can potentially harm the developing fetus or be passed on to infants through breast milk. They are generally avoided during pregnancy and breastfeeding unless the potential benefits outweigh the risks and safer alternatives are not available.Â
Elderly Individuals: Older adults may be more sensitive to the effects of pinazepam and might experience excessive sedation, dizziness, or confusion.Â
History of Substance Abuse: Individuals with a history of substance abuse, especially with alcohol or other central nervous system depressants, One should exercise careful consideration when using pinazepam, as there exists a potential for addiction or dependency.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology:Â Â
pinazepam is a benzodiazepine derivative that possesses anxiolytic (anti-anxiety), sedative, hypnotic (sleep-inducing), and muscle relaxant properties.Â
Pharmacodynamics:Â Â
pinazepam, like other benzodiazepines, binds to specific receptors on GABA receptors in the brain. This binding increases the inhibitory effects of GABA, leading to decreased neuronal excitability and an overall calming effect on the central nervous system.  Â
Pharmacokinetics:Â
AbsorptionÂ
pinazepam is orally administered and is well absorbed from the gastrointestinal tract. Â
DistributionÂ
The drug and its active metabolites are distributed throughout the body, including the central nervous system (CNS), where they exert their effects. pinazepam crosses the blood-brain barrier due to its lipophilic nature.Â
MetabolismÂ
pinazepam is extensively metabolized in the liver primarily by enzymatic processes involving cytochrome P450 (CYP) enzymes, particularly CYP3A4 and CYP2C19. The major metabolites formed are the 3-hydroxy and 4-hydroxy derivatives of pinazepam. These metabolites are pharmacologically active and contribute to the overall effects of the drugÂ
Excretion and EliminationÂ
The metabolites of pinazepam are mainly excreted in the urine. The duration of pinazepam’s elimination half-life and metabolites may differ based on individualized aspects like age, liver performance, and simultaneous utilization of other drugs.Â
Administration: Â
The administration is by oral route.Â
Patient information leafletÂ
Generic Name: pinazepamÂ
Why do we use pinazepam? Â
Anxiety Disorders: pinazepam, like other benzodiazepines, can be prescribed for the short-term management of various anxiety disorders.It can help alleviate symptoms of excessive worry, nervousness, and tension.Â
Insomnia: Due to its sedative properties, pinazepam might have been prescribed to individuals struggling with insomnia or other sleep disturbances. Â
Muscle Relaxation: pinazepam may also have been used as a muscle relaxant in certain medical situations. It can help alleviate muscle spasms and tension.Â
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